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| Product | Description | |
|---|---|---|
| FAAH inhibitor 1 | Time-dependent preincubation study of FAAH inhibitor 1 was consistent with it being a reversible inhibitor. Activity-based protein-profiling (ABPP) evaluation of FAAH inhibitors 1 in rat tissues revealed that it had exceptional selectivity and no off-target activity with respect to other serine hydrolases. Molecular shape overlay of FAAH inhibitor 1 with a known FAAH inhibitor indicated that these compounds might act as transitionstate analogues, forming putative hydrogen bonds with catalytic residues and mimicking the charge distribution of the tetrahedral transition state. FAAH inhibitors 1 was exclusively specific against FAAH in rat brain and had no missing protein bands in all the other tissues that were tested. Synonyms: FAAH inhibitor 1. Grades: >98%. CAS No. 326866-17-5. Molecular formula: C24H23N3O3S3. Mole weight: 497.65. |  |
| FAAH Inhibitor II - CAS 546141-08-6 | The FAAH Inhibitor II, also referenced under CAS 546141-08-6, controls the biological activity of FAAH. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. |  |
| FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3-carbamoyl-6-hydroxybiphenyl-3-yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoyl hydroxybiphenyl-3-yl) ester) | A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| 1-Monomyristin | 1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 589-68-4. Molecular formula: C17H34O4. Mole weight: 302.45. Purity: 0.98. Canonical SMILES: CCCCCCCCCCCCCC(OCC(O)CO)=O. Product ID: ACM589684-2. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-Amino-1-(4-phenoxyphenyl)ethanol | 2-Amino-1-(4-phenoxyphenyl)ethanol is used as a reagent in the synthesis of (4-phenoxyphenyl) tetrazolecarboxamides and its related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Group: Biochemicals. Grades: Highly Purified. CAS No. 153285-74-6. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15NO2, Molecular Weight: 229.27. US Biological Life Sciences. | Worldwide |
| 2-Amino-1-[4- (trifluoromethoxy) phenyl]ethanol | 2-Amino-1-[4- (trifluoromethoxy) phenyl]ethanol is used to prepare heteroaryl derivatives such as 4-aminopyrimidine derivatives as fatty acid amide hydrolase (FAAH) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1038262-63-3. Pack Sizes: 100mg, 1g. Molecular Formula: C9H10F3NO2, Molecular Weight: 221.18. US Biological Life Sciences. | Worldwide |
| 2-Linoleoyl glycerol | 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Monolinolein; 2-Monolinoleoylglycerol. CAS No. 3443-82-1. Pack Sizes: 500 μg (14.10 mM * 100 μL in Methyl acetate); 1 mg (14.10 mM * 200 μL in Methyl acetate). Product ID: HY-130311. |  |
| 4-(n-nonyl) benzeneboronic acid | Fatty acid amide hydrolase (FAAH) is the primary enzyme responsible for the hydrolysis of the endocannabinoid arachidonoyl ethanolamide (AEA). 4-(n-nonyl) benzeneboronic acid is a potent inhibitor of FAAH, with an IC50 of 9.1 nM. Synonyms: 4-Nonylphenylboronic acid; (4-nonylphenyl)boronic acid. Grades: ≥98%. CAS No. 256383-45-6. Molecular formula: C15H25BO2. Mole weight: 248.2. | |
| AACOCF | AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro. Synonyms: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one; Arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane. CAS No. 149301-79-1. Molecular formula: C21H31F3O. Mole weight: 356.47. | |
| AM 374 | AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC 50 value of 13 nM. AM 374 can be used for the research of neurological disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 86855-26-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125967. | |
| AM404 | AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis. AEM is also an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its reuptake into presynaptic neurons. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo. Synonyms: 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-; (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (all-Z)-; AM 404; AM404. Grades: ≥98%. CAS No. 183718-77-6. Molecular formula: C26H37NO2. Mole weight: 395.58. | |
