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| Product | Description | |
|---|---|---|
| Dicoumarol | Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 ( NQO1 ) and PDK1 with IC 50 s of 0.37 and 19.42 μM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Dicumarol. CAS No. 66-76-2. Pack Sizes: 500 mg. Product ID: HY-N0645. |  |
| 2'-Hydroxy-3',4'-dimethylacetophenone | 2'-Hydroxy-3',4'-dimethylacetophenone is used for preparation of dicoumarol analogs as inhibitors of human NAD(P)H quinone oxidoreductase-1 (NQO1). Group: Biochemicals. Grades: Highly Purified. CAS No. 5384-55-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H12O2, Molecular Weight: 164.2. US Biological Life Sciences. |  Worldwide |
| Dicumarol-d8 | Dicumarol-d8. Group: Biochemicals. Alternative Names: Dicumol-d8; Dufalone-d8; Kumoran-d8; Melitoxin-d8; NC 034-d8; NSC 17860-d8; NSC 221570-d8; NSC 41834-d8; Temparin-d8; Trombosan-d8; 3,3'-Methylenebis[4-hydroxy-1,2-benzopyrone]-d8; 3,3'-Methylenebis[4-hydroxycoumarin]-d8; Acadyl-d8; Acavyl-d8; Antitrombosin-d8; Baracoumin-d8; Bis(4-hydroxycoumarin-3-yl)methane-d8; Bis-3, 3'- (4-hydroxycoumarinyl) methane-d8; Bishydroxycoumarin-d8; Cuma-d8; Cumid-d8; Di-4-hydroxy-3,3'-methylenedicoumarin-d8; Dicoumal-d8; Dicoumarin-d8; Dicoumarol-d8; Dicuman-d8; Dicumarine-d8; 3,3'-Methylenebis[4-hydroxycoumarin-d8; 3,3'-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one-d8. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C19H4D8O6, Molecular Weight: 336.29. US Biological Life Sciences. | Worldwide |
| ES 936 | ES 936 is a potent and specific NQO1 inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). NQO1 is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192820-78-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100367. | |
| NADH dehydrogenase (quinone) | Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. Group: Enzymes. Synonyms: reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase; NADH-quinone oxidoreductase; DPNH-menadione reductase; D-diaphorase; NADH2 dehydrogenase (quinone). Enzyme Commission Number: EC 1.6.5.11. CAS No. 37256-36-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1589; NADH dehydrogenase (quinone); EC 1.6.5.11; 37256-36-3; reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase; NADH-quinone oxidoreductase; DPNH-menadione reductase; D-diaphorase; NADH2 dehydrogenase (quinone). Cat No: EXWM-1589. |  |
| NAD(P)H dehydrogenase (quinone) | A flavoprotein. The enzyme catalyses a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. Group: Enzymes. Synonyms: menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; f. Enzyme Commission Number: EC 1.6.5.2. CAS No. 9032-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1591; NAD(P)H dehydrogenase (quinone); EC 1.6.5.2; 9032-20-6; menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD(P)H-quinone reductase; menadione oxidoreductase; NAD(P)H dehydrogenase; NAD(P)H menadione reductase; NAD(P)H-quinone dehydrogenase; NAD(P)H-quinone oxidoreductase; NAD(P)H: (quinone-acceptor)oxidoreductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase; naphthoquinone reductase; p-benzoquinone reductase; reduced NAD(P)H dehydrogenase; viologen accepting pyridine nucleotide oxidoreductase; vitamin K reductase; diaphorase; reduced nicotinamide-adenine dinucleotide (phosphate) dehy | |
| NADPH dehydrogenase (quinone) | A flavoprotein. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors.Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol. Group: Enzymes. Synonyms: reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase; NADPH oxidase; NADPH2 dehydrogenase (quinone). Enzyme Commission Number: EC 1.6.5.10. CAS No. 37256-37-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1588; NADPH dehydrogenase (quinone); EC 1.6.5.10; 37256-37-4; reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase; NADPH oxidase; NADPH2 dehydrogenase (quinone). Cat No: EXWM-1588. | |
| NADPH:quinone reductase | A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinonefree-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2. In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein ζ-crystallin. Group: Enzymes. Synonyms: NADPH2:quinone reductase. Enzyme Commission Number: EC 1.6.5.5. CAS No. 9032-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1594; NADPH:quinone reductase; EC 1.6.5.5; 9032-20-6; NADPH2:quinone reductase. Cat No: EXWM-1594. | |
| ribosyldihydronicotinamide dehydrogenase (quinone) | A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17β-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced. Group: Enzymes. Synonyms: NRH:quinone oxidoreductase 2; NQO2; NAD(P)H:quinone oxidoreductase-2 (misleading); QR2; quinone reductase 2; N-ribosyldihydronicotinamide dehydrogenase (quinone); NAD(P)H:quinone oxidoreductase2 (misleading). Enzyme Commission Number: EC 1.10.5.1. CAS No. 667919-86-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0488; ribosyldihydronicotinamide dehydrogenase (quinone); EC 1.10.5.1; 667919-86-0; NRH:quinone oxidoreductase 2; NQO2; NAD(P)H:quinone oxidoreductase-2 (misleading); QR2; quinone reductase 2; N-ribosyldihydronicotinamide dehydrogenase (quinone); NAD(P)H:quinone oxidoreductase2 (misleading). Cat No: EXWM-0488. | |
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