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Desipramine is an active metabolite of imipramine and has been found to be useful in the treatment of neuropathic pain. It may also be used to treat symptoms of cocaine withdrawal. Desipramine is a tricyclic antidepressant (TCA). Tricyclic antidepressants contain a characteristic three ringed nucleus structure. They act primarily as serotoninnorepinephri ne reuptake inhibitors. Tricyclic antidepressants are mainly used as antidepressants, but have also been for the treatment of anxiety disorders and attention hyperactivity disorder and as an adjunct to certain analgesics to treat chronic pain. In many treatments they have been replaced by other compounds with fewer sideeffects. Group: Biochemicals. Alternative Names: 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine-d4; G-35020-d4; JB-8181-d4; NSc-114901-d4; Norpramin-d4; Nortimil-d4; Pertofran-d4; Pertofrane-d4; Petylyl-d4. Grades: Highly Purified. CAS No. 61361-34-0. Pack Sizes: 1mg. US Biological Life Sciences.
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Desipramine-d3
Labeled tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. Group: Biochemicals. Alternative Names: 10,11-Dihydro-N-(methyl-d3)-5H-dibenz[b,f]azepine-5-propanamine; G-35020-d3; JB-8181-d3; NSC-114901-d3; Norpramin-d3; Nortimil-d3; Pertofran-d3; Pertofrane-d3; Petylyl-d3. Grades: Highly Purified. CAS No. 65100-49-4. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Desipramine-d4
Desipramine-d 4 is the deuterium labeled Desipramine[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 61361-34-0. Pack Sizes: 500 μg; 1 mg. Product ID: HY-B1272AS.
Desipramine Ethyl Carbamate
Desipramine Ethyl Carbamate is derived from 3-Dimethylaminopropyl Chloride Hydrochloride (D461800), which is is used mainly as a pharmaceutical intermediate for the synthesis of many types of drugs, as an agricultural chemical intermediate, as a photographic chemical intermediate, and as a biochemical reagent for enzyme and other studies. The compound shows mutagenic activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 27097-69-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C21H26N2O2, Molecular Weight: 338.44. US Biological Life Sciences.
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Desipramine HCl
Desipramine HCl can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections. Uses: Antidepressive agents, tricyclic. Synonyms: 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine. Grades: > 95%. CAS No. 58-28-6. Molecular formula: C18H23ClN2. Mole weight: 302.84.
Desipramine hydrochloride
Desipramine hydrochloride. Group: Biochemicals. Alternative Names: 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine; G-35020; JB-8181. Grades: Highly Purified. CAS No. 58-28-6. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C18H23ClN2, Molecular Weight: 302.84. US Biological Life Sciences.
Worldwide
Desipramine hydrochloride
Desipramine hydrochloride is an inhibitor of norepinephrine transporter ( NET ), 5-HT transporter ( SERT ) and dopamine transporter ( DAT ) with K i s of 4, 61 and 78,720 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 58-28-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B1272.
Desipramine impurity 1
Desipramine impurity 1. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C16H14N2O2. Mole Weight: 266.3. Catalog: APB11483.
Desipramine impurity 10
Desipramine impurity 10. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H8ClN3O2. Mole Weight: 285.69. Catalog: APB11489.
Desipramine impurity 11
Desipramine impurity 11. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H20ClN3O. Mole Weight: 329.83. Catalog: APB11491.
Desipramine impurity 12
Desipramine impurity 12. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H10N4O5. Mole Weight: 314.26. Catalog: APB11493.
Desipramine impurity 13
Desipramine impurity 13. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H11N3O3. Mole Weight: 296.26. Catalog: APB11494.
Desipramine impurity 14
Desipramine impurity 14. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H14N4O. Mole Weight: 254.29. Catalog: APB11495.
Desipramine impurity 15
Desipramine impurity 15. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C22H29ClN4O. Mole Weight: 400.95. Catalog: APB11496.
Desipramine impurity 2
Desipramine impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H13N3O. Mole Weight: 239.28. Catalog: APB11484.
