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| Product | Description | |
|---|---|---|
| Doxorubicin Liposome (PEGylated) | This formulation of doxorubicin liposome is PEGylated, which is only for research purposes and for the injection to laboratory animals. Doxorubicin drug is encapsulated into the liposome using remote loading by ammonium sulfate gradient. The formulation is ready for injection. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Amine-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the amine group, which can react with peptides, antibodies and other NHS-containing biomolecules or nanoparticles. The free carboxyl group on the antibody, peptide or protein can be activated by EDC/sulfo-NHS, and then covalently conjugated to the lipids through displacement of sulfo-NHS groups by amine groups of the liposome. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Azide-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the azide group, which can react with an dibenzocyclooctyne (DBCO) by click chemistry. The conjugation chemistry is based on the reaction of the azide reagent with an DBCO linker to form a stable triazole. DBCO moiety can be on the antibody and azide moiety can be on liposome and vice versa. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Biotin-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the biotin group. Biotinylated liposome can be conjugated noncovalently with (strept)avidin through either direct interaction with the protein/antibody conjugated to (strept)avidin or by coupling with other biotinylated proteins using (strept)avidin as a bridging molecule. Both avidin and (strept)avidin form strong noncovalent bond with biotin. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Carboxylic Acid-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the carboxyl group, which can be activated by EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide) and react with sulfo-NHS (N-hydroxysulfosuccinimide) to produce a significantly more stable and more soluble active intermediate (NHS ester). The intermediate can covalently conjugate to the amine group on the proteins, peptides or antibodies through displacement of sulfo-NHS group by amine. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Control Doxorubicin Liposome (PEGylated) | Control Doxorubicin Liposome (PEGylated) is a control formulation for PEGylated doxorubicin liposome. The formulation is similar to PEGylated doxorubicin liposome in size and lipid composition, but it does not contain doxorubicin drug. It is only for research purposes and for the injection to laboratory animals. The formulation is made in ammonium sulfate gradient and it is ready for injection. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Cyanur-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the cyanur group. Proteins can be covalently coupled to the liposome via amine-reactive cyanur-groups, either directly to the vesicle surface using cyanuric chloride-activated DSPE (cyanur-DSPE) or to the distal ends of PEG-spacers using activated cyanur-PEG-PE (ammonium salt). Cyanuric chloride at the PEG terminus functions to link peptides, antibodies and other amine-containing biomolecules or nanoparticles via a nucleophilic substitution reaction under basic conditions. Antibodies or other proteins can be conjugated without any previous derivatization. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| DBCO-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the dibenzocyclooctyne (DBCO) group, which can react with an azide by click chemistry. The conjugation chemistry is based on the reaction of the DBCO reagent with an azide linker to form a stable triazole. Azide moiety can be on the antibody and DBCO moiety can be on liposome and vice versa. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Folate-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the folate. Folate binding protein (FBP) is an endogenous protein, which shows a very high affinity for folate. An antibody can be tagged by FBP and an immunoliposome can be formed by non-covalent and high affinity interaction between FBP and folate lipid on the surface of the liposome. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| PDP-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the pyridyldithiopropionate (PDP) group. The liposome containing PDP lipids are used to conjugate proteins, antibodies and other molecules containing the reactive moiety. The PDP group contains disulfide, which can react with sulfhydryl or thiolated proteins/antibodies. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Succinyl-Doxorubicin Liposome (PEGylated) | This formulation is Doxorubicin Liposome (PEGylated) with the carboxyl group, which can be activated by EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide) and react with sulfo-NHS (N-hydroxysulfosuccinimide) to produce a significantly more stable and more soluble active intermediate (NHS ester). The intermediate can covalently conjugate to the amine group on the proteins, peptides or antibodies through displacement of sulfo-NHS group by amine. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Annamycin | Annamycin liposomal is a liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. Liposomal annamycin is less toxic and shows improved antitumor activity compared to annamycin. Uses: Antibiotics, antineoplastic. Synonyms: 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin; AR-522. CAS No. 92689-49-1. Molecular formula: C26H25IO11. Mole weight: 640.38. |  |
| 1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt | 1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt is used to prepare polyethyleneglycol-modified liposomal doxorubicin for therapies against drug resistant tumors. It is also used in the PEGylated liposomal drug formulation of the anti-cancer agent oxaliplatin. Group: Biochemicals. Grades: Highly Purified. CAS No. 200880-42-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C42H82NaO10P. US Biological Life Sciences. |  Worldwide |
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