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| Product | Description | |
|---|---|---|
| Fedratinib | Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC 50 s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TG-101348; SAR 302503. CAS No. 936091-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-10409. |  |
| Fedratinib hydrochloride hydrate | Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC 50 s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TG-101348 hydrochloride hydrate; SAR 302503 hydrochloride hydrate. CAS No. 1374744-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-10409A. | |
| TG101348 | Fedratinib is a potent and selective JAK2 inhibitor with IC50 value of 6 nM. It also exhibits inhibitory effects against FLT3 (IC50 = 25 nM), RET (IC50 = 17 nM) and JAK3 (IC50 = 169 nM). Synonyms: TG101348; TG 101348; TG-101348; SAR302503; SAR-302503; SAR 302503; Fedratinib; N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide. Grades: >98%. CAS No. 936091-26-8. Molecular formula: C27H36N6O3S. Mole weight: 524.68. |  |
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