Deacetylase Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Acetylome - Deacetylase Microarray Quick inquiry Where to buy Suppliers range | Acetylome - Deacetylase Microarray. Uses: Enzyme Substrate Arrays. Product ID: PMA-H117. | |
Cancer Hydrolase KIAA1363 Inhibitor, JW480 (2-Isopropylphenyl-2- (2-naphthyl) ethylcarbamate, AADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor) Quick inquiry Where to buy Suppliers range | A membrane-permeable, highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50=12nM; PC3 lysate) and murine (IC50=20nM; brain membrane samples) origin, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice and effectively suppresses PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80mg/kg/day; o.g.). Also inhibits blood carboxylesterase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
HDAC Inhibitor XVII ((E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII) Quick inquiry Where to buy Suppliers range | A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0uM), HDAC2/4/6/10/11 (IC50 >20uM), or total HDAC activity in HeLa nuclear extract (IC50 >10uM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8uM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Primary Target IC50: 27nM. US Biological Life Sciences. | Worldwide |
Histone Deacetylase Inhibitor IV - CAS 537034-15-4 Quick inquiry Where to buy Suppliers range | The Histone Deacetylase Inhibitor IV, also referenced under CAS 537034-15-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 537034-15-4. Pack Sizes: 10MG. Mole weight: 325.40. Catalog: AP537034154. Assay: ≥97% (HPLC). | |
Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 Quick inquiry Where to buy Suppliers range | The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 1045792-66-2. Pack Sizes: 1MG. Mole weight: 446.50. Catalog: AP1045792662. Assay: ≥95% (HPLC). | |
NAD-dependent protein deacetylase sirtuin-2 (192-200) Quick inquiry Where to buy Suppliers range | NAD-dependent protein deacetylase sirtuin-2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-235. | |
NAD-dependent protein deacetylase sirtuin-2 (192-200) Quick inquiry Where to buy Suppliers range | NAD-dependent protein deacetylase sirtuin-2 (192-200) is amino acids 192 to 200 fragment of NAD-dependent protein deacetylase sirtuin-2. NAD-dependent protein deacetylase sirtuin-2 plays a major role in the control of cell cycle progression and genomic stability. Synonyms: Regulatory protein SIR2 homolog 2 (192-200); SIR2-like protein 2 (192-200). | |
Sodium Butyrate, 0.5M (Histone Deacetylase Inhibitor) Quick inquiry Where to buy Suppliers range | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
Sodium Butyrate, 1M (Histone Deacetylase Inhibitor) Quick inquiry Where to buy Suppliers range | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
Trichostatin A (TSA) (Histone Deacetylase Inhibitor)89/1/20 Quick inquiry Where to buy Suppliers range | Trichostatin A is an antifungal antibiotic that is a reversible, potent and specific inhibitor of mammalian histone deacetylase (HDAC) both in vivo and in vitro. Histone deacetylase inhibition causes chromatin relaxation and gene expression modulation. May induce apoptosis. TSA inhibits the eukaryotic cell cycle and induces morphological reversion of transformed cells. It blocks cell cycle progression at G1 phase in Hela Cells. TSA causes accumulation of highly acetylated histones in vivo, while inhibiting the activity of partially purified histone deacetylase in vitro. Group: Biochemicals. Alternative Names: 4,6-Dimethyl-7-[p-dimethylaminophenyl]- 7-oxohepta-2, 4-dienohydroxamic acid). Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
1-(2,4-Dichlorobenzoyl)-1H-benzotriazole Quick inquiry Where to buy Suppliers range | Histone deacetylase (HDAC) inhibitors are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710). Group: Biochemicals. Grades: Highly Purified. CAS No. 200626-61-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H7Cl2N3O, Molecular Weight: 292.12. US Biological Life Sciences. | Worldwide |
