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| Product | Description | |
|---|---|---|
| 6-(3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy-β-D-galactopyranosyloxy)-N-((2R,3R)-1-O-(4,4'-dimethoxytrityl)-1,3-dihydroxybutan-2-yl)hexanamide | It is a DMT-protected GalNAc (N-acetylgalactosamine) derivative featuring a 6-carbon linker and a threoninol scaffold. It is designed as a monomeric building block for the synthesis of multivalent GalNAc clusters. The structure includes a tri-O-acetylated GalNAc moiety attached to a threoninol backbone via a hexyl linker, with the primary hydroxyl group protected by a dimethoxytrityl (DMT) group. This design allows for efficient incorporation into oligonucleotides during solid-phase synthesis while maintaining stability and reactivity. The acetyl groups on GalNAc can be selectively removed to reveal the active sugar for receptor binding, making it a versatile intermediate for constructing targeted siRNA or antisense oligonucleotide conjugates. Synonyms: N-[(1R,2R)-1-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-hydroxypropyl]-6-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexanamide. CAS No. 2241043-51-4. Molecular formula: C45H58N2O14. Mole weight: 850.95. |  |
| 6-(3,4,6-Tri-O-acetyl-2-acetamido-2-deoxy-β-D-galactopyranosyloxy)-N-((2R,3R)-1-O-(4,4'-dimethoxytrityl)-3-O-(N,N-diisopropylamino-(2-cyanoethyloxy)-phosphonamidic)-1,3-dihydroxybutan-2-yl)hexanamide | It is a GalNAc (N-acetylgalactosamine) monomer phosphoramidite designed for the solid-phase synthesis of oligonucleotide conjugates. It features a GalNAc moiety attached to a threoninol scaffold via a hexyl linker, with the primary hydroxyl group protected by a dimethoxytrityl (DMT) group. The presence of a phosphoramidite group at the terminal end enables efficient incorporation into oligonucleotides during automated synthesis. This structure is designed to facilitate the creation of multivalent GalNAc clusters on oligonucleotides, enhancing their targeting efficiency to hepatocytes via the asialoglycoprotein receptor (ASGPR). It is a phosphoramidite for developing targeted nucleic acid therapeutics. CAS No. 2241043-52-5. Molecular formula: C54H75N4O15P. Mole weight: 1051.17. | |
| aconitate hydratase | Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds. Group: Enzymes. Synonyms: cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase. Enzyme Commission Number: EC 4.2.1.3. CAS No. 9024-25-3. Aconitase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5020; aconitate hydratase; EC 4.2.1.3; 9024-25-3; cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase. Cat No: EXWM-5020. |  |
| BCzPh | BCzPh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-Diphenyl-9H ,9'H-3,3'-bicarbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 57102-62-2. Molecular formula: C36H24N2. Mole weight: 484.59 g/mol. Product ID: ACM57102622. Alfa Chemistry ISO 9001:2015 Certified. Categories: BCG of Phoenix Cluster. |  |
| GalNAc-Cluster-COOH | GalNAc-Cluster-COOH is a functionalized ligand designed for targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). It features a trivalent GalNAc (N-acetylgalactosamine) cluster linked to a PEG spacer and terminated with a carboxylic acid group, which facilitates conjugation to other molecules. This compound is widely used in the development of lysosome-targeting chimeras (LYTACs) and for delivering nucleic acids or protein complexes to liver cells in a cell-specific manner. Its structure and valency enhance binding affinity to ASGPR, enabling efficient internalization and delivery of therapeutic agents. Synonyms: N2,N6-Bis[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysyl-N6-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysine; (17S,20S)-1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-20-(1-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-11-oxo-3,6,9-trioxa-12-azahexadecan-16-yl)-17-(2-(2-(2-(2-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)acetamido)-11,18-dioxo-3,6,9-trioxa-12,19-diazahenicosan-21-oic acid. Grade: >98%. CAS No. 1332358-22-1. Molecular formula: C60H107N7O33. Mole weight: 1454.52. | |
| GalNAc-L96 Linker-Acid | GalNAc-L96 Linker-Acid is a specialized chemical compound designed for the synthesis of targeted nucleic acid delivery systems. It features a triantennary GalNAc (N-acetylgalactosamine) cluster linked to a longer PEG-based linker, terminating with a carboxylic acid group. This structure allows for efficient conjugation to oligonucleotides, such as siRNA, enabling targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). The compound is widely used in the development of RNA interference (RNAi) therapies, particularly for liver-related diseases. This linker is a key intermediate in the synthesis of GalNAc-siRNA conjugates, which have demonstrated superior stability and gene silencing efficiency compared to traditional lipid nanoparticle delivery systems. Synonyms: 12,19,25-Trioxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacosanoic acid; 1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-16,16-bis((3-((3-(5-(((2R,3R,4. Grade: ≥97%. CAS No. 1426159-34-3. Molecular formula: C91H148N10O39. Mole weight: 2006.22. | |