Desipramine impurity 3
Desipramine impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 57164-17-7. Molecular Formula: C18H21N3O. Mole Weight: 295.39. Catalog: APB57164177.
Desipramine impurity 4
Desipramine impurity 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H19Cl2N3O. Mole Weight: 364.27. Catalog: APB11485.
Desipramine impurity 5
Desipramine impurity 5. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C22H29ClN4O. Mole Weight: 400.95. Catalog: APB11486.
Desipramine impurity 6
Desipramine impurity 6. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H18ClN3O. Mole Weight: 327.81. Catalog: APB11487.
Desipramine impurity 7
Desipramine impurity 7. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C16H15N3O2. Mole Weight: 281.32. Catalog: APB11488.
Desipramine impurity 8
Desipramine impurity 8. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H18N4O3. Mole Weight: 338.37. Catalog: APB11490.
Desipramine impurity 9
Desipramine impurity 9. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H16N2O3. Mole Weight: 308.34. Catalog: APB11492.
Desipramine (Norpramin®, Pertofrane®) (HRP)
Desipramine is an active metabolite of imipramine and has been found to be useful in the treatment of neuropathic pain. It may also be used to treat symptoms of cocaine withdrawal. Desipramine is a tricyclic antidepressant (TCA). Tricyclic antidepressants contain a characteristic three ringed nucleus structure. They act primarily as serotoninnorepinephri ne reuptake inhibitors. Tricyclic antidepressants are mainly used as antidepressants, but have also been for the treatment of anxiety disorders and attention hyperactivity disorder and as an adjunct to certain analgesics to treat chronic pain. In many treatments they have been replaced by other compounds with fewer sideeffects. Group: Biochemicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences.
Worldwide
10-Hydroxydesipramine
10-Hydroxydesipramine is a derivative of Desipramine, which is a relatively selective norepinephrine reuptake inhibitor used as a tricyclic antidepressant (TCA). Synonyms: 10-Hydroxydesmethylimipramine; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-10-ol; 5-[3-(Methylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepin-10-ol; 5H-Dibenz(b,f)azepin-10-ol, 10,11-dihydro-5-(3-(methylamino)propyl)-. Grades: ≥95%. CAS No. 4014-82-8. Molecular formula: C18H22N2O. Mole weight: 282.38.
2-Hydroxy Desipramine
A metabolite of Desipramine. Group: Biochemicals. Alternative Names: 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol; 2-Hydroxyde methyl imipramine; 2-Hydroxydes methyl imipramine; GP 36329. Grades: Highly Purified. CAS No. 1977-15-7. Pack Sizes: 1mg. US Biological Life Sciences.
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2-Hydroxydesipramine b-D-glucuronide sodium salt
2-Hydroxydesipramine b-D-glucuronide sodium salt, a highly significant compound in the biomedical industry, holds immense value for research endeavors. Its utilization encompasses the comprehensive exploration of desipramine metabolites to discern their pharmacological activities. Demonstrating remarkable promise, this derivative in sodium salt form finds wide application in the investigation of depression treatment approaches, facilitating the analysis of desipramine's metabolism and therapeutic effects. Molecular formula: C24H30N2O7·Na. Mole weight: 481.49.
2-Hydroxy Desipramine-d3
A labeled metabolite of Desipramine. Group: Biochemicals. Alternative Names: 10,11-Dihydro-5-[3-(methyl-d3-amino)propyl]-5H-dibenz[b,f]azepin-2-ol; 2-Hydroxyde methyl imipramine-d3; 2-Hydroxydes methyl imipramine-d3; GP 36329-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
2-Hydroxy Desipramine-d6 Hydrochloride
2-Hydroxy Desipramine-d6 Hydrochloride is a labeled salt analogue of 2-Hydroxy Desipramine (H936500), a metabolite of Desipramine Hydrochloride (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C18H17D6ClN2O, Molecular Weight: 324.88. US Biological Life Sciences.
