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Cixutumumab Cixutumumab (IMC-A12) is a human anti- IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IMC-A12; NSC742460. CAS No. 947687-12-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99189. MedChemExpress MCE
Cixutumumab Cixutumumab is a humanized anti-IGF-1R monoclonal antibody for the treatment of solid tumors. Cixutumumab selectively binds to membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Synonyms: IMC-A12; NSC742460. CAS No. 947687-12-9. BOC Sciences 11

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