Enzyme Epimerase Suppliers USA
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Product | Description | |
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BTZ043 Quick inquiry Where to buy Suppliers range | The new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase. To monitor the potential development of benzothiazinone (BTZ) resistance, a total of 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for the presence of mutations in the dprE1 gene and for BTZ susceptibility. All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials. Synonyms: BZT043; BZT 043; BZT-043; 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one. CAS No. 1161233-85-7. Molecular formula: C17H16F3N3O5S. Mole weight: 431.39. | |
PBTZ169 Quick inquiry Where to buy Suppliers range | PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. DprE1 is an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The MIC values of PBTZ169 ranged from 0.03 μg/mL to 0.0037 μg/mL. The MIC50 value of PBTZ169 was 0.0075μg/mL; MIC90 value was 0.030 μg/mL. Uses: Anti-bacterial. Synonyms: PBTZ169; PBTZ-169; PBTZ 169; macozinone; 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one. Grades: 98%. CAS No. 1377239-83-2. Molecular formula: C20H23F3N4O3S. Mole weight: 456.48. |