| GalNAc-L96 Linker-Azide | GalNAc-L96 Linker-Azide is a specialized chemical compound designed for the development of targeted nucleic acid delivery systems. It features a triantennary GalNAc (N-acetylgalactosamine) cluster linked to a PEG-based linker, terminating with an azide group. This structure allows for efficient conjugation to oligonucleotides or other therapeutic agents through click chemistry, enabling targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). GalNAc-L96 Linker-Azide is particularly useful in the synthesis of GalNAc-siRNA conjugates, which have demonstrated high efficiency in liver-targeted gene silencing. The azide group provides a convenient handle for conjugation, making it suitable for the development of advanced drug delivery systems, especially for RNA interference (RNAi) therapies. Grade: ≥97%. CAS No. 2135330-72-0. Molecular formula: C90H147N13O37. Mole weight: 2003.22. | |
| MDK-7553 | MDK-7553, also known as CD38 inhibitor 78c and Compound-78c, is a potent CD38 inhibitor. MDK-7553 has CAS#1700637-55-3, which was reported in J Med Chem. 2015 Apr 23;58(8):3548-71. For the convenience of scientific communication, we name it as MDK-7553. The last four digits of CAS# were used for its name. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CD38 inhibitor 78c; Compound-78c; CD38i_78c; 78c; Cluster of Differentiation 38 Inhibitor; MDK-7553; MDK 7553; MDK7553; CD38-IN-78c; CD38 IN-78c; CD38IN-78c; CD38 inhibitor 78c. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1700637-55-3. Molecular formula: C22H27N3O3S. Mole weight: 413.54. Purity: >98%. IUPACName: 4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one. Canonical SMILES: O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1. Product ID: ACM1700637553. Alfa Chemistry ISO 9001:2015 Certified. | |
| Nystatin | Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin is a cholesterol-sequestering agent, partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MORONAL;MYCOSTATIN;MYCOSTATIN(R);NYSTATIN, STREPTOMYCES NOURSEI;NYSFUNGIN;NYSTATIN;biofanal;candio-hermal. Product Category: Inhibitors. Appearance: suspension. CAS No. 1400-61-9. Molecular formula: C47H75NO17. Mole weight: 926.09. Purity: 0.9829. Canonical SMILES: C[C@@H]1OC(C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@@](O)(O[C@H]2C[C@H](/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]([C@@H](O)[C@H]1C)C)O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C[C@H](O)[C@H]2C(O)=O)=O.[Nystatin A1]. Product ID: ACM1400619. Alfa Chemistry ISO 9001:2015 Certified. | |
| Tri-b-GalNAc-b-alanine-PEG3-biotin | Tri-b-GalNAc-b-alanine-PEG3-biotin is a functionalized ligand designed for targeting the asialoglycoprotein receptor (ASGPR) on hepatocytes. It consists of a trivalent β-GalNAc cluster linked to a biotin tag via a β-alanine-PEG3 spacer. This structure enables efficient binding to ASGPR, facilitating the uptake of biotinylated molecules by liver cells. It is widely used in applications such as lysosomal targeting, hepatocyte studies, and targeted drug delivery. Synonyms: Tri-GalNAc biotin; Triantennary GalNAc-β-Alanine-PEG3-Biotin; Tri-GalNAc-β-Ala-PEG3-Biotin; (β-GalNAc)3-sp-β-Ala-PEG3-Biotin; Tris-β-GalNAc-β-Ala-PEG3-biotin; Triantennary β-D-GalNAc-β-Alanine-PEG3-Biotin; Tris-GalNAc-β-Ala-PEG3-Biotin; Tris-GalNAc-β-Ala-PEG3-Biotin; (β-D-GalNAc-sp)3-NHC(O)-(CH2)2-NHC(O)-PEG3-NH-Biotin. Grade: >95% by HPLC. CAS No. 3062597-46-7. Molecular formula: C83H146N14O34S. Mole weight: 1916.19. | |
| Tri-b-GalNAc-gly-biotin | Tri-b-GalNAc-gly-biotin is a functionalized ligand designed for targeted drug delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). It features a trivalent GalNAc cluster linked to biotin through a glycine spacer, enabling efficient uptake by liver cells through ASGPR-mediated endocytosis. In drug delivery applications, Tri-b-GalNAc-gly-biotin can be used to conjugate therapeutic agents, such as siRNA or proteins, to facilitate their specific delivery to the liver. The biotin moiety can also bind to streptavidin or neutravidin, which can be further functionalized to carry drug payloads. This approach enhances the therapeutic efficacy of the drug while reducing off-target effects, making it a valuable tool for liver-targeted therapies. Synonyms: Tris-β-GalNAc-Gly-biotin; Biotin-Gly-tris-beta-GalNAc; Trebler GalNAc Biotin; Tri-GalNAc-β-Gly-Biotin; Triantennary GalNAc beta glycine biotin; Biotin-Gly-tris-beta-GalNAc; Biotin-Gly-tris-β-GalNAc. Grade: >90% by HPLC. Molecular formula: C73H127N13O30S. Mole weight: 1698.93. | |
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