Endo Protease Suppliers USA
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Product | Description | |
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Aminopeptidase N Inhibitor Quick inquiry Where to buy Suppliers range | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
BV6 Quick inquiry Where to buy Suppliers range | BV-6 is a selective inhibitor of apoptosis (IAP) family with IC50 value of 7.2 μM when tested with H460 cells. It acts by promoting glioblastoma cancer stem-like cell differentiation by activating NF-κB. BV-6 induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells at 5 μM. In BALB/c mice model with transplanted abdominal cavities from donor mouse uterine tissue, intraperitoneally with BV-6 repressed the advancement of endometriosis, cell proliferative activity via inhibiting the expression of IAPs. In hematological THP-1 cells, pre-treatment with BV-6 increased the CIK cells killing ability and the same results were achieved in solid malignancy RH30 cells. Grades: ≥98%. CAS No. 1001600-56-1. Molecular formula: C70H96N10O8. Mole weight: 1205.57. | |
Cytochalasin A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Helminthosporium dematioideum, Coriolus vernicipes. It has many biological activities, such as inhibiting cytokinesis reversibly, inhibiting megasophil endocytosis and exocytosis. Cytochalasin A is an HIV protease inhibitor. Synonyms: NSC174119; Dehydrophomin; 5-Dehydrophomin; 5,5-Didehydrophomin; 2H-Oxacyclotetradecino(2,3-d)isoindole-2,5,18-trione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E, 9R, 11E, 12aS, 13S, 15S, 15aS, 16S, 18aS)-; (7S,13E,16R,21E)-7-Hydroxy-16-methyl-10-phenyl-24-Oxa[14]cytochalasa-6(12),13,21-triene-1,20,23-trione; 16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-2H-Oxacyclotetradecino[2,3-d]isoindole-2,5,18-trione. Grades: >98% by HPLC. CAS No. 14110-64-6. Molecular formula: C29H35NO5. Mole weight: 477.59. | |
Dihydroeponemycin Quick inquiry Where to buy Suppliers range | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells. Grades: ≥98%. CAS No. 126463-64-7. Molecular formula: C20H36N2O6. Mole weight: 400.5. | |
IWR-1 (IWR-1-endo) Quick inquiry Where to buy Suppliers range | Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3 β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3 β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Group: Biochemicals. Alternative Names: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide. Grades: Highly Purified. CAS No. 1127442-82-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 409.4. US Biological Life Sciences. | Worldwide |
Kendomycin Quick inquiry Where to buy Suppliers range | Kendomycin is an endothelin receptor antagonist and proteasome inhibitor. It induces apoptosis in lymphoma. It is a potent antibacterial agent against gram-positive and gram-negative bacteria, including MRSA strains. Synonyms: TAN 2162. Grades: >95% by HPLC. CAS No. 183202-73-5. Molecular formula: C29H42O6. Mole weight: 486.64. | |
Kendomycin ((-)-TAN 2162) Quick inquiry Where to buy Suppliers range | Antibiotic. Potent endothelin receptor antagonist. Anti-osteoporotic. Antibacterial. Cytotoxic. Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Group: Biochemicals. Grades: Highly Purified. CAS No. 183202-73-5. Pack Sizes: 100ug, 500ug. US Biological Life Sciences. | Worldwide |
ML241 HCl Quick inquiry Where to buy Suppliers range | ML241 is identified as a potent and selective inhibitors of p97 ATPase (IC(50)= 100 nM). ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 could impair the endoplasmic-reticulum-associated degradation (ERAD) pathway. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine hydrochloride; ML241; ML-241; ML 241; ML241 HCl; ML241 hydrochloride. CAS No. 2070015-13-1. Molecular formula: C23H25ClN4O. Mole weight: 408.93. | |
Nelfinavir Mesylate (AG-1343, AG1343, Viracept) Quick inquiry Where to buy Suppliers range | Nelfinavir is a potent competitive inhibitor of the HIV-1 protease. It is reported that it can also inhibit the growth of various cell types and trigger apoptosis. Besides being a protease inhibitor used in the therapeutic agent for acquired immunodeficiency syndrome (AIDS), it is also stimulates autophagy and and exhibits anti-cancer properties. It appears to do by inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response (1). Nelfinavir has also been shown to treat SARS-coronavirus (2), and is being tested currently to treat COVID-19. Group: Biochemicals. Alternative Names: AG-1343, AG1343, Viracept; (3S, 4aS, 8aS)-N-tert-butyl-2-[(2R, 3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3, 4, 4a, 5, 6, 7, 8, 8a-octahydro-1H-isoquinoline-3-carboxamide; methanesulfonic acid. Grades: Highly Purified. CAS No. 159989-65-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S? , Molecular Weight: 663.89. US Biological Life Sciences. | Worldwide |