1-(2-Aminothiazol-4-yl)ethanone Quick inquiry Where to buy Suppliers range | 1-(2-Aminothiazol-4-yl)ethanone is a versatile reactant, used as intermediate in preparation of multicyclic sulfonamide compounds as histone deacetylase inhibitors useful in treatment and prevention of diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 101258-16-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C5H6N2OS, Molecular Weight: 142.18. US Biological Life Sciences. | Worldwide |
1- (4- (1, 3, 4-Oxadiazol-2-yl) phenyl) -3- ( (5- (2, 2, 2-trifluoroacetyl) thiophene-2-carbonyl) oxy) guanidine Quick inquiry Where to buy Suppliers range | 1- (4- (1, 3, 4-Oxadiazol-2-yl) phenyl) -3- ( (5- (2, 2, 2-trifluoroacetyl) thiophene-2-carbonyl) oxy) guanidine is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C16H10F3N5O4S. US Biological Life Sciences. | Worldwide |
1-(4-Hydroxyphenyl)-2-chloroethanol Quick inquiry Where to buy Suppliers range | 1-(4-Hydroxyphenyl)-2-chloroethanol is synthesized from 2-Chloro-1-(4-hydroxy-phenyl)-ethanone. 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4973-17-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C8H9ClO2, Molecular Weight: 172.61. US Biological Life Sciences. | Worldwide |
1-Alaninechlamydocin Quick inquiry Where to buy Suppliers range | It is a cyclic tetrapeptide antibiotic containing a single β-amino acid, which was isolated from diheterospora chlamydosporia in 1992. It is less widely characterised than the related chlamydocin. It exhibits potent antitumor activity and acts by inhibiting histone deacetylase. Synonyms: Cyclo[L-alanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxooxiraneoctanoyl]; (S)-Cyclo(L-alanyl-L-phenylalanyl-D-prolyl-η-oxo-L-α-aminooxiraneoctanoyl). Grades: >95% by HPLC. CAS No. 141446-96-0. Molecular formula: C27H36N4O6. Mole weight: 512.61. | |
1-?Aminocycloheptane car?boxylic Acid Quick inquiry Where to buy Suppliers range | 1-?Aminocycloheptane car?boxylic Acid is used in the synthesis of chlamydocin-hydroxamic acid analogs with histone deacetylase inhibitory activities. It is also used to prepare imidazobioxazolium triflates as precursors for sterically hindered and electron-donating N-heterocyclic carbene ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 6949-77-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H15NO2, Molecular Weight: 157.21. US Biological Life Sciences. | Worldwide |
1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride Quick inquiry Where to buy Suppliers range | 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride is used in the image-guided synthesis of potent blood-brain barrier permeable histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1432679-85-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H18N2; HCi, Molecular Weight: 154.252364599999. US Biological Life Sciences. | Worldwide |
1-(Pyrazin-2-yl)-2-trifluoroacetyl Hydrazine Quick inquiry Where to buy Suppliers range | 1-(Pyrazin-2-yl)-2-trifluoroacetyl Hydrazine can be used as reactant/reagent in synthetic preparation of tricyclic hydroxamic acids as inhibitors of histone deacetylase. Group: Biochemicals. Grades: Highly Purified. CAS No. 837430-15-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H5F3N4O, Molecular Weight: 206.13. US Biological Life Sciences. | Worldwide |
2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid Quick inquiry Where to buy Suppliers range | 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid functions as a co-drugs, and also acts as a reagent for the preparation of hydroxamate-based histone deacetylase inhibitors for enhancing activity of antifungal agents which inhibit a step in the ergosterol synthesis pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 933682-63-4. Pack Sizes: 1g, 10g. Molecular Formula: C6H13NO2S, Molecular Weight: 163.24. US Biological Life Sciences. | Worldwide |
2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetamidoxime Quick inquiry Where to buy Suppliers range | 2-[4- (1, 3, 4-Oxadiazole-2-yl) phenoxy]acetamidoxime is a reagent that is used to synthesize fluoroacetylthiophene oxadiazoles as class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 258521-20-9. Pack Sizes: 100mg, 1g. Molecular Formula: C10H10N4O3. US Biological Life Sciences. | Worldwide |
