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The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). Group: Enzymes. Synonyms: MECDP-synthase; 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing). Enzyme Commission Number: EC 4.6.1.12. CAS No. 287480-92-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5349; 2-C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase; EC 4.6.1.12; 287480-92-6; MECDP-synthase; 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing). Cat No: EXWM-5349.
(2E,6E)-farnesyl diphosphatesynthase
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors. Group: Enzymes. Synonyms: farnesyl-diphosphatesynthase; geranyl transferase I; prenyltransferase; farnesyl pyrophosphate synthetase; farnesylpyrophosphate synthetase; geranyltranstransferase. Enzyme Commission Number: EC 2.5.1.10. CAS No. 37277-79-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2715; (2E,6E)-farnesyl diphosphatesynthase; EC 2.5.1.10; 37277-79-5; farnesyl-diphosphatesynthase; geranyl transferase I; prenyltransferase; farnesyl pyrophosphate synthetase; farnesylpyrophosphate synthetase; geranyltranstransferase. Cat No: EXWM-2715.
(2Z,6E)-farnesyl diphosphatesynthase
Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate. Group: Enzymes. Synonyms: (Z)-farnesyl diphosphatesynthase; Z-farnesyl diphosphatesynthase. Enzyme Commission Number: EC 2.5.1.68. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2805; (2Z,6E)-farnesyl diphosphatesynthase; EC 2.5.1.68; (Z)-farnesyl diphosphatesynthase; Z-farnesyl diphosphatesynthase. Cat No: EXWM-2805.
(2Z,6Z)-farnesyl diphosphatesynthase
This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphatesynthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphatesynthase]. Group: Enzymes. Synonyms: cis,cis-farnesyl diphosphatesynthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase. Enzyme Commission Number: EC 2.5.1.92. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2831; (2Z,6Z)-farnesyl diphosphatesynthase; EC 2.5.1.92; cis,cis-farnesyl diphosphatesynthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase. Cat No: EXWM-2831.
Requires Mn2+. Mg2+ is not effective. Some (-)-α-phellandrene is also formed. The reaction involves a 1,3-hydride shift. Group: Enzymes. Synonyms: phellandrene synthase; (-)-β-phellandrene synthase;(-)-(4S)-β-phellandrene synthase. Enzyme Commission Number: EC 4.2.3.52. CAS No. 137010-34-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5212; (4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing); EC 4.2.3.52; 137010-34-5; phellandrene synthase; (-)-β-phellandrene synthase;(-)-(4S)-β-phellandrene synthase. Cat No: EXWM-5212.
Isolated from the plant Solanum habrochaites. 7-Epizingiberene is a whitefly repellant. Group: Enzymes. Synonyms: ShZIS (gene name). Enzyme Commission Number: EC 4.2.3.142. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5156; 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.142; ShZIS (gene name). Cat No: EXWM-5156.
all-trans-decaprenyl-diphosphatesynthase
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: decaprenyl-diphosphatesynthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase. Enzyme Commission Number: EC 2.5.1.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2830; all-trans-decaprenyl-diphosphatesynthase; EC 2.5.1.91; decaprenyl-diphosphatesynthase; decaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-prenyltransferase. Cat No: EXWM-2830.
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation. Group: Enzymes. Synonyms: nonaprenyl diphosphatesynthase (ambiguous); solanesyl diphosphatesynthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphatesynthase (ambiguous); OsSPS2. Enzyme Commission Number: EC 2.5.1.84. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2822; all-trans-nonaprenyl-diphosphatesynthase [geranyl-diphosphate specific]; EC 2.5.1.84; nonaprenyl diphosphatesynthase (ambiguous); solanesyl diphosphatesynthase (ambiguous); SolPP synthase (ambiguous); SPP-synthase (ambiguous); SPP synthase (ambiguous); solanesyl-diphosphatesynthase (ambiguous); OsSPS2. Cat No: EXWM-2822.
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains. Group: Enzymes. Synonyms: nonaprenyl diphosphatesynthase (ambiguous); solanesyl diphosphatesynthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Enzyme Commission Number: EC 2.5.1.85. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2823; all-trans-nonaprenyl diphosphatesynthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.85; nonaprenyl diphosphatesynthase (ambiguous); solanesyl diphosphatesynthase (ambiguous); At-SPS2; At-SPS1; SPS1; SPS2. Cat No: EXWM-2823.
all-trans-octaprenyl-diphosphatesynthase
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: octaprenyl-diphosphatesynthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase. Enzyme Commission Number: EC 2.5.1.90. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2829; all-trans-octaprenyl-diphosphatesynthase; EC 2.5.1.90; octaprenyl-diphosphatesynthase; octaprenyl pyrophosphate synthetase; polyprenylpyrophosphate synthetase; terpenoidallyltransferase; terpenyl pyrophosphate synthetase; trans-heptaprenyltranstransferase; trans-prenyltransferase. Cat No: EXWM-2829.
