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| Product | Description | |
|---|---|---|
| FAK Inhibitor 14 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| FAK Inhibitor 14 | FAK Inhibitor 14. Group: Biochemicals. Grades: Purified. CAS No. 4506-66-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| GSK-2256098 hydrochloride | GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416771-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100498A. |  |
| MNS | MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC 50 of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC 50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells [1] [2] [3] [4] [5] [6] [7] [8] [9]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 170724; 5-(2-Nitrovinyl)benzodioxole. CAS No. 1485-00-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-78263. | |
| PF-562271 | Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences. | Worldwide |
| PRT062607 Hydrochloride | PRT062607 is a highly selective and orally available Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than other kinases including Fgr, Lyn, FAK, Pyk2 and Zap70. Synonyms: PRT062607 HCl; P505-15 HCl; P505-15 hydrochloride; BIIB057 HCl; BIIB057 hydrochloride; 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, hydrochloride (1:x); 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride. Grades: ≥95%. CAS No. 1439908-97-0. Molecular formula: C19H23N9O.xHCl. Mole weight: 393.45 (free base). |  |
| Y15 | Y15 is a novel small molecule FAK phosphorylation inhibitor. It is a direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397. Besides, it promotes cell detachment and inhibits cell adhesion of cells in culture. It has been used to demonstrate a role for FAK in the regulation of aortic stiffness. Synonyms: 1,2,4,5-benzenetetramine tetrahydrochloride; Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15 FAK Inhibitor 14. Grades: >98%. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01. | |
| Y15 hydrochloride | Y15 hydrochloride, also known as FAK Inhibitor 14, is a direct FAK autophosphorylation inhibitor, blocking phosphorylation of Y397 with an IC50 value of about 1 μM. Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Y15 was shown to decrease cancer growth in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15. FAK Inhibitor 14. Product Category: Inhibitors. Appearance: Light green to green solid powder. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01. Purity: >97%. IUPACName: 1,2,4,5-benzenetetramine tetrahydrochloride. Canonical SMILES: NC1=CC(N)=C(N)C=C1N.[H]Cl.[H]Cl.[H]Cl.[H]Cl. Product ID: ACM4506665. Alfa Chemistry ISO 9001:2015 Certified. |  |
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