Dioxygenase Suppliers USA
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Product | Description | |
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Indoleamine 2,3-dioxygenase 1 (199-207) Quick inquiry Where to buy Suppliers range | Indoleamine 2,3-dioxygenase 1. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-350. | |
Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 (388-401) Quick inquiry Where to buy Suppliers range | Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 (388-401) is a 14-aa peptide. Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 is a part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Synonyms: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (388-401). | |
Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 (388-401) Quick inquiry Where to buy Suppliers range | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-179. | |
1-Cyano-6-(methylsulfonyl)-7-nitro-9H-xanthen-9-one Quick inquiry Where to buy Suppliers range | 1-Cyano-6-(methylsulfonyl)-7-nitro-9H-xanthen-9-one is an impurity of Mesotrione (M225765), a herbicide that works by inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD), a crucial enzyme for the biosynthesis of carotenoid in plants. Mesotrione is also a synthetic analog of lepospermone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C15H8N2O6S. US Biological Life Sciences. | Worldwide |
1-Cyano-6-(methylsulfonyl)-9H-xanthen-9-one Quick inquiry Where to buy Suppliers range | 1-Cyano-6-(methylsulfonyl)-9H-xanthen-9-one is a related compound of Mesotrione (M225765), a herbicide that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H9NO4S, Molecular Weight: 299.3. US Biological Life Sciences. | Worldwide |
1-Methyl-D-tryptophan Quick inquiry Where to buy Suppliers range | 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression. Group: Biochemicals. Grades: Highly Purified. CAS No. 110117-83-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H14N2O2. US Biological Life Sciences. | Worldwide |
1-Methyl-L-tryptophan Quick inquiry Where to buy Suppliers range | 1-Methyl-L-tryptophan is a competitive inhibitor of indoleamine 2,3-dioxygenase (IDO). Synonyms: L-Abrine; 1-Methyl-L-tryptophan; H-Trp(1-Me)-OH; (S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; 1-Methyltryptophan; L-Tryptophan, 1-methyl-; UNII-XD0FY1J13B; XD0FY1J13B; (2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid. Grades: ≥ 98% (Chiral HPLC). CAS No. 21339-55-9. Molecular formula: C12H14N2O2. Mole weight: 218.26. | |
1-(Phenylsulfonyl)-3-indolylboronic Acid Pinacol Ester Quick inquiry Where to buy Suppliers range | 1-(Phenylsulfonyl)-3-indolylboronic Acid Pinacol Ester is used as a reactant in the preparation of 3- (2- (pyridyl) ethenyl) indoles that are tryptophan dioxygenase (TDO) inhibitors and potential anticancer immunomodulators. Group: Biochemicals. Grades: Highly Purified. CAS No. 870717-93-4. Pack Sizes: 500mg, 1g. Molecular Formula: C20H22BNO4S, Molecular Weight: 383.27. US Biological Life Sciences. | Worldwide |
2-(4-Hydroxyphenoxy)acetic Acid Quick inquiry Where to buy Suppliers range | 2-(4-Hydroxyphenoxy)acetic Acid is used in the design, synthesis and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hyroxyphenylpyruvate dioxygenase. Acts as a reagent in the preparation, anti-HIV and kinesin Eg5 inhibitory activities, QSAR, and modeling studies of triazolothiadiazole and triazolothiadiazine derivatives. Synthesis of thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 1878-84-8. Pack Sizes: 250mg, 1g. Molecular Formula: C8H8O4, Molecular Weight: 168.15. US Biological Life Sciences. | Worldwide |
2-(4-Nitrobenzyl)-2-thiopseudourea Hydrochloride Quick inquiry Where to buy Suppliers range | 2-(4-Nitrobenzyl)-2-thiopseudourea Hydrochloride is used in preparation of indoleamine dioxygenase and study SAR of benzylisothiourea derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 4357-96-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H9N3O2S; HCl, Molecular Weight: 211.243646. US Biological Life Sciences. | Worldwide |
