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| Product | Description | |
|---|---|---|
| Encequidar | Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HM30181; HM30181A. CAS No. 849675-66-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13646. |  |
| Encequidar mesylate | Encequidar, also known as HM-30181, is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Encequidar showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). Encequidar is currently under clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HM30181; HM-30181; HM 30181; HM-30181 mesylate; Encequidar mesylate. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. Purity: >98%. IUPACName: N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate. Canonical SMILES: O=C(NC1=CC(OC)=C(C=C1C2=NN(N=N2)C3=CC=C(C=C3)CCN4CC5=C(CC4)C=C(C(OC)=C5)OC)OC)C6=CC(C7=C(C=CC=C7)O6)=O.OS(=O)(C)=O. Product ID: ACM849675872. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Encequidar mesylate | Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HM30181 mesylate; HM30181A mesylate. CAS No. 849675-87-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13646A. | |
| HM30181 | HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitax...the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed. Synonyms: 4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-; N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide; Encequidar; HM 30181; HM-30181. Grades: 98%. CAS No. 849675-66-7. Molecular formula: C38H36N6O7. Mole weight: 688.74. |  |
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