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| Product | Description | |
|---|---|---|
| Fasudil | Fasudil is a potent and selective Rho-kinase (ROCK) inhibitor and vasodilator. ROCK is an enzyme that participates in vasoconstriction and vascular remodeling. Fasudil is used for the treatment of cerebral vasospasm and has the potential to treat pulmonary hypertension as well as certain memory loss. Uses: Protein kinase inhibitors. Synonyms: Fasudil; AT 877; AT-877; AT877; HA 1077; HA-1077; HA1077; 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline. Grades: >98%. CAS No. 103745-39-7. Molecular formula: C14H17N3O2S. Mole weight: 291.369. |  |
| Fasudil | Fasudil. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-((1,4-diazepan-1-yl)sulfonyl)isoquinoline. CAS No. 103745-39-7. Molecular formula: C14H17N3O2S. Mole weight: 291.37. Catalog: APB103745397. |  |
| Fasudil dihydrochloride | Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca2+ channel antagonist and vasodilator. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 203911-27-7. Molecular formula: C14H17N3O2S.2ClH. Mole weight: 364.29. Product ID: ACM203911277. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Fasudil Dimer | A dimer impurity of Fasudil. Fasudil is Ccyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor. Synonyms: 5,?5'-[(tetrahydro-1H-1,?4-diazepine-1,?4(5H)?-diyl)?bis(sulfonyl)?]?bis- Isoquinoline. Grades: > 95%. CAS No. 1337967-93-7. Molecular formula: C23H22N4O4S2. Mole weight: 482.58. | |
| Fasudil Dimer | Fasudil Dimer. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1,4-bis(isoquinolin-5-ylsulfonyl)-1,4-diazepane. CAS No. 1337967-93-7. Molecular formula: C23H22N4O4S2. Mole weight: 482.58. Catalog: APB1337967937. | |
| Fasudil hydrochloride | Fasudil HCl, a 5-isoquinolinesulfonamide derivative, is a highly selective Rho-associated protein kinase inhibitor that might have a rate in romoting the recovery of neurological function, reducing clinical symptoms and the morbidity. Uses: Fasudil hcl, a 5-isoquinolinesulfonamide derivative, is a highly selective rho-associated protein kinase inhibitor that might have a rate in romoting the recovery of neurological function, reducing clinical symptoms and the morbidity. Synonyms: Fasudil HCl; Eril; Fasudil (Hydrochloride); Fasudil Monohydrochloride; AT-877; HA-1077; AT 877; HA 1077; AT877; HA1077. Grades: >98%. CAS No. 105628-07-7. Molecular formula: C14H18ClN3O2S. Mole weight: 327.83. | |
| Fasudil Hydrochloride | 5-(1,4-Diazepane-1-sulfonyl)isoquinoline;Eril. anti-ulcer, gastrointestinal-emptying agent enhances motility in the upper gastrointestinal tract. Grades: CP. CAS No. 105628-07-7. Product ID: 8-04677. Molecular formula: C14H17N3O2S.HCl. Mole weight: 327.84. Purity: 0.99. Reference: J. Pharmacol. Sci, 108, 301, 2008. |  |
| Fasudil Hydrochloride | Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K i of 0.33 μM for ROCK1 , IC 50 s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA , PKC , PKG , respectively. Fasudil Hydrochloride is also a potent Ca 2+ channel antagonist and vasodilator [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HA-1077 Hydrochloride; AT-877 Hydrochloride. CAS No. 105628-07-7. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-10341. |  |
| Fasudil Impurity 1 | An impurity of Fasudil. Fasudil is Ccyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor. Synonyms: 8-[(hexahydro-1H-1,?4-diazepin-1-yl)?sulfonyl]?- Quinoline. Grades: > 95%. CAS No. 1423155-03-6. Molecular formula: C14H17N3O2S. Mole weight: 291.37. | |
| Fasudil Impurity 14 | Fasudil Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline 2-oxide. CAS No. 186544-56-9. Molecular formula: C14H17N3O3S. Mole weight: 307.37. Catalog: APB186544569. | |
