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| Product | Description | |
|---|---|---|
| Cyclopamine | Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched. Group: Biochemicals. Alternative Names: (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-. Grades: Highly Purified. CAS No. 4449-51-8. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Cyclopamine | Cyclopamine is a Hedgehog ( Hh ) pathway antagonist with an IC 50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Deoxojervine. CAS No. 4449-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17024. |  |
| Cyclopamine (11-Deoxyjervine) | Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumor suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle. Group: Biochemicals. Alternative Names: 11-Deoxyjervine. Grades: Highly Purified. CAS No. 4449-51-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldi hydrocinnamoyl cyclopamine, Shh Signaling Antagonist II) | A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay; 50nM in p2Ptch-/-cells; 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Group: Biochemicals. Grades: Purified. CAS No. 306387-90-6. Pack Sizes: 100ug. Molecular Formula: C??H??N?O?, Primary Target: Hh signaling in Shh-light2 assay. US Biological Life Sciences. | Worldwide |
| Cyclopamine tartrate | Cyclopamine tartrate. Group: Biochemicals. Alternative Names: (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-1, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11, 11a, 11b-Octadecahydro-3', 6', 10, 11b-tetramethylspiro[9H-benzo[a]fluorene-9, 2'(3'H)-furo[3, 2-b]pyridin]-3-ol Tartrate. Grades: Highly Purified. CAS No. 1178510-81-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C29H44NO5. US Biological Life Sciences. | Worldwide |
| Cyclopamine tartrate | Heterocyclic Organic Compound. Alternative Names: (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-. CAS No. 1178510-81-0. Molecular formula: C29H44NO5. Mole weight: 486.66. Purity: 0.96. Catalog: ACM1178510810. |  |
| 3- hydroxy-N-aminoethyl-N-aminocaproyldi hydrocinnamoyl Cyclopamine | A precursor to KAAD cyclopamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 0.25mg. US Biological Life Sciences. | Worldwide |
| 3-Keto-N-aminoethyl-N-aminocaproyldi hydrocinnamoyl Cyclopamine (KAAD-Cyclopamine) | Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells. Group: Biochemicals. Alternative Names: KAAD-Cyclopamine. Grades: Highly Purified. CAS No. 306387-90-6. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Bodipy Cyclopamine | A fluorescent Cyclopamine derivative that retains potency in Shh signaling inhibition (IC??=150nm). Group: Biochemicals. Alternative Names: [5-[(3, 5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-N-[6-[[2-[(3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 2'R, 11aS, 11bR)-1, 2, 3, 3', 3'a, 4, 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11, 11a, 11b-octadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethylspiro[9H-benzo[a]fluorene-9, 2'(4'H)-furo[3, 2-b]pyridin]-4'-yl]ethyl]amino]-6-oxohexyl]-1H-pyrrole-2-propanamidato-κN1]difluoro-boron. Grades: Highly Purified. CAS No. 334658-24-1. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Cyanine-3 Cyclopamine, Potassium Salt (Cy-3-Cyclopamine, Potassium Salt) | A fluorescent deriviative of Cyclopamine, which demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1. Group: Biochemicals. Alternative Names: Cy-3-Cyclopamine, Potassium Salt. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Despiro-cyclopamine (Despiro-11-Deoxyjervine) | An analogue of Cyclopamine, a sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: Despiro-11-Deoxyjervine. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-(2-Aminoethyl) Cyclopamine | A deriviative of Cyclopamine, which demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| N- (5-Fluoresceinyl) -N- (2-cyclopamineethyl) thiourea (Fluoresceinyl Cyclopamine) | A fluorescent Cyclopamine derivative. Group: Biochemicals. Alternative Names: Fluoresceinyl Cyclopamine. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Hh Signaling Antagonist XII, MRT-83 (N- (2-Methyl-5- (3- (3, 4, 5-trimethoxybenzoyl) guanidino) phenyl) - (1, 1-biphenyl) -4-carboxamide) | A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50=15nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG- induced C3H10T1/2 cell differentiation (IC50=10nM in an alkaline phosphatase activity assay). Inhibits ShhN (3nM) and SAG (10nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~3 and 6nM, respectively). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| MRT 10 | MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells. Synonyms: MRT 10; MRT10; MRT-10; N-[[[3-Benzoylamino) phenyl]amino]thioxomethyl]-3, 4, 5-trimethoxybenzamide. Grades: ≥98%. CAS No. 330829-30-6. Molecular formula: C24H23N3O5S. Mole weight: 465.52. |  |