2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetonitrile Quick inquiry Where to buy Suppliers range | 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetonitrile is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 871218-36-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H7N3O2. US Biological Life Sciences. | Worldwide |
2,4,6-Tribromobenzyl Bromide Quick inquiry Where to buy Suppliers range | 2,4,6-Tribromobenzyl Bromide acts as a reagent for the design, synthesis and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry. Group: Biochemicals. Grades: Highly Purified. CAS No. 54459-64-2. Pack Sizes: 10g, 25g. Molecular Formula: C7H4Br4, Molecular Weight: 407.72. US Biological Life Sciences. | Worldwide |
[2-(4-Fluorophenyl)thiazol-4-yl]methanol Quick inquiry Where to buy Suppliers range | [2-(4-Fluorophenyl)thiazol-4-yl]methanol is an intermediate used in preparation of azole compounds as histone deacetylase (HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 885280-13-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H8FNOS, Molecular Weight: 209.24. US Biological Life Sciences. | Worldwide |
2- [ (4-Nitrophenyl) methylene] hydrazinecarboxamide Quick inquiry Where to buy Suppliers range | 2- [ (4-Nitrophenyl) methylene] hydrazinecarboxamide can be used to prepare benzimidazole derivatives. It is also a useful compound for developing histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 5315-87-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8N4O3, Molecular Weight: 208.17. US Biological Life Sciences. | Worldwide |
2-Acetamido-2-deoxy-b-D-glucopyranosyl serine Quick inquiry Where to buy Suppliers range | 2-Acetamido-2-deoxy-b-D-glucopyranosyl serine, an essential compound in the biomedical sector, plays a crucial role in the production of different glycopeptide antibiotics. Moreover, it also demonstrates its therapeutic potentialities by suppressing the activity of N-deacetylases in cells, which could be applicable in various diseases such as cancer. Given the multifaceted implications of this compound, it remains a topic of interest in the scientific community. | |
2-?Amino-?N-?(1-?phenyl-?ethyl)?-?benzamide Quick inquiry Where to buy Suppliers range | 2-?Amino-?N-?(1-?phenyl-?ethyl)?-?benzamide is a reagent used in the synthesis of potent inhibitors of class III histone/protein deacetylases. As well, used to prepare agents promoting anticonvulsant activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 85592-80-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C15H16N2O. US Biological Life Sciences. | Worldwide |
2-Chloro-1-(4-hydroxy-phenyl)-ethanone Quick inquiry Where to buy Suppliers range | 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 6305-04-0. Pack Sizes: 500mg, 5g. Molecular Formula: C8H7ClO2, Molecular Weight: 170.59. US Biological Life Sciences. | Worldwide |
2-Ethynylbiphenyl-13C6 Quick inquiry Where to buy Suppliers range | 2-Ethynylbiphenyl-13C6 is a reactant used in the preparation of labelled histone deacetylase (HDAC) inhibitors and EGFR tyrosine inhibitors. Group: Biochemicals. Alternative Names: 1-Ethynyl-2-phenylbenzene13C6; 2-Biphenylylacetylene 13C6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester acts as a reagent for the design, synthesis and biological evaluation of first-in-class dual acting histone deacetylase (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for treatment of Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 20417-61-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H10O3, Molecular Weight: 142.15. US Biological Life Sciences. | Worldwide |
2-Hexyl-4-pentynoic acid Quick inquiry Where to buy Suppliers range | 2-hexyl-4-pentynoic acid is a derivative of valproic acid, an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). Synonyms: 2-(prop-2-yn-1-yl)octanoic acid. Grades: ≥95%. CAS No. 96017-59-3. Molecular formula: C11H18O2. Mole weight: 182.3. | |