| Arachidonyl serotonin | Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor, which is responsible for inactivation of anandamide and other endogenous cannabinoids. Its IC50 values are 37-40 nM and 5.6 μM for TRPV1 and FAAH respectively. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC50 value of 12 μM. It is a very tight binding, competitive inhibitor of FAAH. It does not inhibit cPLA2 and is essentially devoid of cannabimimetic activity. It was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion. It displays strong analgesic activity against both acute and chronic peripheral pain in rodents. Synonyms: AA-5HT; AA5HT; AA 5HT; N-arachidonoyl-serotonin; Arachidonoyl serotonin; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; AA-5HT; AA5HT; N-arachidonoyl-serotonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14-tetraenamide. CAS No. 187947-37-1. Molecular formula: C30H42N2O2. Mole weight: 462.67. | |
| ARN726 | ARN726 is a systemically active and orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 value of 27 nM for human and 63 nM for rat NAAA. The selectivity for NAAA is better than fatty acid amide hydrolase (FAAH) with IC50s of 100 uM. It is also selective over acid cermidase with IC5Os of 12.5 uM. ARN726 can decrease lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. Synonyms: ARN-0726; ARN 0726. Grades: ≥95%. CAS No. 1628343-77-0. Molecular formula: C14H24N2O3. Mole weight: 268.35. | |
| Arvanil | Arvanil is a vanilloid TRPV1 (VR1) and cannabinoid CB1 agonist with Ki values of 0.3 and 0.5 μM respectively. It increases lung tidal volume, diaphragm activity, mean arterial blood pressure and inhibits lymphocyte proliferation. It also inhibits the anandamide transporter. It has analgesic, vasodilatory and anti-inflammatory effects in vivo. It is a structural analog of capsaicin. It induces analgesia in rat and mouse models of pain. It is resistant to hydrolysis by FAAH. It is a potent inhibitor of anandamide accumulation. It inhibits growth of astrocytoma xenograft tumors in mice. It mimics the effect of neural precursor cells and has been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. Synonyms: RT-011322; B-6699; I14-44667; RT011322; B6699; I1444667; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide; N-Vanillylarachidonamide; (all-Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. Grades: ≥98% by HPLC. CAS No. 128007-31-8. Molecular formula: C28H41NO3. Mole weight: 439.64. | |
| BIA 10-2474 | BIA 10-2474 is an inhibitor of fatty acid amide hydrolase ( FAAH ) with IC 50 values of 50 to 70mg/kg in various rat brain regions. Uses: Scientific research. Group: Signaling pathways. CAS No. 1233855-46-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19740. | |
| BIA10-2474 | This active molecular is a reversible FAAH (fatty acid amide hydrolase) inhibitor that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (except the brain and spinal cord) under the development of Bial-Portela & Ca. SA. BIA 10-2474 can interact with the human endocannabinoid system and was inpplicated in the treatment of a range of different medical conditions including anxiety, Parkinson's disease, chronic pain of multiple sclerosis, cancer, hypertension and obesity. Clinical trial with BIA 10-2474 was on-going. However, severe adverse events occurred in January 2016 affecting 5 patients, including leading to the death of one. Uses: Neurological disorders; pain; psychiatric disorders. Synonyms: BIA 10-2474; BIA-10-2474; BIA10-2474; N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide;UNII-5AP1ZW859M; SCHEMBL427970; 5AP1ZW859M; GTPL9001; DOWVMJFBDGWVML-UHFFFAOYSA-N. Grades: 98%. CAS No. 1233855-46-3. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
| Biochanin A | Biochanin A is a naturally occurring fatty acid amide hydrolase ( FAAH ) inhibitor, which inhibits FAAH with IC 50 s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: 4-Methylgenistein; Olmelin. CAS No. 491-80-5. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-14595. | |