The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-β-bergamotene (see EC 4.2.3.53) as well as (-)-endo-α-bergamotene (see EC 4.2.3.54). Small amounts of (-)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation. Group: Enzymes. Synonyms: SBS (ambiguous). Enzyme Commission Number: EC 4.2.3.50. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5210; (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.50; SBS (ambiguous). Cat No: EXWM-5210.
The enzyme from Solanum lycopersicum has very poor affinity with geranyl diphosphate as substrate. Catalyses the formation of the acyclic myrcene and ocimene as major products in addition to β-phellandrene. Group: Enzymes. Synonyms: phellandrene synthase 1; PHS1; monoterpene synthase PHS1. Enzyme Commission Number: EC 4.2.3.51. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5211; β-phellandrene synthase (neryl-diphosphate-cyclizing); EC 4.2.3.51; phellandrene synthase 1; PHS1; monoterpene synthase PHS1. Cat No: EXWM-5211.
(-)-bornyl diphosphatesynthase
Requires Mg2+. The enzyme from Tanacetum vulgare (tansy) can also use (3S)-linalyl diphosphate or more slowly neryl diphosphate in vitro. The reaction proceeds via isomeration of geranyl diphosphate to (3S)-linalyl diphosphate. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (-)-bornyl diphosphate. cf. EC 5.5.1.8 (+)-bornyl diphosphatesynthase. Group: Enzymes. Synonyms: bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (-)-bornyl pyrophosphate cyclase; bornyl diphosphatesynthase; geranyl-diphosphate cyclase (ambiguous); (-)-bornyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.22. CAS No. 110639-17-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5623; (-)-bornyl diphosphatesynthase; EC 5.5.1.22; 110639-17-3; bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (-)-bornyl pyrophosphate cyclase; bornyl diphosphatesynthase; geranyl-diphosphate cyclase (ambiguous); (-)-bornyl-diphosphate lyase (decyclizing). Cat No: EXWM-5623.
(+)-bornyl diphosphatesynthase
Requires Mg2+. The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro. The reaction proceeds via isomeration of geranyl diphosphate to (3R)-linalyl diphosphate. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate. cf. EC 5.5.1.22 [(-)-bornyl diphosphatesynthase]. Group: Enzymes. Synonyms: bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (+)-bornylpyrophosphate cyclase; geranyl-diphosphate cyclase (ambiguous); (+)-bornyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.8. CAS No. 72668-91-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5634; (+)-bornyl diphosphatesynthase; EC 5.5.1.8; 72668-91-8; bornyl pyrophosphate synthase (ambiguous); bornyl pyrophosphate synthetase (ambiguous); (+)-bornylpyrophosphate cyclase; geranyl-diphosphate cyclase (ambiguous); (+)-bornyl-diphosphate lyase (decyclizing). Cat No: EXWM-5634.
chrysanthemyl diphosphatesynthase
Requires a divalent metal ion for activity, with Mg2+ being better than Mn2+. Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis. Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums. Group: Enzymes. Synonyms: CPPase. Enzyme Commission Number: EC 2.5.1.67. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2804; chrysanthemyl diphosphatesynthase; EC 2.5.1.67; CPPase. Cat No: EXWM-2804.
copalyl diphosphatesynthase
In some plants, such as Salvia miltiorrhiza, this enzyme is monofunctional. In other plants this activity is often a part of a bifunctional enzyme. For example, in Selaginella moellendorffii this activity is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.131, miltiradiene synthase, while in the tree Abies grandis (grand fir) it is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.18, abietadiene synthase. Group: Enzymes. Synonyms: (+)-copalyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.12. CAS No. 157972-08-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5613; copalyl diphosphatesynthase; EC 5.5.1.12; 157972-08-2; (+)-copalyl-diphosphate lyase (decyclizing). Cat No: EXWM-5613.
The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated α-isoprene unit, which serves as a glycosyl carrier in protein glycosylation. The yeast Saccharomyces cerevisiae has two different enzymes that catalyse this reaction. Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C80 (16 isoprene residues) extending to C120, while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits. Largest Srt1p products reach C290. The enzyme from Arabidopsis thaliana catalyses the formation of polyprenyl diphosphates with predominant carbon number C120. Group: Enzymes. Synonyms: RER2; Rer2p; Rer2p Z-prenyltransferase; Srt1p; Srt2p Z-prenyltransferase; ACPT; dehydrodolichyl diphosphatesynthase 1. Enzyme Commission Number: EC 2.5.1.87. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2825; ditrans,polycis-polyprenyl diphosphatesynthase [(2E,6E)-farnesyl diphosphate specific]; EC 2.5.1.87; RER2; Rer2p; Rer2p Z-prenyltransferase; Srt1p; Srt2p Z-prenyltransferase; ACPT; dehydrodolichyl diphosphatesynthase 1. Cat No: EXWM-2825.
Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. Group: Enzymes. Synonyms: di-trans,poly-cis-undecaprenyl-diphosphatesynthase; undecaprenyl-diphosphatesynthase; bactoprenyl-diphosphatesynthase; UPP synthetase; undecaprenyl diphosphate synthetase; undecaprenyl pyrophosphate synthetase; di-trans,poly-cis-decaprenylcistransferase. Enzyme Commission Number: EC 2.5.1.31. CAS No. 52350-87-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2769; ditrans,polycis-undecaprenyl-diphosphatesynthase [(2E,6E)-farnesyl-diphosphate specific]; EC 2.5.1.31; 52350-87-5; di-trans,poly-cis-undecaprenyl-diphosphatesynthase; undecaprenyl-diphosphatesynthase; bactoprenyl-diphosphatesynthase; UPP synthetase; undecaprenyl diphosphate synthetase; undecaprenyl pyrophosphate synthetase; di-trans,poly-cis-decaprenylcistransferase. Cat No: EXWM-2769.
An iron-sulfur protein found in plant chloroplasts and cyanobacteria that contains a [4Fe-4S] cluster. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis. Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3). The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin. Group: Enzymes. Synonyms: 4-hydroxy-3-methylbut-2-en-1-yl diphosphatesynthase (ambiguous); (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect); (E)-4-hydroxy-3-methylbut-2-enyl diphosphatesynthase (ambiguous); gcpE (gene name); ISPG (gene name); (E)-4-hydroxy-3-methylbut-2-eny. Enzyme Commission Number: EC 1.17.7.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1096; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphatesynthase (ferredoxin); EC 1.17.7.1; 4-hydroxy-3-methylbut-2-en-1-yl diphosphatesynthase (ambiguous); (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect); (E)-4-hydroxy-3-methylbut-2-enyl diphosphatesynthase (ambiguous); gcpE (gene name); ISPG (gene name); (E)-4-hydroxy-3-methylbut-2-enyl-diphosphatesynthase. Cat No: EXWM-1096.
A bacterial iron-sulfur protein that contains a [4Fe-4S] cluster. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1). Group: Enzymes. Synonyms: 4-hydroxy-3-methylbut-2-en-1-yl diphosphatesynthase (ambiguous); (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect); (E)-4-hydroxy-3-methylbut-2-enyl diphosphatesynthase (ambiguous); ispG (gene name). Enzyme Commission Number: EC 1.17.7.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1098; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphatesynthase (flavodoxin); EC 1.17.7.3; 4-hydroxy-3-methylbut-2-en-1-yl diphosphatesynthase (ambiguous); (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect); (E)-4-hydroxy-3-methylbut-2-enyl diphosphatesynthase (ambiguous); ispG (gene name). Cat No: EXWM-1098.
The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-β-bergamotene (EC 4.2.3.53) as well as (-)-endo-α-bergamotene. Small amounts of (-)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation. Group: Enzymes. Synonyms: SBS (ambiguous). Enzyme Commission Number: EC 4.2.3.54. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5214; (-)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.54; SBS (ambiguous). Cat No: EXWM-5214.
The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (-)-endo-α-bergamotene (see EC 4.2.3.54), as well as (+)-endo-β-bergamotene. Small amounts of (-)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation. Group: Enzymes. Synonyms: SBS (ambiguous). Enzyme Commission Number: EC 4.2.3.53. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5213; (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]; EC 4.2.3.53; SBS (ambiguous). Cat No: EXWM-5213.
ent-copalyl diphosphatesynthase
Part of a bifunctional enzyme involved in the biosynthesis of kaurene. See also EC 4.2.3.19 (ent-kaurene synthase). Group: Enzymes. Synonyms: ent-kaurene synthase A; ent-kaurene synthetase A; ent-CDP synthase; ent-copalyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.13. CAS No. 9055-64-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5614; ent-copalyl diphosphatesynthase; EC 5.5.1.13; 9055-64-5; ent-kaurene synthase A; ent-kaurene synthetase A; ent-CDP synthase; ent-copalyl-diphosphate lyase (decyclizing). Cat No: EXWM-5614.
Isolated from the liverwort Heteroscyphus planus. cf EC 4.2.3.92 (+)-γ-cadinene synthase. Group: Enzymes. Synonyms: (-)-γ-cadinene cyclase. Enzyme Commission Number: EC 4.2.3.62. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5223; (-)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]; EC 4.2.3.62; (-)-γ-cadinene cyclase. Cat No: EXWM-5223.
geranylfarnesyl diphosphatesynthase
The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids. Group: Enzymes. Synonyms: FGPP synthase; (all-E) geranylfarnesyl diphosphatesynthase; GFPS; Fgs. Enzyme Commission Number: EC 2.5.1.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2819; geranylfarnesyl diphosphatesynthase; EC 2.5.1.81; FGPP synthase; (all-E) geranylfarnesyl diphosphatesynthase; GFPS; Fgs. Cat No: EXWM-2819.
geranylgeranyl diphosphatesynthase
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors. Group: Enzymes. Synonyms: geranylgeranyl-diphosphatesynthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete). Enzyme Commission Number: EC 2.5.1.29. CAS No. 9032-58-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2766; geranylgeranyl diphosphatesynthase; EC 2.5.1.29; 9032-58-0; geranylgeranyl-diphosphatesynthase; geranylgeranyl pyrophosphate synthetase; geranylgeranyl-PP synthetase; farnesyltransferase; geranylgeranyl pyrophosphate synthase; farnesyltranstransferase (obsolete). Cat No: EXWM-2766.
