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| Product | Description | |
|---|---|---|
| Deucravacitinib | Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain ( IC 50 =1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis [1] [2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: BMS-986165. CAS No. 1609392-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117287. |  |
| Deucravacitinib | Deucravacitinib Inhibitor. Uses: Scientific use. Product Category: T14687. CAS No. 1609392-27-9. |  |
| BMS-986165 | BMS-986165 is a potent and selective TYK2 inhibitor that blocks signal transduction of IL-23, IL-12, and type I IFNs. It binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. BMS-986165 is under a phase III clinical trial for the treatment of Psoriasis. Synonyms: Deucravacitinib; BMS 986165; BMS986165; Tyk2-IN-4; Sotyktu. Grade: 98%. CAS No. 1609392-27-9. Molecular formula: C20H19D3N8O3. Mole weight: 425.47. |  |
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