| Cancer Hydrolase KIAA1363 Inhibitor, JW480 (2-Isopropylphenyl-2- (2-naphthyl) ethylcarbamate, AADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor) | A membrane-permeable, highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50=12nM; PC3 lysate) and murine (IC50=20nM; brain membrane samples) origin, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice and effectively suppresses PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80mg/kg/day; o.g.). Also inhibits blood carboxylesterase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Carmofur | Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC 50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease ( Mpro ), fatty acid amide hydrolase ( FAAH ) and N-acylethanolamine acid amidase ( NAAA ). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HCFU. CAS No. 61422-45-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0182. | |
| Carprofen | Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC 50 s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively. Uses: Scientific research. Group: Natural products. CAS No. 53716-49-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1227. | |
| CAY10401 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. It is approximately 580-fold more potent than oleyl trifluoromethyl ketone. Synonyms: CAY 10401; CAY-10401; 1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one. Grades: ≥98%. CAS No. 288862-89-5. Molecular formula: C24H34N2O2. Mole weight: 382.5. | |
| CAY10435 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH with Ki value of 0.57 nM. It exhibited IC50 values of 0.81 nM, 83 nM, and 50 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Synonyms: CAY 10435; CAY-10435. Grades: ≥98%. CAS No. 288862-73-7. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| CAY10499 | Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively). Synonyms: CAY-10499; CAY 10499; Magl-IN-5. Grades: ≥98%. CAS No. 359714-55-9. Molecular formula: C18H17N3O5. Mole weight: 355.34. | |
| CAY10570 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC50 value of 1.3 μM. It has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed. Synonyms: CAY 10570; CAY-10570. Grades: >98%. CAS No. 875014-22-5. Molecular formula: C25H32N2OS. Mole weight: 408.6. | |
| IDFP | IDFP is an organophosphorus compound that acts as an irreversible inhibitor of MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. Inhibition of MAGL and FAAH increases anandamide and 2-AG in the brain, resulting in increased cannabinoid signaling and typical cannabinoid behavioral effects in animal studies. Synonyms: Isopropyl Dodecylfluorophosphonate; 1-[fluoro(propan-2-yloxy)phosphoryl]dodecane. Grades: ≥98%. CAS No. 615250-02-7. Molecular formula: C15H32FO2P. Mole weight: 294.4. | |
| JNJ-1661010 | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. Synonyms: Takeda-25; N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; JNJ 1661010; JNJ1661010; N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. Grades: ≥98%. CAS No. 681136-29-8. Molecular formula: C19H19N5OS. Mole weight: 365.45. | |
| JNJ-40355003 | JNJ-40355003 is a selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 can elevate the plasma levels of anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide in animal model. Synonyms: JNJ-40355003; JNJ 40355003; JNJ40355003; 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-1-Piperazinecarboxamide. Grades: 98%. CAS No. 1394894-41-7. Molecular formula: C23H23ClN4O2. Mole weight: 422.91. | |
| JNJ-42165279 | JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going. Uses: Anxiety disorders and major depressive disorder. Synonyms: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279. Grades: 98%. CAS No. 1346528-50-4. Molecular formula: C18H17ClF2N4O3. Mole weight: 410.81. | |
| JNJ-42165279 | JNJ-42165279 is an orally active FAAH inhibitor, with IC 50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-50-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19636. | |
| JNJ-42165279 hydrochloride | JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. Synonyms: JNJ-42165279 hydrochloride; JNJ 42165279 hydrochloride; JNJ42165279 hydrochloride; 1-Piperazinecarboxamid?e, N-(4-chloro-3-pyridinyl)?-4-[(2,?2-difluoro-1,?3-benzodioxol-5-yl)?methyl]?-, hydrochloride (1:1). CAS No. 1346528-52-6. Molecular formula: C18H17ClF2N4O3. HCl. Mole weight: 447.3. | |
