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Coelenterazine is a luciferin, a light-emitting biomolecule that serves as a substrate for luciferases or as a constituent of photoproteins, including aequorin.1 The oxidation of coelenterazine to coelenteramide is accompanied by emission of blue light (emission maximum, 460-470 nm). Luciferase-mediated oxidation of coelenterazine or a derivative is used as an energy donor, typically to a form of green or yellow fluorescent protein, in bioluminescent resonance energy transfer studies.2,3 Alternatively, the calcium-mediated release of coelenterazine from aequorin, followed by non-enzymatic oxidation of this compound, results in bioluminescence. As light emission depends on both calcium and cellular redox status, this reaction is used to non-fluorescently detect changes in calcium level and redox status.4,5. Group: Biochemicals. Alternative Names: 3,2-Dihydro-2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3-one; CLZN; Preluciferin; Luciferin; 6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-8-(phenylmethyl)-imidazo[1,2-a]pyrazin-3(7H)-one. Grades: Highly Purified. CAS No. 55779-48-1. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 423.46. US Biological Life Sciences.
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Coelenterazine
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 55779-48-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18743.
Coelenterazine 400a
Coelenterazine 400 a is a chromophore that produces the chemiluminescence displayed by the Aequorin protein in the presence of Ca2+. Group: Biochemicals. Alternative Names: 6-Phenyl-2, 8-bis (phenylmethyl) imidazo[1, 2-a]pyrazin-3 (7H) -one; Bisdeoxycoelenterazine ; Coelenterazine HH; DeepBlueC; Dideoxycoelenterazine; BlueSyn C; 2,8-Dibenzyl-6-phenyl-imidazo[1,2a]pyrazin-3-(7H)-one. Grades: Highly Purified. CAS No. 70217-82-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C??H??N?O, Molecular Weight: 391.46. US Biological Life Sciences.
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca 2+ , thus providing a valuable tool for measuring small changes in Ca 2+ concentrations [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Deoxycoelenterazine; CLZN-h. CAS No. 50909-86-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1024.
Coelenterazine h
Coelenterazine h. Group: Biochemicals. Alternative Names: 2-Deoxycoelenterazine; 2, 8-dibenzyl-6- (4-hydroxyphenyl) imidazo[1, 2-a]pyrazin-3 (7H) -one. Grades: Highly Purified. CAS No. 50909-86-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 20mg. Molecular Formula: C26H21N3O2. US Biological Life Sciences.
solid. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 55779-48-1. Pack Sizes: 50?G. Mole weight: 423.46. Catalog: AP55779481. Assay: ?95% (TLC).
Coelenterazine v
Coelenterazine v. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 20mg. US Biological Life Sciences.
Worldwide
Coelenteramine 400a
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Coelenterazine 400a; Bisdeoxycoelenterazine. CAS No. 70217-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-118462.
Oplophorus-luciferin 2-monooxygenase
The luciferase from the deep sea shrimp Oplophorus gracilirostris is a complex composed of more than one protein. The enzyme's specificity is quite broad, with both coelenterazine and bisdeoxycoelenterazine being good substrates. Group: Enzymes. Synonyms: Oplophorus luciferase. Enzyme Commission Number: EC 1.13.12.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0606; Oplophorus-luciferin 2-monooxygenase; EC 1.13.12.13; Oplophorus luciferase. Cat No: EXWM-0606.
pyCTZ
pyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, and is an ATP-independent pyridyl substrate of LumiLuc luciferase. pyCTZ generates strong blue bioluminescence in the presence of luciferases. pyCTZ can be used for aequorin-based calcium sensing [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Pyridyl CTZ. CAS No. 2125486-34-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135367.
QTZ
QTZ is a bioluminescence agent for in vivo imaging. QTZ has red-shifted emission and yields very little background. QTZ is a coelenterazine analog with the 4-quinolinyl substitution at the C8 position of the imidazopyrazinone core [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2883232-39-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-47176.
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