| Fasudil Impurity 2 | An impurity of Fasudil. Fasudil is Ccyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor. Synonyms: Isoquinoline-8-sulfonic acid. Grades: > 95%. Molecular formula: C9H7NO3S. Mole weight: 209.23. | |
| Fasudil Impurity 3 | An impurity of Fasudil. Fasudil is Ccyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor. Synonyms: Isoquinoline, 8-[(hexahydro-1H-1,?4-diazepin-1-yl)?sulfonyl]?-, hydrochloride. Grades: > 95%. CAS No. 166895-80-3. Molecular formula: C14H17N3O2S. HCl. Mole weight: 291.37 36.46. | |
| Fasudil N-Hydroxy Impurity | An impurity of Fasudil. Fasudil is Ccyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor. Synonyms: 5-[(hexahydro-4-hydroxy-1H-1,?4-diazepin-1-yl)?sulfonyl]?- Isoquinoline. Grades: > 95%. CAS No. 1350827-92-7. Molecular formula: C14H17N3O3S. Mole weight: 307.37. | |
| Fasudil Pyridine N-Oxide | An impurity of Fasudil. Fasudil is Ccyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor. Synonyms: Isoquinoline, 5-[(hexahydro-1H-1,?4-diazepin-1-yl)?sulfonyl]?-, 2-oxide. Grades: > 95%. CAS No. 186544-56-9. Molecular formula: C14H17N3O3S. Mole weight: 307.37. | |
| HA1077 (Fasudil Dihydrochloride) | A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences. |  Worldwide |
| Hydroxyfasudil | Hydroxyfasudil, formed through the metabolism action of Fasudil, could be useful in improving the symptoms of pulmonary hypertension for playing the role as an active Rho-kinase inhibitor and vasodilator. IC50: 0.12 uM and 0.17 uM for ROCK1 and ROCK2, res. Uses: Hydroxyfasudil could be useful in improving the symptoms of pulmonary hypertension for playing the role as an active rho-kinase inhibitor and vasodilator. Synonyms: 5-(1,4-Diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine;Hydroxyfasudil. Grades: >99 %. CAS No. 105628-72-6. Molecular formula: C14H17N3O3S. Mole weight: 307.37. | |
| Hydroxyfasudil Hydrochloride | Hydroxyfasudil Hydrochloride, an active metabolite of Fasudil, preferentially inhibits Rho-kinase and plays a central role in the pathogenesis of coronary artery spasm. It is reported to inhibit neutrophil migration and exhibit potent vasodilatory effects in vivo. Synonyms: HA 1100 hydrochloride; HA1100 hydrochloride; HA-1100 hydrochloride; 5-(1,4-diazepan-1-ylsulfonyl)-2~{H}-isoquinolin-1-one hydrochloride; 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride. Grades: >98%. CAS No. 155558-32-0. Molecular formula: C14H18ClN3O3S. Mole weight: 343.826. | |
| Hydroxy Fasudil Hydrochloride | A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo. Group: Biochemicals. Alternative Names: 1- (1-Hydroxy-5-isoquinolinesulfonyl) homopiperazine Hydrochloride; 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone; HA1100 Hydrochloride. Grades: Highly Purified. CAS No. 155558-32-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HA-1077 dihydrochloride | HA-1077 is a potent and selective inhibitor of Rho kinase (ROCK). HA-1077 exhibited neuroprotective effects and enhanced cognition in mouse models of amyotrophic lateral sclerosis (ALS), suggesting its potential use for cognitive disorders such as ALS, Alzheimer's disease and spinal muscular atrophy. It also suppresses tumor cell motility and metastasis. Synonyms: Fasudil dihydrochloride; 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride. Grades: ≥98%. CAS No. 203911-27-7. Molecular formula: C14H17N3O2S·2HCl. Mole weight: 364.3. | |
| RKI-1447 | RKI-1447 is a potent Rho-associated kinase (ROCK) inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. In combination with fasudil, it was shown to induce differentiation of mESCs and hESCs to endoderm via ROCK inhibition. Synonyms: RKI 1447; 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea. Grades: >98%. CAS No. 1342278-01-6. Molecular formula: C16H14N4O2S. Mole weight: 326.374. | |
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