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| Product | Description | |
|---|---|---|
| Covalent Inhibitor Library | A unique collection of 941 covalent Inhibitors and other molecules with common warheads like chloroacetyl?2-Chloropropionyl?Acryloyl?sulfonyl fluoride, alkyne?acrylamide, ketocarbonyl?disulfide bond, etc. - Structurally diverse with some covalent inhibitors approved by the FDA- Detailed compound information with structure, target, IC50, and biological activity description- NMR and HPLC/LCMS validated to ensure high purity. Uses: Scientific use. Product Category: L9410. Categories: Covalent Inhibitor Libraries. |  |
| Covalent Natural Product Library | Detialed biological information and pharmacological information of the products, providing theoretical direction and research basis for screening. - Clear source: a selection of known active natural products from animals, plants and microorganisms; specific to plant species, and labeled with accurate English and Latin names that facilitates later verification in your research. - Comprehensive information: Detailed descriptions from compound structure to solubility, from signaling pathways and targets to biological activity information. - Cost-effective: eliminates expensive natural products with poor drug-forming properties, allowing you to get more high-quality natural products at a lower cost. - Highly customizable with free combination according to natural product source, natural product category, research area, drug market status, etc. Uses: Scientific use. Product Category: L6150. Categories: Covalent Natural Product Libraries. | |
| Cysteine Covalent Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery and synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening. Uses: Scientific use. Product Category: L9411. Categories: Cysteine Covalent Libraries. | |
| Mini Electrophilic Heterocyclic Fragment Library | The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. Targeted covalent inhibitors and chemical probes have become part of drug discovery methods. Given the advantages of fragment-based drug discovery, screening electrophilic fragments has become a promising alternative to discover and verify new targets and generate viable chemical starting points, even for targets that are almost difficult to handle. In response to this situation, we designed a small library of heterocyclic electrophilic compounds. General technology for covalent fragment screening ?. Uses: Scientific use. Product Category: L7860. Categories: Mini Electrophilic Heterocyclic Fragment Libraries. | |
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