halimadienyl-diphosphatesynthase
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol). Group: Enzymes. Synonyms: Rv3377c; halimadienyl diphosphatesynthase; tuberculosinol diphosphatesynthase; halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing); halima-5,13-dien-15-yl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.16. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5617; halimadienyl-diphosphatesynthase; EC 5.5.1.16; Rv3377c; halimadienyl diphosphatesynthase; tuberculosinol diphosphatesynthase; halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing); halima-5,13-dien-15-yl-diphosphate lyase (decyclizing). Cat No: EXWM-5617.
heptaprenyl diphosphatesynthase
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry. Group: Enzymes. Synonyms: all-trans-heptaprenyl-diphosphatesynthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase. Enzyme Commission Number: EC 2.5.1.30. CAS No. 74506-59-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2768; heptaprenyl diphosphatesynthase; EC 2.5.1.30; 74506-59-5; all-trans-heptaprenyl-diphosphatesynthase; heptaprenyl pyrophosphate synthase; heptaprenyl pyrophosphate synthetase; HepPP synthase; HepPS; heptaprenylpyrophosphate synthetase. Cat No: EXWM-2768.
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Group: Enzymes. Synonyms: HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphatesynthase (ambiguous). Enzyme Commission Number: EC 2.5.1.83. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2821; hexaprenyl-diphosphatesynthase [(2E,6E)-farnesyl-diphosphate specific]; EC 2.5.1.83; HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphatesynthase (ambiguous). Cat No: EXWM-2821.
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+. Group: Enzymes. Synonyms: HexPS(ambiguous); (all-E) hexaprenyl diphosphatesynthase; (all-trans) hexaprenyl diphosphatesynthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphatesynthase (ambiguous). Enzyme Commission Number: EC 2.5.1.82. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2820; hexaprenyl diphosphatesynthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.82; HexPS(ambiguous); (all-E) hexaprenyl diphosphatesynthase; (all-trans) hexaprenyl diphosphatesynthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphatesynthase (ambiguous). Cat No: EXWM-2820.
lavandulyl diphosphatesynthase
Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphatesynthase) when dimethylally diphosphate is the sole substrate. Group: Enzymes. Synonyms: FDS-5. Enzyme Commission Number: EC 2.5.1.69. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2806; lavandulyl diphosphatesynthase; EC 2.5.1.69; FDS-5. Cat No: EXWM-2806.
presqualene diphosphatesynthase
Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase). Group: Enzymes. Synonyms: SSL-1 (gene name); hpnD (gene name). Enzyme Commission Number: EC 2.5.1.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2719; presqualene diphosphatesynthase; EC 2.5.1.103; SSL-1 (gene name); hpnD (gene name). Cat No: EXWM-2719.
syn-copalyl-diphosphatesynthase
Requires a divalent metal ion, preferably Mg2+, for activity. This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme is constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighbouring plants). In other tissues the enzyme is upregulated by conditions that stimulate the biosynthesis of phytoalexins. Group: Enzymes. Synonyms: OsCyc1; OsCPSsyn; syn-CPP synthase; syn-copalyl diphosphatesynthase; 9α-copalyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.14. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5615; syn-copalyl-diphosphatesynthase; EC 5.5.1.14; OsCyc1; OsCPSsyn; syn-CPP synthase; syn-copalyl diphosphatesynthase; 9α-copalyl-diphosphate lyase (decyclizing). Cat No: EXWM-5615.
terpentedienyl-diphosphatesynthase
Requires Mg2+. Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP). The triggering proton is lost at the end of the cyclization reaction. The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36, terpentetriene synthase and is a precursor of the diterpenoid antibiotic terpentecin. Group: Enzymes. Synonyms: terpentedienol diphosphatesynthase; Cyc1; clerodadienyl diphosphatesynthase; terpentedienyl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5616; terpentedienyl-diphosphatesynthase; EC 5.5.1.15; terpentedienol diphosphatesynthase; Cyc1; clerodadienyl diphosphatesynthase; terpentedienyl-diphosphate lyase (decyclizing). Cat No: EXWM-5616.
trans,polycis-decaprenyl diphosphatesynthase
The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan. Group: Enzymes. Synonyms: Rv2361c; (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphatesynthase. Enzyme Commission Number: EC 2.5.1.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2824; trans,polycis-decaprenyl diphosphatesynthase; EC 2.5.1.86; Rv2361c; (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphatesynthase. Cat No: EXWM-2824.
Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.88. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2826; trans,polycis-polyprenyl diphosphatesynthase [(2Z,6E)-farnesyl diphosphate specific]; EC 2.5.1.88. Cat No: EXWM-2826.
