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| Product | Description | |
|---|---|---|
| Elimusertib | Elimusertib (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC 50 of 7 nM. Elimusertib has anti-tumor activity [1] [2]. Elimusertib can be used for the research of solid tumors and lymphomas [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 1895344. CAS No. 1876467-74-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101566. |  |
| Elimusertib free base | Elimusertib, also known as BAY-1895344, is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Elimusertib, free base; BAY-1895344; BAY 1895344; BAY1895344. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1876467-74-1. Molecular formula: C20H21N7O. Mole weight: 375.44. Purity: >98%. IUPACName: (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. Canonical SMILES: CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24. Product ID: ACM1876467741. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BAY-1895344 hydrochloride | BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibited hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM). Synonyms: Elimusertib hydrochloride; BAY 1895344 hydrochloride; BAY1895344 hydrochloride; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine hydrochloride; 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine hydrochloride; Bay 1895344; 1,7-Naphthyridine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-, hydrochloride (1:1). Grades: ≥95%. Molecular formula: C20H22ClN7O. Mole weight: 411.89. |  |
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