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| Product | Description | |
|---|---|---|
| Fenobam | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Fenobam | Fenobam. Group: Biochemicals. Grades: Purified. CAS No. 57653-26-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Fenobam | Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. It displays inverse agonist properties. It blocks mGluR5 constitutive activity in vitro with IC50 value of 87 nM. It has been used as a lead compound for the development of a range of newer mGluR5 antagonists. It has also shown promising initial results in the treatment of fragile X syndrome. It also displays anxiolytic activity. It was developed by Johnson & Johnson and in clinic phase 2 trials with no progress. Uses: Fenobam has been used as a lead compound for the development of a range of newer mglur5 antagonists. it has also shown promising initial results in the treatment of fragile x syndrome. it also displays anxiolytic activity. Synonyms: 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea; Fenobam; NPL-2009; NPL2009; NPL 2009. Grades: >99 %. CAS No. 57653-26-6. Molecular formula: C11H11ClN4O2. Mole weight: 266.68. |  |
| Fenobam | Fenobam is a selective and orally active mGluR5 antagonist ( IC 50 =84 nM) that can penetrate the blood-brain barrier. Fenobam shows the K d values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 57653-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101478. |  |
| Fenobam (N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea) | A potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87nM; Kd = 54nM and 31nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 57653-26-6. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O?, Primary Target: mGlu5 receptors. US Biological Life Sciences. | Worldwide |
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