This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2827; tritrans,polycis-undecaprenyl-diphosphatesynthase [geranylgeranyl-diphosphate specific]; EC 2.5.1.89. Cat No: EXWM-2827.
(13E)-labda-7,13-dien-15-ol synthase
The enzyme from the lycophyte Selaginella moellendorffii is bifunctional, initially forming (13E)-labda-7,13-dien-15-yl diphosphate, which is hydrolysed to the alcohol. Group: Enzymes. Synonyms: labda-7,13E-dien-15-ol synthase. Enzyme Commission Number: EC 3.1.7.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3761; (13E)-labda-7,13-dien-15-ol synthase; EC 3.1.7.10; labda-7,13E-dien-15-ol synthase. Cat No: EXWM-3761.
1,4-dihydroxy-2-naphthoate polyprenyltransferase
This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphatesynthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein, with the C-terminus located in the periplasm. It is highly specific for DHNA but not for a specific length of the prenyl chain. Group: Enzymes. Enzyme Commission Number: EC 2.5.1.74. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2812; 1,4-dihydroxy-2-naphthoate polyprenyltransferase; EC 2.5.1.74. Cat No: EXWM-2812.
15-cis-phytoene synthase
Requires Mn2+ for activity. The enzyme produces 15-cis-phytoene. cf. EC 2.5.1.99, 15-trans-phytoene synthase. Group: Enzymes. Synonyms: prephytoene-diphosphatesynthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous). Enzyme Commission Number: EC 2.5.1.32. CAS No. 50936-61-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2770; 15-cis-phytoene synthase; EC 2.5.1.32; 50936-61-3; prephytoene-diphosphatesynthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous). Cat No: EXWM-2770.
1,8-cineole synthase
Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and α-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate. Group: Enzymes. Synonyms: 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase. Enzyme Commission Number: EC 4.2.3.108. CAS No. 110637-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5119; 1,8-cineole synthase; EC 4.2.3.108; 110637-19-9; 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase. Cat No: EXWM-5119.
1-deoxy-D-xylulose-5-phosphate synthase
Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here). Group: Enzymes. Synonyms: 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating); DXP-synthase. Enzyme Commission Number: EC 2.2.1.7. CAS No. 202218-79-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2034; 1-deoxy-D-xylulose-5-phosphate synthase; EC 2.2.1.7; 202218-79-9; 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating); DXP-synthase. Cat No: EXWM-2034.
2-hydroxy-3-oxoadipate synthase
The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate. Group: Enzymes. Synonyms: 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating); α-ketoglutaric-glyoxylic carboligase; oxoglutarate: glyoxylate carboligase. Enzyme Commission Number: EC 2.2.1.5. CAS No. 9054-72-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2032; 2-hydroxy-3-oxoadipate synthase; EC 2.2.1.5; 9054-72-2; 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating); α-ketoglutaric-glyoxylic carboligase; oxoglutarate: glyoxylate carboligase. Cat No: EXWM-2032.
2-oxoacid oxidoreductase (ferredoxin)
Contains thiamine diphosphate and [4Fe-4S] clusters. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For example, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). Group: Enzymes. Synonyms: OFOR. Enzyme Commission Number: EC 1.2.7.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1225; 2-oxoacid oxidoreductase (ferredoxin); EC 1.2.7.11; OFOR. Cat No: EXWM-1225.
2-oxoglutarate synthase
The enzyme contains thiamine diphosphate and two [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). Group: Enzymes. Synonyms: 2-ketoglutarate ferredoxin oxidoreductase; 2-oxoglutarate:ferredoxin oxidoreductase; KGOR; 2-oxoglutarate ferredoxin oxidoreductase; 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating). Enzyme Commission Number: EC 1.2.7.3. CAS No. 37251-05-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1226; 2-oxoglutarate synthase; EC 1.2.7.3; 37251-05-1; 2-ketoglutarate ferredoxin oxidoreductase; 2-oxoglutarate:ferredoxin oxidoreductase; KGOR; 2-oxoglutarate ferredoxin oxidoreductase; 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating). Cat No: EXWM-1226.
3-acetyloctanal synthase
Requires thiamine diphosphate. The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin. The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction. In vitro the enzyme can act on a number of α,β-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyse both 1-2 and 1-4 carboligations depending on the substrate. Group: Enzymes. Synonyms: pigD (gene name). Enzyme Commission Number: EC 2.2.1.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2028; 3-acetyloctanal synthase; EC 2.2.1.12; pigD (gene name). Cat No: EXWM-2028.
The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters. Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-pentanoate, 2-oxobutyrate and 3-methylthiopropanamine. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase, and EC 1.2.7.3, 2-oxoglutarate synthase. Group: Enzymes. Synonyms: 2-ketoisovalerate ferredoxin reductase; 3-methyl-2-oxobutanoate synthase (ferredoxin); VOR; branched-chain ketoacid ferredoxin reductase; branched-chai. Enzyme Commission Number: EC 1.2.7.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1230; 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); EC 1.2.7.7; 2-ketoisovalerate ferredoxin reductase; 3-methyl-2-oxobutanoate synthase (ferredoxin); VOR; branched-chain ketoacid ferredoxin reductase; branched-chain oxo acid ferredoxin reductase; keto-valine-ferredoxin oxidoreductase; ketoisovalerate ferredoxin reductase; 2-oxoisovalerate ferredoxin reductase. Cat No: EXWM-1230.
