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| Product | Description | |
|---|---|---|
| FAK Inhibitor 14 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| FAK Inhibitor 14 | FAK Inhibitor 14. Group: Biochemicals. Grades: Purified. CAS No. 4506-66-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Alvespimycin | Alvespimycin (17-DMAG; KOS-1022; NSC 707545) is a potent, water-soluble Hsp90 inhibitor with IC50 of 62 nM. 17-DMAG displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM. In SKBR3 and SKOV3 cells which overexpress Hsp90 client protein Her2, 17-DMAG causes down-regulation of Her2 with EC50 of 8 nM and 46 nM, respectively, as well as induction of Hsp70 with EC50 of 4 nM and 14 nM, respectively, leading to significant cytotoxicity with GI50 of 29 nM and 32 nM, respectively, consistent with Hsp90 inhibition. In combination with vorinostat, 17-DMAG synergistically induces apoptosis of the cultured MCL cells as well as primary MCL cells, more potently than either agent alone, by markedly attenuating the levels of cyclin D1 and CDK4, as well as of c-Myc, c-RAF and Akt. 17-DMAG treatment at 5 mg/kg or 25 mg/kg three times per week significantly reduces tumor growth of TMK-1 xenografts, by reducing vessel area and numbers of proliferating tumor cells in sections. Consistent the inhibition of FAK signaling in vivo, 17-DMAG treatment at 25 mg/kg three times a week significantly suppresses tumor growth, and metastasis of ME180 and SiHa xenografts in mice. Administration of 17-DMAG at 10 mg/kg for 16 days significantly decreases the white blood cell count and prolongs the survival in a TCL1-SCID transplant mouse model. Uses: Hsp-90 inhibitor; potential anti-cancer drug. Synonyms: 17-DMAG; KOS 1022; K |  |
| FAK inhibitor 5 | FAK inhibitor 5 is a novel inhibitor of allosteric FAK, with IC50 values in the low micromolar range. Synonyms: 1-Ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide; Pyrazolo[4,3-c][2,1]benzothiazine, 1-ethyl-8-(4-ethylphenyl)-1,5-dihydro-5-methyl-, 4,4-dioxide. Grade: ≥95%. CAS No. 1426683-30-8. Molecular formula: C20H21N3O2S. Mole weight: 367.46. | |
| GSK-2256098 hydrochloride | GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416771-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100498A. |  |
| MNS | MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC 50 of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC 50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells [1] [2] [3] [4] [5] [6] [7] [8] [9]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 170724; 5-(2-Nitrovinyl)benzodioxole. CAS No. 1485-00-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-78263. | |
| NVP-TAE 226 | NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAE226. CAS No. 761437-28-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13203. | |
| PF-562271 | Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences. | Worldwide |
| Y15 | Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FAK Inhibitor 14. CAS No. 4506-66-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12444. | |
| Y15 hydrochloride | Y15 hydrochloride, also known as FAK Inhibitor 14, is a direct FAK autophosphorylation inhibitor, blocking phosphorylation of Y397 with an IC50 value of about 1 μM. Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Y15 was shown to decrease cancer growth in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Y15 hydrochloride; Y15 tetrahydrochloride; Y 15; Y-15. FAK Inhibitor 14. Product Category: Inhibitors. Appearance: Light green to green solid powder. CAS No. 4506-66-5. Molecular formula: C6H14Cl4N4. Mole weight: 284.01. Purity: >97%. IUPACName: 1,2,4,5-benzenetetramine tetrahydrochloride. Canonical SMILES: NC1=CC(N)=C(N)C=C1N.[H]Cl.[H]Cl.[H]Cl.[H]Cl. Product ID: ACM4506665. Alfa Chemistry ISO 9001:2015 Certified. |  |
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