| JP104 | JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. JP104 is in the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-undecynecarbamate. Grades: ≥98%. CAS No. 887264-45-1. Molecular formula: C25H30N2O3. Mole weight: 406.5. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor. JP83 is in the carbamate class with an IC50 of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-hexylphenylcarbamate. Grades: ≥98%. CAS No. 887264-44-0. Molecular formula: C26H28N2O3. Mole weight: 416.5. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC 50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 887264-44-0. Pack Sizes: 1 mg. Product ID: HY-111199. | |
| JZL195 | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
| JZL195 | JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC 50 s of 2 and 4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210004-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15250. | |
| KT109 | KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540. | |
| Macamide B | Macamide B (N-Benzylhexadecanamide; Macamide 1) is a macamide isolated from Lepidium meyenii , acts as an inhibitor of fatty acid amide hydrolase (FAAH). Uses: Scientific research. Group: Natural products. Alternative Names: N-Benzylpalmitamide; N-Benzylhexadecanamide; Macamide 1. CAS No. 74058-71-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2365. | |
| Methyl α-Linolenyl Fluorophosphonate | Methyl α-linolenyl fluorophosphonate (MLnFP) is an analog of methyl arachidonyl fluorophosphonate (MAFP), an inhibitor of PLA2, FAAH and CB1 receptor. Synonyms: MαLnFP; Methyl alpha-Linolenyl Fluorophosphonate; (3Z,6Z,9Z)-18-[fluoro(methoxy)phosphoryl]octadeca-3,6,9-triene. Grades: ≥98%. Molecular formula: C19H34FO2P. Mole weight: 344.4. | |
| Methyl Arachidonyl Fluorophosphonate | Methyl arachidonyl fluorophosphonate (MAFP) is a selective and irreversible inhibitor of PLA2 and FAAH. It also binds to CB1 receptor in rat brain membrane preparations. Uses: Enzyme inhibitors. Synonyms: MAFP; (5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene. Grades: ≥98%. CAS No. 188404-10-6. Molecular formula: C21H36FO2P. Mole weight: 370.5. | |
| Methyl γ-Linolenyl Fluorophosphonate | Methyl γ-Linolenyl Fluorophosphonate (MLnFP) is an analog of methyl arachidonyl fluorophosphonate (MAFP), an inhibitor of PLA2, FAAH and CB1 receptor. Synonyms: MγLnFP; Methyl gamma-Linolenyl Fluorophosphonate; (6Z,9Z,12Z)-1-[fluoro(methoxy)phosphoryl]octadeca-6,9,12-triene. Grades: ≥98%. CAS No. 1370451-91-4. Molecular formula: C19H34FO2P. Mole weight: 344.4. | |
| N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate | N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate acts as an inhibitor of fatty acid amide hydrolase (FAAH). It decreased cell viability of non-small lung cancer cells A549 and H460 with IC50 of 4.9 and 0.9 μM, respectively. Synonyms: Pyridin-3-ylmethyl N-[(Z)-heptadec-8-enyl]carbamate. Grades: ≥98%. CAS No. 1450603-63-0. Molecular formula: C24H40N2O2. Mole weight: 388.6. | |
| N-Arachidonoylserotonin | N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC 50 value of 1~12 μM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC 50 =70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl serotonin; AA-5-HT. CAS No. 187947-37-1. Pack Sizes: 5 mg (108.07 mM * 0.1 mL in methyl acetate); 10 mg (108.07 mM * 0.2 mL in methyl acetate); 25 mg (108.07 mM * 0.5 mL in methyl acetate); 50 mg (108.07 mM * 1 mL in methyl acetate). Product ID: HY-103337. | |
| N-Boc-N-methylpiperazine | Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors. Group: Biochemicals. Alternative Names: 4-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-Methyl-4- (tert-butoxycarbonyl) piperazine; 4-Methylpiperazine-1-carboxylic Acid tert-Butyl Ester. Grades: Highly Purified. CAS No. 53788-49-1. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| O-2093 | O-2093 is an inhibitor of anandamide uptake with IC50 of 17.3 μM. It shows little or no activity at CB1, CB2, TRPV1 and FAAH. Its intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis. Synonyms: O-2093; O 2093; O2093; N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N,N-Bis[(3-chloro-4-hydroxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. CAS No. 439080-01-0. Molecular formula: C34H43Cl2NO3. Mole weight: 584.62. | |