4-hydroxy-3-polyprenylbenzoate decarboxylase
The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphatesynthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase. Group: Enzymes. Synonyms: ubiD (gene name); 4-hydroxy-3-solanesylbenzoate decarboxylase; 3-octaprenyl-4-hydroxybenzoate decarboxylase. Enzyme Commission Number: EC 4.1.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4848; 4-hydroxy-3-polyprenylbenzoate decarboxylase; EC 4.1.1.98; ubiD (gene name); 4-hydroxy-3-solanesylbenzoate decarboxylase; 3-octaprenyl-4-hydroxybenzoate decarboxylase. Cat No: EXWM-4848.
(4S)-limonene synthase
A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. Group: Enzymes. Synonyms: (-)-(4S)-limonene synthase; 4S-(-)-limonene synthase; geranyldiphosphatediphosphate lyase (limonene forming); geranyldiphosphatediphosphate lyase [cyclizing, (4S)-limonene-forming]; geranyl-diphosphatediphosphate-lyase [cyclizing; (-)-(4S)-limonene-forming]. Enzyme Commission Number: EC 4.2.3.16. CAS No. 110639-20-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5172; (4S)-limonene synthase; EC 4.2.3.16; 110639-20-8; (-)-(4S)-limonene synthase; 4S-(-)-limonene synthase; geranyldiphosphatediphosphate lyase (limonene forming); geranyldiphosphatediphosphate lyase [cyclizing, (4S)-limonene-forming]; geranyl-diphosphatediphosphate-lyase [cyclizing; (-)-(4S)-limonene-forming]. Cat No: EXWM-5172.
Used in the preparation of aromatic bisphosphonates as inhibitors of geranylgeranyl diphosphatesynthase. Group: Biochemicals. Alternative Names: 4-Bromobenzyl dimethyl-tert-butylsilyl Ether; (4-Bromobenzyl)oxy](tert-butyl)dimethylsilane; 1-Bromo-4- [ [ [ (1, 1-dimethylethyl) dimethylsilyl] oxy] methyl] -benzene. Grades: Highly Purified. CAS No. 87736-74-1. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
7-dimethylallyltryptophan synthase
This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase), but similar to that enzyme, accepts only dimethylallyl diphosphate as the prenyl donor. Group: Enzymes. Synonyms: 7-DMATS. Enzyme Commission Number: EC 2.5.1.80. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2818; 7-dimethylallyltryptophan synthase; EC 2.5.1.80; 7-DMATS. Cat No: EXWM-2818.
abieta-7,13-diene synthase
Part of a bifunctional enzyme involved in the biosynthesis of abietadiene. See also EC 5.5.1.12, copalyl diphosphatesynthase. Requires Mg2+. Group: Enzymes. Synonyms: copalyl-diphosphatediphosphate-lyase (cyclizing) (ambiguous); abietadiene synthase (ambiguous). Enzyme Commission Number: EC 4.2.3.18. CAS No. 157972-08-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5174; abieta-7,13-diene synthase; EC 4.2.3.18; 157972-08-2; copalyl-diphosphatediphosphate-lyase (cyclizing) (ambiguous); abietadiene synthase (ambiguous). Cat No: EXWM-5174.
acetoin-ribose-5-phosphate transaldolase
A thiamine-diphosphate protein. Group: Enzymes. Synonyms: 1-deoxy-D-altro-heptulose-7-phosphate synthetase; 1-deoxy-D-altro-heptulose-7-phosphate synthase; 3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase [wrong substrate name]. Enzyme Commission Number: EC 2.2.1.4. CAS No. 87843-76-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2031; acetoin-ribose-5-phosphate transaldolase; EC 2.2.1.4; 87843-76-3; 1-deoxy-D-altro-heptulose-7-phosphate synthetase; 1-deoxy-D-altro-heptulose-7-phosphate synthase; 3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase [wrong substrate name]. Cat No: EXWM-2031.
acetolactate synthase
This enzyme requires thiamine diphosphate. The reaction shown is in the pathway of biosynthesis of valine; the enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. Group: Enzymes. Synonyms: α-acetohydroxy acid synthetase; α-acetohydroxyacid synthase; α-acetolactate synthase; α-acetolactate synthetase; acetohydroxy acid synthetase; acetohydroxyacid synthase; acetolactate pyruvate-lyase (carboxylating); acetolactic synthetase. Enzyme Commission Number: EC 2.2.1.6. CAS No. 9027-45-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2033; acetolactate synthase; EC 2.2.1.6; 9027-45-6; α-acetohydroxy acid synthetase; α-acetohydroxyacid synthase; α-acetolactate synthase; α-acetolactate synthetase; acetohydroxy acid synthetase; acetohydroxyacid synthase; acetolactate pyruvate-lyase (carboxylating); acetolactic synthetase. Cat No: EXWM-2033.