Ono 3403 Quick inquiry Where to buy Suppliers range | Ono 3403, a derivative of camostat mesilate and has a higher protease-inhibitory activity, is a synthetic serine protease inhibitor that inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Synonyms: (4-carbamimidoylphenyl) 4-[(E)-3-[(2-ethoxy-2-oxoethyl)-prop-2-enylamino]-2-methyl-3-oxoprop-1-enyl]benzoate;methanesulfonic acid; ethyl N-allyl-N- (2-methyl-3- (4- (4-amidinophenoxycarbonyl) phenyl) propenoyl) aminoacetate methanesulfonate; ONO 3403; ONO-3403; ONO 3403. Grades: >98%. CAS No. 181586-07-2. Molecular formula: C2H31N3O8S. Mole weight: 545.60. | |
Parstatin (human) Quick inquiry Where to buy Suppliers range | Parstatin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activated receptor-1, with antiangiogenic properties. Parstatin (human) attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. It promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Synonyms: H-Met-Gly-Pro-Arg-Arg-Leu-Leu-Leu-Val-Ala-Ala-Cys-Phe-Ser-Leu-Cys-Gly-Pro-Leu-Leu-Ser-Ala-Arg-Thr-Arg-Ala-Arg-Arg-Pro-Glu-Ser-Lys-Ala-Thr-Asn-Ala-Thr-Leu-Asp-Pro-Arg-OH; L-methionyl-glycyl-L-prolyl-L-arginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-valyl-L-alanyl-L-alanyl-L-cysteinyl-L-phenylalanyl-L-seryl-L-leucyl-L-cysteinyl-glycyl-L-prolyl-L-leucyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-threonyl-L-arginyl-L-alanyl-L-arginyl-L-arginyl-L-prolyl-L-alpha-glutamyl-L-seryl-L-lysyl-L-alanyl-L-threonyl-L-asparagyl-L-alanyl-L-threonyl-L-leucyl-L-alpha-aspartyl-L-prolyl-L-arginine. Grades: ≥98%. CAS No. 1065755-99-8. Molecular formula: C191H330N64O53S3. Mole weight: 4467.29. | |
SJB2-043 Quick inquiry Where to buy Suppliers range | SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. It inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes and inhibited the labeling of USP1 with Ub-VS in a dose dependent manner. Synonyms: SJB2-043; SJB2043; SJB2 043. Grades: >98%. CAS No. 63388-44-3. Molecular formula: C17H9NO3. Mole weight: 275.26. | |
SNOG Quick inquiry Where to buy Suppliers range | SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). Uses: Bronchodilator agents. Synonyms: S-Nitroso-L-glutathione;S-Nitrosoglutathione; Nitrosoglutathione; Glutathione thionitrite; GNSO. Grades: ≥97%. CAS No. 57564-91-7. Molecular formula: C10H16N4O7S. Mole weight: 336.32. | |
Stachybotrylactam Quick inquiry Where to buy Suppliers range | An unusual spirodihydrobenzofuranlactam mycotoxin isolated from Stachybotrys sp. It shows immunosuppressant and weak HIV protease activity and shows diverse activity including antiviral, endothelin and pancreatic cholesterase inhibition. Synonyms: 2-deoxy F1839A; (1'R,2'R,4'aS,6'R,8'aS)-3',4',4'a,5',6',7,7',8,8',8'a-Decahydro-4,6'-dihydroxy-2',5',5',8'a-tetramethylspiro[2H-furo[2,3-e]isoindole-2,1'(2'H)-naphthalen]-6(3H)-one; [1'R-(1'α, 2'α, 4'aα, 6'α, 8'aβ)]-3', 4', 4'a, 5', 6', 7, 7', 8, 8', 8'a-Decahydro-4, 6'-dihydroxy-2', 5', 5', 8'a-tetramethyl-spiro[2H-furo[2, 3-e]isoindole-2, 1'(2'H)-naphthalen]-6(3H)-one; Spirodihydrobenzofuranlactam I. Grades: >95% by HPLC. CAS No. 163391-76-2. Molecular formula: C23H31NO4. Mole weight: 385.50. | |
Stachybotrylactam (2-deoxy Antibiotic F1839A) Quick inquiry Where to buy Suppliers range | Isolated from a Stachybotrys sp., this unusual spirodi hydrobenzofuranlactam mycotoxin shows immuno-suppressant and weak HIV protease activity. Members of this structural class show diverse activity including antiviral, endothelin and pancreatic cholesterase inhibition. Group: Biochemicals. Alternative Names: 2-deoxy Antibiotic F1839A. Grades: Highly Purified. CAS No. 163391-76-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
Suc-Ala-Ala-Ala-pNA Quick inquiry Where to buy Suppliers range | N-Succinyl-Ala-Ala-Ala-p-nitroanilide is a chromogenic substrate for chymotrypsin-like serine protease, pancreatic elastase and serine endopeptidase. Group: Biochemicals. Alternative Names: N-Succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide; N-Succinyl-tri-L-alanine 4-nitroanilide. Grades: Highly Purified. CAS No. 52299-14-6. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C19H25N5O8, Molecular Weight: 451.43. US Biological Life Sciences. | Worldwide |
Talmapimod hydrochloride Quick inquiry Where to buy Suppliers range | Talmapimod, also known as SCIO-469, is an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins. Synonyms: SCIO 469 hydrochloride; SCIO469 hydrochloride; SCIO-469 hydrochloride. Grades: >98%. CAS No. 309913-83-5. Molecular formula: C27H30ClFN4O3. Mole weight: 513.01. |