Worldwide
2-Hydroxydesipramine Dihydrochloride
2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine, a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. Synonyms: 5H-Dibenz(b,f)azepin-2-ol, 10,11-dihydro-5-(3-(methylamino)propyl)-, hydrochloride (1:2); 5-[3-(Methylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepin-2-ol hydrochloride (1:2); 2-Hydroxydesmethylimipramine dihydrochloride; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol dihydrochloride. Molecular formula: C18H24Cl2N2O. Mole weight: 355.30.
2-Hydroxydesipramine Dihydrochloride
2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C18H22N2O 2HCl. US Biological Life Sciences.
Worldwide
2-Hydroxy desipramine glucuronide
A metabolite of Desipramine. Synonyms: 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-yl β-D-Glucopyranosiduronic Acid; 2-Hydroxydemethylimipramine Glucuronide; 2-Hydroxydesmethylimipramine Glucuronide. Grades: > 95%. CAS No. 25521-31-7. Molecular formula: C24H30N2O7. Mole weight: 458.50.
2-Hydroxydesipramine glucuronide HCl
2-Hydroxydesipramine glucuronide HCl, an indispensable compound in the biomedical sector, holds paramount significance. Its utilization spans the treatment of depression and associated ailments. Remarkably, it serves as a metabolite of desipramine, a pharmacological agent chiefly employed for its antidepressant qualities. Molecular formula: C24H30N2O7·HCl. Mole weight: 494.96 (free acid).
N-(3-Dimethylaminopropyl)desipramine DiHCl
Impurity of Desipramine HCl. Synonyms: N-[3-(10,11-Dihydro-5H-dibenzo-[b,f]azepin-5-yl)propyl]-N,N',N'-trimethylpropane-1,3-diamine Dihydrochloride. Grades: > 95%. CAS No. 1838-02-4. Molecular formula: C23H33N3·2HCl. Mole weight: 424.45.
3-Chloroiminodibenzyl
3-Chloroiminodibenzyl is a metabolite of Desipramine and Clomipramine. Group: Biochemicals. Alternative Names: 3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepine. Grades: Highly Purified. CAS No. 32943-25-2. Pack Sizes: 5g. US Biological Life Sciences.
Worldwide
(3-Methylaminopropyl)-5H-dibenz[b,f]azepine
(3-Methylaminopropyl)-5H-dibenz[b,f]azepine is an impurity of Desipramine, which is a relatively selective norepinephrine reuptake inhibitor used as a tricyclic antidepressant (TCA). Synonyms: N-Methyl-5H-dibenz[b,f]azepine-5-propanamine; 5-[3-(Methylamino)propyl]-5H-Dibenz[b,f]azepine; G 35967; 5H-Dibenz[b,f]azepine-5-propanamine, N-methyl-; Dehydrodesipramine. CAS No. 2010-13-1. Molecular formula: C18H20N2. Mole weight: 264.36.
Clomipramine HCl EP Impurity F
3-Chloroiminodibenzyl is a metabolite of Desipramine and Clomipramine. Synonyms: 3-Chloroiminodibenzyl; 3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepine. Grades: > 95%. CAS No. 32943-25-2. Molecular formula: C14H12ClN. Mole weight: 229.7.
Proadifen hydrochloride
Proadifen (SKF-525A) hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC 50 value of 19 μM. Proadifen hydrochloride reduces monoamine oxidase A ( MAO-A ) activity and reverses the antidepressantlike behavioral effect of Imipramine (HY-B1490A) and Desipramine (HY-B1272A) in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine ( DMT ) metabolism in liver microsomes and inhibits N-demethylationand Acridone (HY-W007771) formation. Proadifen hydrochloride augments Lipopolysaccharide (LPS) (HY-D1056)-induced fever and exacerbates Prostaglandin E2 (PGE2) (HY-101952) levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF-525A; U-5446; RP-5171. CAS No. 62-68-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-B1311.
Saredutant
Saredutant, aslo known as SR-48968, is a NK2 receptor antagonist for the treatment of major depressive disorder. Saredutant has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Synonyms: (S)-N-methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide. Grades: > 95%. CAS No. 142001-63-6. Molecular formula: C31H35Cl2N3O2. Mole weight: 552.55.
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