| OL135 | OL135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. It exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. It increases the analgesic and hypothermic activity of anandamide. Uses: Ol135 is used as an analgesic drug. Synonyms: OL-135;1-Oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-phenylheptane;7-Phenyl-1-[5-(2-pyridinyl)-2-oxazolyl]-1-heptanone;7-Phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one. Grades: 98%. CAS No. 681135-77-3. Molecular formula: C21H22N2O2. Mole weight: 334.42. | |
| Oleoyl ethyl amide | Oleoyl ethyl amide is a fatty acid amide hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity. It altered sensory urodynamic parameters and reduced bladder overactivity in female rats. Synonyms: OEtA; N-Ethyloleamide; (1Z)-N-Ethyloctadec-9-enimidate. Grades: ≥98%. CAS No. 85075-82-7. Molecular formula: C20H39NO. Mole weight: 309.5. | |
| Oleoyl oxazolopyridine | Oleoyl oxazolopyridine is a potent inhibitor of fatty acid amide hydrolase (FAAH) with Ki values of 1.3 and 2.3 nM for the human and rat enzymes, respectively. It is approximately 35-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. Synonyms: CAY10400; (Z)-1-([1,3]oxazolo[4,5-b]pyridin-2-yl)octadec-9-en-1-one. Grades: ≥98%. CAS No. 288862-58-8. Molecular formula: C24H36N2O2. Mole weight: 384.6. | |
| Oleyl trifluoromethyl ketone | Oleyl trifluoromethyl ketone is a potent inhibitor of FAAH, in both human and rat. Synonyms: Heptadecyl trifluoromethyl ketone; OTK; (Z)-1,1,1-Trifluoro-nonadec-10-en-2-one. Grades: ≥98%. CAS No. 177987-23-4. Molecular formula: C19H33F3O. Mole weight: 334.5. | |
| Palmitoylisopropylamide | Palmitoyl-N-isopropylamide, a synthetic analog of palmitoyl ethanolamide, is an inhibitor of the FAAH (fatty acid amide hydrolase); pIC50=4.89 for inhibition of [3H]-anandamide metabolism. It displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Synonyms: N-(1-Methylethyl)-hexadecanamide; PIA. CAS No. 189939-61-5. Molecular formula: C19H39NO. Mole weight: 297.52. | |
| PF-04457845 | PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. Synonyms: PF-04457845; PF 04457845; PF04457845; PF-4457845; PF 4457845; PF4457845. Grades: >98%. CAS No. 1020315-31-4. Molecular formula: C23H20F3N5O2. Mole weight: 455.43. | |
| PF 3845 | PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3845 | PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Synonyms: PF3845; PF-3845; PF 3845. Grades: 0.98. CAS No. 1196109-52-0. Molecular formula: C24H23F3N4O2. Mole weight: 456.469. | |
| PF-3845 | PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH) , with a K i of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196109-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14380. | |
| PF-622 | PF-622 is an irreversible FAAH inhibitor with selectivity for FAAH relative to other serine hydrolases. Synonyms: N-Phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide. Grades: >98%. CAS No. 898235-65-9. Molecular formula: C21H22N4O. Mole weight: 346.4. | |
| PF 750 | Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system. Group: Biochemicals. Alternative Names: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide; N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide. Grades: Highly Purified. CAS No. 959151-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF 750 | PF 750 is a potent, time-dependent, irreversible FAAH inhibitor (IC50 = 16.2 nM) that exhibits no activity at a range of other serine hydrolases. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. Synonyms: PF-750; PF 750; PF750. N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 959151-50-9. Molecular formula: C22H23N3O. Mole weight: 345.44. | |
| PHOP | PHOP is a potent FAAH inhibitor with Ki values of 0.094 nM and 0.2 nM for the human and rat enzymes, respectively. Synonyms: CAY10402; Phenyl hexanoyl oxazolopyridine; 1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one. Grades: ≥98%. CAS No. 288862-83-9. Molecular formula: C18H18N2O2. Mole weight: 294.4. | |