2-Bromo-6- (3- (methylsulfonyl) -4-nitrophenoxy) benzaldehyde Quick inquiry Where to buy Suppliers range | 2-Bromo-6- (3- (methylsulfonyl) -4-nitrophenoxy) benzaldehyde is an intermediate in the synthesis of 1-Cyano-6-(methylsulfonyl)-7-nitro-9H-xanthen-9-one (C981885), which is an impurity of Mesotrione (M225765), a herbicide that works by inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD), a crucial enzyme for the biosynthesis of carotenoid in plants. Mesotrione is also a synthetic analog of lepospermone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500mg, 1g. Molecular Formula: C14H10BrNO6S. US Biological Life Sciences. | Worldwide |
2-Hydroxyethane phosphonic Acid-d4 Quick inquiry Where to buy Suppliers range | 2-Hydroxyethane phosphonic acid is an substrate used in the study of 2- hydroxyethyl phosphonate dioxygenase reaction mechanism. 2-Hydroxyethane phosphonic Acid is also a required intermediate in labelled Fosfomycin (F727502) biosynthesis. Group: Biochemicals. Alternative Names: P-(2-Hydroxyethyl)-phosphonic Acid-d4; (2-Hydroxyethyl) phosphonic Acid-d4. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
(2S)-Octyl-α-hydroxyglutarate Quick inquiry Where to buy Suppliers range | (2S)-Octyl-α-hydroxyglutarate is a cell permeable derivative of the L-isomer of 2-Hydroxyglutaric Acid (H942575), a potential inhibitor of glutamate carboxypeptidase. Also, being structurally similar to α-ketoglutarate, it competitively inhibits α-ketoglutarate dependent dioxygenases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-64-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5. US Biological Life Sciences. | Worldwide |
3-(1H-1,2,3-Triazol-4-yl)pyridine Quick inquiry Where to buy Suppliers range | 3-(1H-1,2,3-Triazol-4-yl)pyridine is a reactant used in the synthesis of 4-aryl-1H-1,2,3-triazoles which possesses more Indoleamine 2,3-dioxygenase (IDO) inhibitory potency than the most commonly used 1-methyltryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 120241-79-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H6N4, Molecular Weight: 146.15. US Biological Life Sciences. | Worldwide |
3, 5-Dioxocyclohexane carboxylic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | A reactant in the preparation of plant growth retardants and cyclopropane carbonyloxy cyclohexenone derivs. as hydroxyphenylpyruvate dioxygenase inhibitors. Group: Biochemicals. Alternative Names: Ethyl 3, 5-Dioxocyclohexane carboxylate. Grades: Highly Purified. CAS No. 27513-35-5. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
3- (Trifluoromethoxy) aniline Quick inquiry Where to buy Suppliers range | 3- (Trifluoromethoxy) aniline is reactant in the synthesis of pyrazolone-quinazolone hybrids as human hydroxyphenylpyruvate dioxygenase inhibitors which is a potential treatment for type I tyrosinemia. Group: Biochemicals. Grades: Highly Purified. CAS No. 1535-73-5. Pack Sizes: 1g, 10g. Molecular Formula: C7H6F3NO. US Biological Life Sciences. | Worldwide |
7-Methylindole-3-carboxaldehyde Quick inquiry Where to buy Suppliers range | A reactant used for the preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators, antibacterial agents, antiandrogens, anti-bovine viral diarrhea virus (BVDV) agents and so on. Synonyms: 7-Methyl-1H-indole-3-carbaldehyde. CAS No. 4771-50-0. Molecular formula: C10H9NO. Mole weight: 159.19. | |
BMS-986205 Quick inquiry Where to buy Suppliers range | BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. It is undergoing a phase I/II clinical trial for the bladder and cervical cancer therapy in combination with nivolumab, an anti-programmed cell death protein 1 (PD-1) monoclonal antibody. Uses: Drug combination with nivolumab. Synonyms: BMS-986205; BMS 986205; BMS986205; (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide. CAS No. 1923833-60-6. Molecular formula: C24H24ClFN2O. Mole weight: 410.917. | |
