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| Product | Description | |
|---|---|---|
| Q203 | Q203, also known as IAP6, was active against the reference strain M. tuberculosis H37Rv at a minimum concentration required to inhibit the growth of 50% of organisms (MIC50) of 2.7 nM in culture broth medium and at a MIC50 of 0.28 nM inside macrophages. Synonyms: Q203; Q 203; Q-203; 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide; 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide. CAS No. 1334719-95-7. Molecular formula: C29H28ClF3N4O2. Mole weight: 557.01. |  |
| Streptomycin | Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis , is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Agrept; Agrimycin; Streptomycin A. CAS No. 57-92-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1906. |  |
| Telacebec | Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC 50 of 2.7 nM in culture broth medium. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Q203; IAP6. CAS No. 1334719-95-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101040. | |
| Telacebec free base | Telacebec, also known as Q-203, is an antituberculosis agent and a potent inhibitor of mycobacterium tuberculosis protein potentially for the treatment of tuberculosis. Telacebec targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound. In addition, Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Telacebec free base; Q-203 free base; Q 203; Q203. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1334719-95-7. Molecular formula: C29H28ClF3N4O2. Mole weight: 557.01. Purity: >98%. IUPACName: 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide. Canonical SMILES: O=C(C1=C(CC)N=C2C=CC(Cl)=CN21)NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3. Product ID: ACM1334719957. Alfa Chemistry ISO 9001:2015 Certified. |  |
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