2-Methyl-5-nitrobenzenesulfonamide Quick inquiry Where to buy Suppliers range | 2-Methyl-5-nitrobenzenesulfonamide (CAS# 6269-91-6) is a chemical reagent in the synthesis of good inhibitors of cancer-related carbonic anhydrase. Also used in the synthesis of novel deacetylase inhibitors used in anti-tumor therapy. Synonyms: 2-methyl-5-nitrobenzenesulfonamide; 2-methyl-5-nitrobenzenesulfonamide. Grades: 98 %. CAS No. 6269-91-6. Molecular formula: C7H8N2O4S. Mole weight: 216.21. | |
2-Methyl-5-nitro Benzene sulfonamide Quick inquiry Where to buy Suppliers range | 2-Methyl-5-nitro Benzene sulfonamide is a chemical reagent in the synthesis of good inhibitors of cancer-related carbonic anhydrase. Also used in the synthesis of novel deacetylase inhibitors used in anti-tumor therapy. Group: Biochemicals. Grades: Highly Purified. CAS No. 6269-91-6. Pack Sizes: 1g, 5g. Molecular Formula: C7H8N2O4S, Molecular Weight: 216.21. US Biological Life Sciences. | Worldwide |
2-?Nitrophenyl Isocyanate Quick inquiry Where to buy Suppliers range | 2-?Nitrophenyl Isocyanate is a reagent used in the synthesis of histone deacetylase class III inhibitors which exhibit antiproliferative activity against cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 3320-86-3. Pack Sizes: 250mg, 1g. Molecular Formula: C7H4N2O3, Molecular Weight: 164.12. US Biological Life Sciences. | Worldwide |
2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride Quick inquiry Where to buy Suppliers range | 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride is a reactant used in the synthesis of pan-histone deacetylase (pan-HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 66657-42-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H8ClNO3S, Molecular Weight: 245.68. US Biological Life Sciences. | Worldwide |
(2-Thienylthio) acetonitrile Quick inquiry Where to buy Suppliers range | (2-Thienylthio) acetonitrile is an intermediate in the synthesis of possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 26031-45-8. Pack Sizes: 1g, 5g. Molecular Formula: C6H5NS2. US Biological Life Sciences. | Worldwide |
3-[ (2-Thienylsulfonyl) methyl]-5-[5-trifluoroacetyl-thien-2-yl]-1, 2, 4-oxadiazole Quick inquiry Where to buy Suppliers range | 3-[ (2-Thienylsulfonyl) methyl]-5-[5-trifluoroacetyl-thien-2-yl]-1, 2, 4-oxadiazole is a possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 946499-88-3. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C13H7F3N2O4S3. US Biological Life Sciences. | Worldwide |
3-[4-(1,3,4-Oxadiazol-2-yl)phenoxymethyl]-5-[5-trifluoroacetyl-thien-2-yl]-1,2,4-oxadiazole Quick inquiry Where to buy Suppliers range | 3-[4-(1,3,4-Oxadiazol-2-yl)phenoxymethyl]-5-[5-trifluoroacetyl-thien-2-yl]-1,2,4-oxadiazole is a possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 946500-06-7. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C17H9F3N4O4S. US Biological Life Sciences. | Worldwide |
3-? ( (4-?Methylpiperazin-?1-?yl) ?methyl) ?benzonitrile Quick inquiry Where to buy Suppliers range | 3-? ( (4-?Methylpiperazin-?1-?yl) ?methyl) ?benzonitrile is involved in the preparation of N- hydroxyphenyl acryl amide s and N-Hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 859850-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C13H17N3, Molecular Weight: 215.29. US Biological Life Sciences. | Worldwide |
3-Bromo-4- (methoxymethoxy) benzaldehyde Quick inquiry Where to buy Suppliers range | 3-Bromo-4- (methoxymethoxy) benzaldehyde is an intermediate in synthesizing CARM1-IN-1 Hydrochloride (C183610), a mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 162269-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H9BrO3. US Biological Life Sciences. | Worldwide |
3-Pyridinemethanol Quick inquiry Where to buy Suppliers range | 3-Pyridinemethanol, an aromatic alcohol compound, is a widely used in the synthesis of some inhibitors like Chk1 and histone deacetylase inhibitors. Uses: 3-pyridinemethanol is a widely used in the synthesis of some inhibitors like chk1 and histone deacetylase inhibitors. Synonyms: pyridin-3-ylmethanol. Grades: 95 %. CAS No. 100-55-0. Molecular formula: C6H7NO. Mole weight: 109.13. | |