Brassinin Quick inquiry Where to buy Suppliers range | Brassinin is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 28 μM for human IDO) with antifungal and anticancer activities. Brassinin also inhibits IL-6-inducible STAT3 activation and attenuates tumor growth in a xenograft lung cancer mouse model. Brassinin is found in brassicas. Synonyms: Brassinine; CCG-208623; CCG208623; CCG 208623; HE-005916; HE005916; HE 005916; HE-292778; HE292778; HE292778; Methyl (1H-indol-3-ylmethyl)carbamodithioate. Grades: 98%. CAS No. 105748-59-2. Molecular formula: C11H12N2S2. Mole weight: 236.36. | |
Disodium (R)-2-Hydroxyglutarate Quick inquiry Where to buy Suppliers range | Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as a weak antagonist of α-KG to inhibit α-KG-dependent histone demethylases and increase dimethylation on both H3K9 and H3K79. Synonyms: MDK4906; MDK 4906; MDK-4906; d-α-hydroxyglutaric acid disodium salt; (2R)-2-Hydroxyglutaric Acid Disodium Salt; D-alpha-Hydroxyglutaric acid (disodium salt). Grades: 98%. CAS No. 103404-90-6. Molecular formula: C5H6Na2O5. Mole weight: 192.08. | |
IDO-IN-2 Quick inquiry Where to buy Suppliers range | IDO-IN-2 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM. Synonyms: IDO inhibitor 1; 1-[2-[bis(2-methylpropyl)amino]-5-[2-(2H-tetrazol-5-yl)phenyl]phenyl]-3-(4-methylphenyl)urea. CAS No. 1668565-74-9. Molecular formula: C29H35N7O. Mole weight: 497.63. | |
INCB024360-analog Quick inquiry Where to buy Suppliers range | Potent competitive inhibitor of IDO1 with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion. Synonyms: INCB-24360; INCB024360; INCB 024360; INCB-024360; indoleamine-2,3-dioxygenase inhibitor INCB024360. Grades: > 98%. CAS No. 914471-09-3. Molecular formula: C9H7ClFN5O2. Mole weight: 271.64. | |
Indoximod Quick inquiry Where to buy Suppliers range | A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Synonyms: NLG8189; NLG 8189; NLG-8189; D-1MT; 1-methyl-D-tryptophan; H-D-Trp(Me)-OH. Grades: > 98%. CAS No. 110117-83-4. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
L-Kynurenine Quick inquiry Where to buy Suppliers range | a product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses. Synonyms: L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. Grades: > 95%. CAS No. 2922-83-0. Molecular formula: C10H12N2O3. Mole weight: 208.22. | |
Necrostatin-1 Quick inquiry Where to buy Suppliers range | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
Nitisinone Quick inquiry Where to buy Suppliers range | Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I. Group: Biochemicals. Alternative Names: 2-[2-Nitro-4- (trifluoromethyl) benzoyl]-. Grades: Highly Purified. CAS No. 104206-65-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Nitisinone Quick inquiry Where to buy Suppliers range | Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. Uses: Enzyme inhibitors. Synonyms: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione; NTBC; Nitisone. Grades: >98%. CAS No. 104206-65-7. Molecular formula: C14H10F3NO5. Mole weight: 329.23. | |
Nitisinone-13C6 Quick inquiry Where to buy Suppliers range | Labeled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I. Group: Biochemicals. Alternative Names: 2-[2-Nitro-4- (trifluoromethyl) benzoyl]-. Grades: Highly Purified. CAS No. 1246815-63-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
NLG-919 Quick inquiry Where to buy Suppliers range | NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Synonyms: GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078. Grades: > 98%. CAS No. 1402836-58-1. Molecular formula: C18H22N2O. Mole weight: 282.38. | |
Palmatine chloride Quick inquiry Where to buy Suppliers range | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities. Group: Biobased Products. Alternative Names: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride. Grades: 98%. CAS No. 10605-02-4. Product ID: BBC10605024. Molecular formula: C21H22ClNO4. Mole weight: 387.86. IUPAC Name: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride. Appearance: Powder. SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC (=C (C=C4CC3)OC)OC)OC. [Cl-]. |