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| Product | Description | |
|---|---|---|
| (20R)-17α,20-Dihydroxycholesterol | (20R)-17α,20-Dihydroxycholesterol. Group: Biochemicals. Alternative Names: (3 β,20R)-Cholest-5-ene-3,17,20-triol; (20R)-Cholest-5-ene-3 β,17,20-triol. Grades: Highly Purified. CAS No. 17913-42-7. Pack Sizes: 100mg. Molecular Formula: C27H46O3, Molecular Weight: 418.65. US Biological Life Sciences. |  Worldwide |
| (20R)-17α,20-Dihydroxycholesterol-d7 | (20R)-17α,20-Dihydroxycholesterol-d7. Group: Biochemicals. Alternative Names: (3 β,20R)-Cholest-5-ene-3,17,20-triol-d7; (20R)-Cholest-5-ene-3 β,17,20-triol-d7. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C27H39D7O3, Molecular Weight: 425.7. US Biological Life Sciences. | Worldwide |
| (4α)-7-Dehydro-4,25-dihydroxycholesterol | Intermediate in the preparation of 4α,25-Dihydroxy Vitamin D3. Group: Biochemicals. Alternative Names: (3 β,4α)-Cholesta-5,7-diene-3,4,25-triol. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| (4 β)-7-Dehydro-4,25-dihydroxycholesterol | Intermediate in the preparation of 4 β,25-Dihydroxy Vitamin D3. Group: Biochemicals. Alternative Names: (3 β,4 β)-Cholesta-5,7-diene-3,4,25-triol. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 7α,24(R/S)-dihydroxycholesterol-d7 | 7α,24(R/S)-dihydroxycholesterol-d7. Group: Others. Purity: >99%. Mole weight: 425.695. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; sterols; sterols products; singnal transduction; cell pathways; 7α,24(R/S)-dihydroxycholesterol-d7; 7α,24(R/S)-dihydroxycholesterol-d7. Cat No: STEZ-031. |  |
| 7α,25-Dihydroxycholesterol | 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 ( EC 50 =140 pM; K d =450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 7α,25-OHC. CAS No. 64907-22-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113962. |  |
| 7α,25-Dihydroxycholesterol | 7α,25-Dihydroxycholesterol has been found to be an agonist of GPR183 and could desensitize B cells expressing GPR183 and reduce their movement to splenic follicles. Synonyms: 7alpha,25-OHC; (3β,7α)-Cholest-5-ene-3,7,25-triol; Cholest-5-ene-3beta,7alpha,25-triol; 5-Cholesten-3beta,7alpha,25-triol. Grades: ≥98% by HPLC. CAS No. 64907-22-8. Molecular formula: C27H46O3. Mole weight: 418.65. |  |
| 7α,25-dihydroxycholesterol-d6 | 7α,25-dihydroxycholesterol-d6. Group: Others. Synonyms: 26,26,26,27,27,27-hexadeutero-7α,25-dihydroxycholesterol. Purity: >99%. Mole weight: 424.689. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; sterols; sterols products; singnal transduction; cell pathways; 7α,25-dihydroxycholesterol-d6; 7α,25-dihydroxycholesterol-d6; 26,26,26,27,27,27-hexadeutero-7α,25-dihydroxycholesterol. Cat No: STEZ-032. | |
| 7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC) | A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450pM in a saturation binding analysis, and activates EBI2 (EC50=140pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-gamma assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-beta galactosidase cell line with an IC50 of 2nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 7α,27-Dihydroxycholesterol | 7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC). Uses: Scientific research. Group: Signaling pathways. CAS No. 4725-24-0. Pack Sizes: 1 mg. Product ID: HY-W414548. | |
| 7α,27-dihydroxycholesterol-d6 | 7α,27-dihydroxycholesterol-d6. Group: Others. Purity: >99%. Mole weight: 424.689. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; sterols; sterols products; singnal transduction; cell pathways; 7α,27-dihydroxycholesterol-d6; 7α,27-dihydroxycholesterol-d6. Cat No: STEZ-033. | |
| 7β,25-Dihydroxycholesterol | 7β,25-Dihydroxycholesterol is an endogenous metabolite and is found to act as chemoattractants for immune cells expressing EBI2 [1]. Uses: Scientific research. Group: Natural products. CAS No. 64907-21-7. Pack Sizes: 1 mg. Product ID: HY-N10493. | |
| 7ss,27-dihydroxycholesterol-d6 | 7ss,27-dihydroxycholesterol-d6. Group: Others. Purity: >99%. Mole weight: 424.689. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; sterols; sterols products; singnal transduction; cell pathways; 7ss,27-dihydroxycholesterol-d6; 7b,27-dihydroxycholesterol-d6. Cat No: STEZ-034. | |
| (3b,22R)-Dihydroxy cholesterol | (3b,22R)-Dihydroxy cholesterol. Group: Biochemicals. Alternative Names: (3b,22R)-Cholest-5-ene-3,20,22-triol; (22R)-Cholest-5-ene-3b,20,22-triol; (20R,22R)-20,22-Dihydroxycholesterol. Grades: Highly Purified. CAS No. 596-94-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C27H46O3. US Biological Life Sciences. | Worldwide |
| (3b,22S)-Dihydroxy cholesterol | (3b,22S)-Dihydroxy cholesterol. Group: Biochemicals. Alternative Names: (3b,22S)-Cholest-5-ene-3,20,22-triol; (22S)-Cholest-5-ene-3b,20,22-triol; (20R,22S)-20,22-Dihydroxycholesterol. Grades: Highly Purified. CAS No. 26649-05-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C27H46O3. US Biological Life Sciences. | Worldwide |
| 3 β,7α,25-Trihydroxycholest-5-ene | 3 β,7α,25-Trihydroxycholest-5-ene. Group: Biochemicals. Alternative Names: 7α,25-Dihydroxycholesterol; (3 β,7α)-Cholest-5-ene-3,7,25-triol. Grades: Highly Purified. CAS No. 64907-22-8. Pack Sizes: 2.5mg. Molecular Formula: C27H46O3, Molecular Weight: 418.65. US Biological Life Sciences. | Worldwide |
| cholesterol 24-hydroxylase | A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood-brain barrier whereas cholesterol cannot. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Enzyme Commission Number: EC 1.14.14.25. CAS No. 50812-30-1, 213327-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0922; cholesterol 24-hydroxylase; EC 1.14.14.25; 50812-30-1, 213327-78-7; cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Cat No: EXWM-0922. | |
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