4,5-Diaminopyrimidine Quick inquiry Where to buy Suppliers range | 4,5-Diaminopyrimidine is an intermediate in the synthesis of Nisin, a compound that was first introduced as a good preservative and was later on discovered to have antibacterial activity against gram positive bacteria. 4,5-Diaminopyrimidine is also used as a reagent to synthesize uracil-based 2-aminoanilide derivatives, compounds that act as histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 13754-19-3. Pack Sizes: 1g, 5g. Molecular Formula: C4H6N4, Molecular Weight: 110.12. US Biological Life Sciences. | Worldwide |
4'-Bromo-resveratrol Quick inquiry Where to buy Suppliers range | 4'-Bromo-resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3). Synonyms: 5-[(E)-2-(4-bromophenyl)vinyl]benzene-1,3-diol. Grades: ≥98%. CAS No. 1224713-90-9. Molecular formula: C14H11BrO2. Mole weight: 291.1. | |
4-Ethyl-2,3-dioxopiperazine-1-carbonyl Chloride Quick inquiry Where to buy Suppliers range | 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride is used as a reagent in the synthesis of amino(thienyl)benzamide derivatives which are used as histone deacetylase inhibitors and have antitumor activity. 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride is also a reagent in the synthesis of Cefbuperazone ; a second-generation cephalosporin antibiotic. Synonyms: 4-ethyl-2,3-dioxo-1-piperazinecarbonyl chloride; 4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride. Grades: > 95 %. CAS No. 59703-00-3. Molecular formula: C7H9ClN2O3. Mole weight: 204.61. | |
4-Iodo-SAHA Quick inquiry Where to buy Suppliers range | 4-Iodo-SAHA is a hydrophobic derivative of the class I and class II histone deacetylase (HDAC) inhibitor SAHA. Synonyms: N1-hydroxy-N8-(4-iodophenyl)octanediamide. Grades: ≥98%. CAS No. 1219807-87-0. Molecular formula: C14H19IN2O3. Mole weight: 390.2. | |
4SC-202 Quick inquiry Where to buy Suppliers range | 4SC-202 is a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes, with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. 4SC-202 also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. Synonyms: 4SC202; 4SC-202; 4SC 202; domatinostat; (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide. CAS No. 910462-43-0. Molecular formula: C23H21N5O3S. Mole weight: 447.51. | |
4SC-202 Tosylate Quick inquiry Where to buy Suppliers range | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711. | |
6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | 6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors. Group: Biochemicals. Alternative Names: 6-Bromo-1-benzothiophene-2-carboxylic Acid Methyl Ester; 6-Bromobenzo[b]thiophene-2-carboxylic Acid Methyl Ester; Methyl 6-bromo-1-benzothiophene-2-carboxylate; Methyl 6-Bromobenzo[b]thiophene-2-carboxylate. Grades: Highly Purified. CAS No. 360576-01-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
Abexinostat Quick inquiry Where to buy Suppliers range | Abexinostat, also known as PCI-24781 or CRA-024781, is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Synonyms: CRA-024781; CRA 024781; CRA024781; PCI-24781; PCI24781; PCI 24781. Grades: 98%. CAS No. 783355-60-2. Molecular formula: C21H23N3O5. Mole weight: 397.431. | |
Ac-Arg-Gly-Lys-AMC Quick inquiry Where to buy Suppliers range | Ac-Arg-Gly-Lys-AMC is a control for the two step histone deacetylase assay with Ac-Arg-Gly-Lys(Ac)-AMC. It corresponds to the product of the deacetylase reaction, which is subsequently cleaved by trypsin. Synonyms: Ac-RGK-AMC; N2-Acetyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-Lysinamide; N2-Acetyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; (S)-2-(2-((S)-2-acetamido-5-guanidinopentanamido)acetamido)-6-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide. Grades: ≥95%. CAS No. 660846-99-1. Molecular formula: C26H38N8O6. Mole weight: 558.64. | |
Ac-Gly-Ala-Lys-AMC Quick inquiry Where to buy Suppliers range | Ac-Gly-Ala-Lys-AMC is the control peptide for protease-coupled histone deacetylase (HDAC) assay with Ac-Gly-Ala-Lys(Ac)-AMC. Synonyms: Ac-GAK-AMC; N-Acetylglycyl-L-alanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; L-lysinamide, N-acetylglycyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-. Grades: ≥95%. CAS No. 1926163-46-3. Molecular formula: C23H31N5O6. Mole weight: 473.52. | |