| MRT-83 | This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing greater potency than cyclopamine, another Smoothened antagonist. MRT-83 efficiently antagonizes Hh signaling in vivo. MRT-83 will be useful for manipulating Hh signaling and may help develop new treatment for Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83; MRT 83; MRT83; N-[5-[[imino[ (3, 4, 5-trimethoxybenzoyl) amino]methyl]amino]-2-methylphenyl]-[1, 1'-Biphenyl]-4-carboxamide; 1359944-60-7 (HCl salt). Grades: 98%. CAS No. 1263131-92-5. Molecular formula: C31H30N4O5. Mole weight: 538.59. | |
| MRT-83 hydrochloride | MRT-83 (hydrochloride) is the potent antagonist of Smoothened ( Smo ) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359944-60-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287A. | |
| MRT-83 hydrochloride | MRT-83 is a Smoothened (Smo) antagonist. It can block Hedgehog (Hh) signaling in various assays. MRT-83 can also inhibit Bodipy-cyclopamine binding to human and mouse Smo. MRT-83 can efficiently antagonize Hh signaling in vivo. MRT-83 may help develop new therapies for the treatment of Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83 hydrochloride; MRT 83 hydrochloride; MRT83 hydrochloride; N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;1263131-92-5 (free base). Grades: 98%. CAS No. 1359944-60-7. Molecular formula: C31H31ClN4O5. Mole weight: 575.06. | |
| SAG | SAG is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912545-86-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12848. | |
| SAG | SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); sag antagonizes cyclopamine action at the Smo receptor. Synonyms: SAG. Grades: 98%. CAS No. 912545-86-9. Molecular formula: C28H28ClN3OS. Mole weight: 490.06. | |
| SAG dihydrochloride | SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2702366-44-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-12848C. | |
| SAG Dihydrochloride (Water Soluble) (N-Methyl-N?- (3-pyridinylbenzyl) -N?- (3-chlorobenzo [b]thiophene-2-carbonyl) -1, 4-diaminocyclohexane. 2HCl) | Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 364590-63-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| SAG hydrochloride | SAG hydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2095432-58-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12848B. | |
| SAG (Standard) | SAG (Standard) is the analytical standard of SAG. SAG is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912545-86-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-12848R. | |
| SANT-2 | SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling and an antagonist of smoothened receptor activity (KD = 12 nM). SANT-2 exhibits smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki = 7.8 nM and 8.4 nM, respectively). Synonyms: SANT-2; SANT 2; SANT2; N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide. Grades: ≥98% by HPLC. CAS No. 329196-48-7. Molecular formula: C26H26ClN3O4. Mole weight: 479.96. | |
| Saridegib | Saridegib is an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity, one of smoothened (Smo) inhibitors. Synonyms: SARIDEGIB; IPI-926 Hydrochloride; Patidegib. CAS No. 1037210-93-7. Molecular formula: C29H48N2O3S. Mole weight: 504.77. | |
| Smoothened Agonist, SAG (N-Methyl-N- (3-pyridinylbenzyl) -N- (3-chlorobenzo [b]thiophene-2-carbonyl) -1, 4-diaminocyclohexane, SAG1.3 ) | A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (=59nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= ?3nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Group: Biochemicals. Grades: Highly Purified. CAS No. 364590-63-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Tomatidine Hydrochloride | Tomatidine is a steroidal alkaloid found in the skins of unripe tomatoes. Structurally, Tomatidine resembles cylopamine, but does not inhibit the Hedgehog (Hh) signaling pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Group: Biochemicals. Alternative Names: 3b-Hydroxy-5a-tomatidane Hydrochloride, 5a-Tomatidan-3b-ol hydrochloride; (3 β,5α,22 β,25S)-Spirosolan-3-ol Hydrochloride. Grades: Highly Purified. CAS No. 6192-62-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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