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Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: α-Ecdysone. CAS No. 3604-87-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0179.
Ecdysone
Ecdysone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ecdysone; (2β,3β,5β,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one; A-ECDYSONE; α-Ecdysone; Gynostemma Gypenosides; [3H]-Ecdysone. Product Category: Steroidal Compounds. Appearance: Cryst. CAS No. 3604-87-3. Molecular formula: C27H44O6. Mole weight: 464.63. Purity: 0.98. IUPACName: (2S,3R,5R,9R,10R,13R,14S,17R)-17-[(2S,3R)-3,6-dihydroxy-6-methylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one. Canonical SMILES: CC(C1CCC2(C1(CCC3C2=CC(=O)C4C3(CC(C(C4)O)O)C)C)O)C(CCC(C)(C)O)O. Density: 1.22g/cm³. ECNumber: 222-760-4. Product ID: ACM3604873. Alfa Chemistry ISO 9001:2015 Certified.
ecdysone 20-monooxygenase
An enzyme from insect fat body or malpighian tubules involving a heme-thiolate protein (P-450). NADPH can act as ultimate hydrogen donor. Group: Enzymes. Synonyms: α-ecdysone C-20 hydroxylase; ecdysone 20-hydroxylase. Enzyme Commission Number: EC 1.14.99.22. CAS No. 55071-97-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1040; ecdysone 20-monooxygenase; EC 1.14.99.22; 55071-97-1; α-ecdysone C-20 hydroxylase; ecdysone 20-hydroxylase. Cat No: EXWM-1040.
ecdysone O-acyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. Group: Enzymes. Synonyms: acyl-CoA:ecdysone acyltransferase; fatty acyl-CoA:ecdysone acyltransferase. Enzyme Commission Number: EC 2.3.1.139. CAS No. 120038-26-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2077; ecdysone O-acyltransferase; EC 2.3.1.139; 120038-26-8; acyl-CoA:ecdysone acyltransferase; fatty acyl-CoA:ecdysone acyltransferase. Cat No: EXWM-2077.
ecdysone oxidase
2,6-Dichloroindophenol can act as an acceptor. Group: Enzymes. Synonyms: β-ecdysone oxidase. Enzyme Commission Number: EC 1.1.3.16. CAS No. 56803-12-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0398; ecdysone oxidase; EC 1.1.3.16; 56803-12-4; β-ecdysone oxidase. Cat No: EXWM-0398.
20-Hydroxyecdysone
A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. More potent than ecdysone. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Regulates lipolysis in insects. Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Used for controlled gene expression in scientific research, agriculture and medicine. Used for the development of selective insect growth regulators for use as environmentally benign insecticides. Shows biological effects on mammalian species. Neurosteroid. Antiepileptic. Acts on the modulatory site of the GABAA receptor and potentia Group: Biochemicals. Grades: Highly Purified. CAS No. 5289-74-7. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C27H44O7. US Biological Life Sciences.
Worldwide
20-Hydroxy ecdysone
20-Hydroxy ecdysone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one; 20-Hydroxyecdysone; ecdysterone; β-ecdysone; Hydroxyecdysone. Product Category: Steroidal Compounds. Appearance: CANARY YELLOW FINE POWDER. CAS No. 5289-74-7. Molecular formula: C27H44O7. Mole weight: 480.63. Purity: 0.98. IUPACName: (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one. Canonical SMILES: CC12CCC3C(=CC(=O)C4C3(CC(C(C4)O)O)C)C1(CCC2C(C)(C(CCC(C)(C)O)O)O)O. Density: 1.28 g/cm³. Product ID: ACM5289747. Alfa Chemistry ISO 9001:2015 Certified.
1,2-Dibenzoyl-1-(tert-butyl)hydrazine
1,2-Dibenzoyl-1-(tert-butyl)hydrazine is an ecdysone agonist that causes the premature initiation of molting at all stages of larval development of the tobacco hornworm, Manduca sexta. Group: Biochemicals. Grades: Highly Purified. CAS No. 112225-87-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C18H20N2O2, Molecular Weight: 296.36. US Biological Life Sciences.
Worldwide
3-Bromo-1-phenyl-1H-pyrazole-5-carboxylic Acid
3-Bromo-1-phenyl-1H-pyrazole-5-carboxylic Acid is a novel pyrazole agent used as an ecdysone analog. Exhibits good inhibition against the EcR/USP receptor similar to that of Tebufenozide (T013200) an insecticide. Group: Biochemicals. Grades: Highly Purified. CAS No. 1250084-79-7. Pack Sizes: 5mg, 10mg. Molecular Formula: C10H7BrN2O2, Molecular Weight: 267.08. US Biological Life Sciences.
Worldwide
Cyromazine
Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyromazin; CGA-72662. CAS No. 66215-27-8. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-B1331.
Cyromazine (Standard)
Cyromazine (Standard) is the analytical standard of Cyromazine. This product is intended for research and analytical applications. Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 66215-27-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B1331R.
Ecdysterone
Ecdysterone - Product ID: NST-10-106. Category: Steroids. Alternative Names: 20-Hydroxyecdysone, Commisterone, Crustecdyson, Ecdysone, Ekdisten, Isoinokosterone, Polypodin A, Sarconeos, Viticosterone. Purity: 98%. Test method: HPLC. CAS No. 5289-74-7. Pack Sizes: 5g, 10g, 25g, 50g. Appearance: White powder. Molecular formula: C27H44O7. Mole weight: 480.63. Storage: +2 +8 °C.
Methoxyfenozide
Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with K d values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua , S. frugiperda , T. ni , O. nubilalis , L. pomonella , H. zea , and H. virescens (LC 50 s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively). Uses: Scientific research. Group: Signaling pathways. CAS No. 161050-58-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-117386.
Muristerone A
Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Synonyms: (2β, 3β, 5β, 11α, 22R)-2, 3, 5, 11, 14, 20, 22-Heptahydroxycholest-7-en-6-one; Mur A. Grades: ≥97% by HPLC. CAS No. 38778-30-2. Molecular formula: C27H44O8. Mole weight: 496.63.
Muristerone A
Muristerone A is a potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. An analog of ecdysone with similar properties to Ponasterone A. Inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals.Induces apoptosis in cells transfected with wild-type Bax. Induces expression of beta-galactosidase. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Insect steroid hormone involved in regulating metamorphosis, causing a response to G2 cell cycle arrest. Major molting hormone in some insects. Has protective effects in plants.Source:Ipomoea hederacea seeds. Group: Biochemicals. Alternative Names: 2beta, 3beta, 5beta, 11alpha, 14alpha, 20R, 22R-Heptahydroxycholest-7-en-6-one. Grades: Highly Purified. CAS No. 38778-30-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C27H44O8, Method for Determining. US Biological Life Sciences.
Worldwide
Tebufenozide
Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 112410-23-8. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B2054.
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