Ac-Lys-AMC Quick inquiry Where to buy Suppliers range | Ac-Lys-AMC, also known as MAL, is a fluorescent substrate for histone deacetylases (HDACs). Synonyms: (S)-2-Acetamido-6-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide; N2-Acetyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; Hexanamide, 2-(acetylamino)-6-amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (2S)-. Grades: ≥98%. CAS No. 156661-42-6. Molecular formula: C18H23N3O4. Mole weight: 345.40. | |
ACY-775 Quick inquiry Where to buy Suppliers range | ACY-775 is a selective Histone Deacetylase 6 (HDAC6) inhbiitor with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 has the antidepressant-like properties of other HDAC inhibitors. Uses: Antidepressant. Synonyms: ACY-775; ACY 775; ACY775; 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide. Grades: 95%. CAS No. 1375466-18-4. Molecular formula: C17H19FN4O2. Mole weight: 330.36. | |
AN-7 Quick inquiry Where to buy Suppliers range | AN-7 is a novel histone deacetylase inhibitor (HDACI) with anticancer activity in several cell lines. Synonyms: 3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide. CAS No. 691410-93-2. Molecular formula: C19H34N2O2S4. Mole weight: 450.73. | |
APHA Compound 8 Quick inquiry Where to buy Suppliers range | APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor, which is in the same structural class as SAHA. The IC50 for mouse HDAC1 is 0.5 μM. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation. Synonyms: MC-1353; MC1353; MC 1353; APHA-8; APHA Compound 8; Aroyl pyrrole hydroxy amide #8; APHA 8; APHA8. Grades: ≥98%. CAS No. 676599-90-9. Molecular formula: C16H16N2O3. Mole weight: 284.3. | |
Apicidin Quick inquiry Where to buy Suppliers range | Apicidin is a fungal metabolite, as well as a histone deacetylase inhibitor. Uses: Microbial Fermentation Products. CAS No. 183506-66-3. Product ID: MFP-052. | |
Apicidin Quick inquiry Where to buy Suppliers range | Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 - 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin. Group: Biochemicals. Alternative Names: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl); Apicidin Ia; OSI 2040. Grades: Highly Purified. CAS No. 183506-66-3. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
Apicidin, Fusarium sp. Quick inquiry Where to buy Suppliers range | A potent, cell-permeable inhibitor of histone deacetylase (IC50= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG, 5MG. Mole weight: 623.78. Catalog: IAR42415437. Assay: ≥95% (HPLC). | |
AR-42 Quick inquiry Where to buy Suppliers range | AR-42 is an orally available, broad-spectrum deactylation inhibitor of both histone and non-histone proteins which play an important role in the regulation of gene expression, cell growth and survival. In preclinical studies, AR-42 has demonstrated greater potency and activity in solid and liquid tumors when compared to vorinostat and other deacetylase inhibitors. AR-42 is currently being studied in an investigator-initiated Phase I/IIa clinical study in adult patients with relapsed or refractory multiple myeloma, chronic lymphocytic leukemia or lymphoma. Synonyms: HDAC-42; HDAC42; HDAC 42; OSU-HDAC-42; OSU HDAC 42; AR-42; AR42; AR 42. Grades: 98%. CAS No. 935881-37-1. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
Belinostat Quick inquiry Where to buy Suppliers range | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Synonyms: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Molecular formula: C15H14N2O4S. Mole weight: 318.347. | |
β-Alanine methyl ester hydrochloride Quick inquiry Where to buy Suppliers range | β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Synonyms: β-Ala-OMe HCl; Methyl 3-aminopropanoate Hydrochloride; beta-Alanine methyl ester hydrochloride; h-beta-ala-ome hydrochloride; beta-alanine methyl ester HCl; 3-aminopropanoic acid methyl ester hydrochloride; Methyl beta-alaninate hydrochloride; 3-aminopropionic acid methyl ester hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 3196-73-4. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62. | |
