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Myristoyl-CoA, an indispensable metabolite within the fatty acid metabolic pathway, exhibits significant involvement as a substrate for diverse enzymes, serving a pivotal function in post-translational modifications. Its indispensability lies in promoting protein membrane association through protein myristoylation. Synonyms: Myristoyl-Coenzyme A; Tetradecanoyl-CoA; S-Tetradecanoyl-coenzyme A; S- [2- [3- [ [ (2R) -4- [ [ [ (2R, 3S, 4R, 5R) -5- (6-aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3, 3-dimethylbutanoyl] amino] propanoylamino] ethyl] tetradecanethioate. CAS No. 3130-72-1. Molecular formula: C35H62N7O17P3S. Mole weight: 977.89.
Squarunkin A is an inhibitor of UNC119 chaperone protein-cargo interaction. It inhibits the binding of a myristoylated peptide representing the N-terminus of Src kinase to UNC119A with an IC50 value of 10?nm. It binds to UNC119 proteins in cell lysate and interferes with the activation of Src kinase. Synonyms: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride. Grades: ≥98% by HPLC. CAS No. 2253744-55-5. Molecular formula: C25H32F3N5O4·HCl. Mole weight: 560.01.
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