Adenosine 5'-diphosphate monopotassium salt
Adenosine 5'-diphosphate (ADP) is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5' position. It is produced by dephosphorylation of adenosine 5'-triphosphate by ATPases and can be converted back to ATP by ATP synthases. Synonyms: Adenosine 5'-(trihydrogen diphosphate), monopotassium salt; Adenosine 5'-Diphosphate Potassium Salt; 5'-ADP monopotassium salt; ADP monopotassium salt. Grades: ≥95%. CAS No. 70285-70-0. Molecular formula: C10H14N5O10P2·K. Mole weight: 465.29.
Adenosine 5'-triphosphate (ATP) Disodium Salt
Adenosine-5'-triphosphate is a nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism. It is one of the end products of photophosphorylation, cellular respiration, and fermentation and used by enzymes and structural proteins in many cellular processes, including biosynthetic reactions, motility, and cell division. One molecule of ATP contains three phosphate groups, and it is produced by a wide variety of enzymes, including ATP synthase, from adenosine diphosphate (ADP) or adenosine monophosphate (AMP) and various phosphate group donors. Substrate level phosphorylation, oxidative phosphorylation in cellular respiration, and photophosphorylation in photosynthesis are three major mechanisms of ATP biosynthesis. Group: Coenzymes. Synonyms: ATP; ATP-Na2; ATP-II; ATP-2. CAS No. 56-65-5. Purity: > 95% (Enzymatic). ATP. Mole weight: 551.2. Storage: Store at -20°C. Form: Crystalline. ATP; ATP-Na2; ATP-II; ATP-2; Adenosine 5'-triphosphate (ATP) Disodium Salt; Adenosine 5'-triphosphate Disodium Salt. Cat No: NATE-0945.
adenylate dimethylallyltransferase
Involved in the biosynthesis of cytokinins in plants. Some isoforms from the plant Arabidopsis thaliana are specific for AMP while others also have the activity of EC 2.5.1.112, adenylate dimethylallyltransferase (ADP/ATP-dependent). Group: Enzymes. Synonyms: cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:AMP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); IPT. Enzyme Commission Number: EC 2.5.1.27. CAS No. 72840-95-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2764; adenylate dimethylallyltransferase; EC 2.5.1.27; 72840-95-0; cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:AMP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); IPT. Cat No: EXWM-2764.
Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP. Other isoforms, such as IPT1 from Arabidopsis thaliana and the enzyme from the common hop, Humulus lupulus, also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase). Group: Enzymes. Synonyms: cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT. Enzyme Commission Number: EC 2.5.1.112. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2728; adenylate dimethylallyltransferase (ADP/ATP-dependent); EC 2.5.1.112; cytokinin synthase (ambiguous); isopentenyltransferase (ambiguous); 2-isopentenyl-diphosphate:ADP/ATP Δ2-isopentenyltransferase; adenylate isopentenyltransferase (ambiguous); dimethylallyl diphosphate:ATP/ADP isopentenyltransferase: IPT. Cat No: EXWM-2728.
adenylosuccinate synthase
In molecular biology, Adenylosuccinate synthase (EC 6.3.4.4.) is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP), phosphate and N(6)-(1,2-dicarboxyethyl)-AMP. Group: Enzymes. Synonyms: IMP-aspartate ligase; adenylosuccinate synthetase; succinoadenylic kinosynthetase; succino-AMP synthetase. Enzyme Commission Number: EC 6.3.4.4. CAS No. 9023-57-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5796; adenylosuccinate synthase; EC 6.3.4.4; 9023-57-8; IMP-aspartate ligase; adenylosuccinate synthetase; succinoadenylic kinosynthetase; succino-AMP synthetase. Cat No: EXWM-5796.
Alendronate sodium hydrate
Alendronate (sodium hydrate) is a farnesyl diphosphatesynthase inhibitor with IC 50 of 460 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Alendronate; MK 217; G-704650 Adronat. CAS No. 121268-17-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-11101.
Alendronate sodium (MK 217)
Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphatesynthase (FPPS) in the HMG-CoA pathway (IC50 = 460nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts. Group: Biochemicals. Alternative Names: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt. Grades: Purified. CAS No. 129318-43-0. Pack Sizes: 50mg. US Biological Life Sciences.
Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC?? value of 2nm. Also acts as a farnesyl diphosphatesynthase inhibitor (IC?? =460nm) and CD45 protein tyrosine phosphatase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 121268-17-5. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Alendronic acid
Alendronic acid, a bisphosphonate, is a farnesyl diphosphatesynthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Pagets disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66376-36-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0631.
all-trans-phytoene synthase
Requires Mn2+ for activity. The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene. cf. EC 2.5.1.32, 15-cis-phytoene synthase. Group: Enzymes. Synonyms: prephytoene-diphosphatesynthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous); 15-trans-phytoene synthase. Enzyme Commission Number: EC 2.5.1.99. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2838; all-trans-phytoene synthase; EC 2.5.1.99; prephytoene-diphosphatesynthase (ambiguous); phytoene synthetase (ambiguous); PSase (ambiguous); geranylgeranyl-diphosphate geranylgeranyltransferase (ambiguous); 15-trans-phytoene synthase. Cat No: EXWM-2838.
