Epoxomicin Suppliers USA
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Product | Description | |
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Epoxomicin Quick inquiry Where to buy Suppliers range | Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. Uses: Proteasome inhibitors. Synonyms: BU-4061T. Grades: >98%. CAS No. 134381-21-8. Molecular formula: C28H50N4O7. Mole weight: 554.72. | |
Epoxomicin Quick inquiry Where to buy Suppliers range | Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Group: Biochemicals. Alternative Names: N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide, BU 4061T. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 100ug, 250ug, 500ug. Molecular Formula: C??H??N?O?, Molecular Weight: 554.7. US Biological Life Sciences. | Worldwide |
Epoxomicin (BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1 [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide) Quick inquiry Where to buy Suppliers range | Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin. Blocks also trypsin-like and PGPH activities of the proteasome. Group: Biochemicals. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 250ug. US Biological Life Sciences. | Worldwide |
Epoxomicin, Synthetic Quick inquiry Where to buy Suppliers range | Epoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 100μG. Mole weight: 554.72. Catalog: IAR42410900. Assay: ≥95% (HPLC). | |
InSolution Epoxomicin, Synthetic Quick inquiry Where to buy Suppliers range | Epoxomicin, Synthetic, is a 1 mM solution of Epoxomicin, Synthetic (Cat. No. 324800) in DMSO. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 50μG. Mole weight: 554.72. Catalog: IAR42410901. Assay: ≥95% (HPLC). | |
[ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester Quick inquiry Where to buy Suppliers range | [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester is a reagent in the synthesis of proteasome inhibitor epoxomicin, which has antitumor, antiinflammatory and antibiotic properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 247068-83-3. Pack Sizes: 10mg, 100mg. Molecular Formula: C14H25NO4, Molecular Weight: 271.35. US Biological Life Sciences. | Worldwide |
[ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester-d3 Quick inquiry Where to buy Suppliers range | [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester-d3 is the isotope labelled analog of [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester. [ (1S) -3-Methyl-1- [ [ (2S) -2-methyloxiranyl] carbonyl] butyl] -carbamic Acid 1,1-Dimethylethyl Ester is a reagent in the synthesis of proteasome inhibitor epoxomicin, which has antitumor, antiinflammatory and antibiotic properties. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C14H22D3NO4, Molecular Weight: 274.37. US Biological Life Sciences. | Worldwide |
Carfilzomib Quick inquiry Where to buy Suppliers range | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Synonyms: Kyprolis; PR171; PR-171; PR 171; (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide. Grades: ≥98%. CAS No. 868540-17-4. Molecular formula: C40H57N5O7. Mole weight: 719.9. | |
Carfilzomib Impurity 13 hydrochloride Quick inquiry Where to buy Suppliers range | Carfilzomib is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It is a second-generation and peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome with IC50 of 5.2 nM. Carfilzomib impurity 13 hydrochloride is a potential impurity found in commercial carfilzomib preparations. Grades: ≥95%. CAS No. 2319881-95-1. Molecular formula: C16H22N2O4·HCl. Mole weight: 342.8. |