| SA 47 | SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. Synonyms: SA-47; SA 47; SA47; N-[2-[1-(6-Methyl-2-pyridinyl)-4-piperidinyl]ethyl]carbamic acid 2-(methylamino)-2-oxoethyl ester; [2-(methylamino)-2-oxoethyl] N-[2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate. Grades: ≥99% by HPLC. CAS No. 792236-07-8. Molecular formula: C17H26N4O3. Mole weight: 334.41. | |
| SA 57 | SA 57 is a potent fatty acid amide hydrolase (FAAH) inhibitor (IC50 <10 nM), and also inhibits MAGL at higher concentrations (IC50 = 410 nM and 1.4 μM, respectively). Synonyms: SA 57; SA57; SA-57; 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester; [2-(methylamino)-2-oxoethyl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate. Grades: ≥99% by HPLC. CAS No. 1346169-63-8. Molecular formula: C17H23ClN2O3. Mole weight: 338.83. | |
| Stearda | Stearda is an endogenous fatty acid dopamide that is inactive at TRPV1 and CB1 receptors at concentrations up to 5 μM and exhibits no inhibitory effects on AMT or FAAH (IC50 > 25 μM). However, stearda potentiates TRPV1-mediated effects of NADA in vitro and in vivo, and enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. It also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM). Synonyms: N-(3,4-dihydroxyphenethyl)stearamide; N-stearoyl-dopamine. Grades: ≥98% by HPLC. CAS No. 105955-10-0. Molecular formula: C26H45NO3. Mole weight: 419.64. | |
| TAK 21d | TAK 21d is a potent and brain penetrating FAAH inhibitor (IC50 = 0.28 and 0.72 nM at rat and human FAAH, respectively). TAK 21d exhibits analgesic effects in vivo models of neuropathic and inflammatory pain. Synonyms: TAK-21d; TAK 21d; TAK21d; TAK-21-d; 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1143578-94-2. Molecular formula: C19H17F2N7O. Mole weight: 397.38. | |
| TC-F 2 | TC-F 2 is a potent, reversible and noncovalent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 28 and 100 nM for human and rat FAAH, respectively). Synonyms: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥99% by HPLC. CAS No. 1304778-15-1. Molecular formula: C26H25N5O2. Mole weight: 439.51. | |
| UCM 707 | UCM 707 is a potent endocannabinoid transport inhibitor (IC50 = 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH, respectively). UCM 707 potentiates hypokinetic and antinociceptive effects of anandamide in vivo. Synonyms: UCM 707; UCM707; UCM-707; (5Z,8Z,11Z,14Z)-N-(3-Furanylmethyl)-5,8,11,14-eicosatetraenamide; N-(furan-3-ylmethyl)icosa-5,8,11,14-tetraenamide. CAS No. 390824-20-1. Molecular formula: C25H37NO2. Mole weight: 383.57. | |
| URB597 | URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1. Synonyms: URB597, URB-597, URB 597, KDS-4103, KDS4103, KDS 4103. Grades: >98%. CAS No. 546141-08-6. Molecular formula: C20H22N2O3. Mole weight: 338.4. | |
| URB-597 | URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC 50 s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KDS-4103. CAS No. 546141-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10864. | |
| URB602 | URB602, a cell-permeable N-biphenyl carbamate compound, is a selective inhibitor of monoglycerol lipase (MGL). The IC50 = 28 μM and Km = 20 μM. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 μM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2. Synonyms: cyclohexyl [1,1'-biphenyl]-3-ylcarbamate; URB602; URB-602; URB 602. CAS No. 565460-15-3. Molecular formula: C19H21NO2. Mole weight: 295.38. | |
| URB602 (Biphenyl-3-yl Carbamic Acid, Cyclohexyl Ester) | URB602 is a selective inhibitor of MGL, exhibiting an IC50 of 28 µM for the rat brain enzyme. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations. Group: Biochemicals. Alternative Names: Biphenyl-3-yl Carbamic Acid, Cyclohexyl Ester. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| URB937 | URB937 is a potent, peripheral fatty acid amide hydrolase (FAAH) inhibitor with IC50 value of 26.8 nM. It was shown to reduce prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats. Synonyms: URB-937; URB 937; [3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate. Grades: ≥95%. CAS No. 1357160-72-5. Molecular formula: C20H22N2O4. Mole weight: 354.4. | |
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