α,α-trehalose-phosphate synthase (UDP-forming)
See also EC 2.4.1.36 [α,α-trehalose-phosphate synthase (GDP-forming)]. Group: Enzymes. Synonyms: UDP-glucose-glucose-phosphate glucosyltransferase; trehalosephosphate-UDP glucosyltransferase; UDP-glucose-glucose-phosphate glucosyltransferase; α,α-trehalose phosphate synthase (UDP-forming); phosphotrehalose-uridine diphosphate transglucosylase; trehalose 6-phosphate synthase; trehalose 6-phosphate synthetase; trehalose phosphate synthase; trehalose phosphate synthet. Enzyme Commission Number: EC 2.4.1.15. CAS No. 9030-7-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2376; α,α-trehalose-phosphate synthase (UDP-forming); EC 2.4.1.15; 9030-07-3; UDP-glucose-glucose-phosphate glucosyltransferase; trehalosephosphate-UDP glucosyltransferase; UDP-glucose-glucose-phosphate glucosyltransferase; α,α-trehalose phosphate synthase (UDP-forming); phosphotrehalose-uridine diphosphate transglucosylase; trehalose 6-phosphate synthase; trehalose 6-phosphate synthetase; trehalose phosphate synthase; trehalose phosphate synthetase; trehalose phosphate-uridine diphosphate glucosyltransferase; trehalose-P synthetase; transglucosylase; uridine diphosphoglucose phosphate glucosyltransferase. Cat No: EXWM-2376.
α-bisabolene synthase
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding. Group: Enzymes. Synonyms: bisabolene synthase. Enzyme Commission Number: EC 4.2.3.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5196; α-bisabolene synthase; EC 4.2.3.38; bisabolene synthase. Cat No: EXWM-5196.
α-farnesene synthase
Alpha-farnesene synthase (EC 4.2.3.46) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate lyase ((3E,6E)-alpha-farnesene-forming). Group: Enzymes. Synonyms: (E,E)-α-farnesene synthase; AFS1; MdAFS1. Enzyme Commission Number: EC 4.2.3.46. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5205; α-farnesene synthase; EC 4.2.3.46; (E,E)-α-farnesene synthase; AFS1; MdAFS1. Cat No: EXWM-5205.
(-)-α-pinene synthase
Cyclase II of Salvia officinalis (sage) gives about equal parts (-)-α-pinene, (-)-β-pinene and (-)-camphene, plus traces of other monoterpenoids. (3S)-Linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate. The 4-pro-S-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+). The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-α-pinene and (-)-β-pinene. However the clone ag11 gave 35% (-)-limonene, 24% (-)-α-pinene and 20% (-)-β-phellandrene. It requires Mn2+ and K+ (Mg2+ is ineffective). Synthase I from Pinus taeda (loblolly pine) produces (-)-α-pinene with traces...ve roughly equal proportions of (-)-α-pinene and (-)-camphene plus traces of other monoterpenoids. See also EC 4.2.3.120, (-)-β-pinene synthase; EC 4.2.3.117, (-)-camphene synthase; EC 4.2.3.16, (-)-limonene synthase; and EC 4.2.3.52, (-)-β-phellandrene synthase. Group: Enzymes. Synonyms: (-)-α-pinene/(-)-camphene synthase; (-)-α-pinene cyclase. Enzyme Commission Number: EC 4.2.3.119. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5131; (-)-α-pinene synthase; EC 4.2.3.119; (-)-α-pinene/(-)-camphene synthase; (-)-α-pinene cyclase. Cat No: EXWM-5131.
(+)-α-pinene synthase
Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-α-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-α-pinene and (+)-β-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. The 4-pro-R-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+). With synthase II of Pinus taeda (loblolly pine) (+)-α-pinene was the only product. Requires Mn2+ (preferred to Mg2+). See also EC 4.2.3.122, (+)-β-pinene synthase, and EC 4.2.3.116, (+)-camphene synthase. Group: Enzymes. Synonyms: (+)-α-pinene cyclase; cyclase I. Enzyme Commission Number: EC 4.2.3.121. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5134; (+)-α-pinene synthase; EC 4.2.3.121; (+)-α-pinene cyclase; cyclase I. Cat No: EXWM-5134.
α-santalene synthase
The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (+)-α-santalene, (-)-β-santalene and (-)-exo-α-bergamotene are formed with traces of (+)-epi-β-santalene. See EC 4.2.3.83 [(-)-β-santalene synthase], and EC 4.2.3.81 [(-)-exo-α-bergamotene synthase]. cf. EC 4.2.3.50 α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.82. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5245; α-santalene synthase; EC 4.2.3.82. Cat No: EXWM-5245.
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