β-Alanine Methyl Ester Hydrochloride Quick inquiry Where to buy Suppliers range | β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A (T774710) and Trapoxin B as histone deacetylase inhibitors. Group: Biochemicals. Alternative Names: (3-Methoxy-3-oxopropyl)ammonium Chloride; 3-Aminopropanoic Acid Methyl Ester Hydrochloride; 3-Aminopropionic Acid Methyl Ester Hydrochloride; 3-Aminopropionic Acid Methyl Ester Monohydrochloride; Methyl 3-Aminopropanoate Hydrochloride; Methyl 3-Aminopropionate Hydrochloride; Methyl β-Alaninate Hydrochloride. Grades: Highly Purified. CAS No. 3196-73-4. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
β-NADH, Reduced Disodium Salt (Nicotinamide Adenine Dinucleotide) Quick inquiry Where to buy Suppliers range | Beta-nicotinamide adenine dinucleotide hydrate. Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH. Grades: Highly Purified. CAS No. 606-68-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H27N7O14P2Na2, Molecular Weight: 709.41. US Biological Life Sciences. | Worldwide |
BMf-BH3 Quick inquiry Where to buy Suppliers range | BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death. Uses: Peptide Inhibitors. Product ID: R1239. | |
BML-210 Quick inquiry Where to buy Suppliers range | BML-210 is a Histone deacetylase (HDAC) inhibitor (IC50 = 87 μM), inducingchanges in gene expression profile. Uses: A histone deacetylase (hdac) inhibitor. Synonyms: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433N1-(2-aminophenyl)-N8-phenyloctanediamide; N-(2-aminophenyl)-N'-phenyl-octanediamide. Grades: ≥98%. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
Boc-Lys(Tfa)-AMC Quick inquiry Where to buy Suppliers range | Boc-Lys(Tfa)-AMC is a fluorogenic substrate for the assaying of histone deacetylase (HDAC) 4, 5 and 7 activity in a protease-coupled assay. Synonyms: tert-butyl N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxo-6-[(2,2,2-trifluoroacetyl)amino]hexan-2-yl]carbamate; (S)-tert-Butyl (1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-6-(2,2,2-trifluoroacetamido)hexan-2-yl)carbamate; Boc-L-Lys-MCA; Boc L Lys MCA. Grades: 98%. CAS No. 97885-44-4. Molecular formula: C23H28F3N3O6. Mole weight: 499.49. | |
BRD 9757 Quick inquiry Where to buy Suppliers range | BRD9757 is a potent and selective histone deacetylases 6 (HDAC6) inhibitor with IC50 of 30 nM. It displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold). Synonyms: N-Hydroxy-1-cyclopentene-1-carboxamide; BRD9757; BRD-9757. Grades: ≥98%. CAS No. 1423058-85-8. Molecular formula: C6H9NO2. Mole weight: 127.14. | |
Bufexamac Quick inquiry Where to buy Suppliers range | Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids. Group: Biochemicals. Alternative Names: 4-Butoxy-N-hydroxy Benzene acetamide; 2- (p-Butoxyphenyl) acetohydroxamic Acid; 4-Butoxyphenylacet hydroxamic Acid; Anderm; Bufexamic Acid; CP 1044J3; Droxarol; Droxaryl; Feximac; Flogocid; Flogocid N plastigel; Malipuran; Mofenar; Norfemac; Parfenac; Parfenal; Trolab; p-Butoxyphenylacet hydroxamic Acid; p-Butoxyphenylaceto hydroxamic Acid. Grades: Highly Purified. CAS No. 2438-72-4. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
CAY10398 Quick inquiry Where to buy Suppliers range | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. It has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing. Synonyms: MD 85; PX 089274. Grades: ≥98%. CAS No. 193551-00-7. Molecular formula: C15H23N3O3. Mole weight: 293.4. | |
CAY10591 Quick inquiry Where to buy Suppliers range | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10591 has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. It suppresses TNF-α in a dose-dependent manner. Uses: Enzyme activators. Synonyms: SIRT1 Activator 3; Sirtuin 1 Activator 3; CAY 10591; CAY-10591. Grades: ≥98%. CAS No. 839699-72-8. Molecular formula: C20H25N5O2. Mole weight: 367.5. | |
CAY10603 Quick inquiry Where to buy Suppliers range | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. Uses: Histone deacetylase inhibitors. Synonyms: CAY10603; CAY-10603; CAY 10603. Grades: >98%. CAS No. 1045792-66-2. Molecular formula: C22H30N4O6. Mole weight: 446.5. |