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| Product | Description | |
|---|---|---|
| Ferrostatin-1 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Ferrostatin-1 | Cell-permeable. A potent ferroptosis (an iron-dependent form of non-apoptotic cell death) inhibitor. Inhibits erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60nm. Ferrostatin-1 inhibits ferroptosis in cancer cells as well as blocks glutamate-induced cell death in organotypic rat brain slices. Group: Biochemicals. Alternative Names: Fer-1, Ethyl 3-amino-4- (cyclohexylamino) benzoate. Grades: Highly Purified. CAS No. 347174-05-4. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Ferrostatin-1 | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Synonyms: Fer-1; Fer 1; Fer1; Ferrostatin-1; Ferrostatin 1; Ferrostatin1. Grades: >98%. CAS No. 347174-05-4. Molecular formula: C15H22N2O2. Mole weight: 262.35. |  |
| Ferrostatin-1 (Ferrostatin1, Ethyl-3-amino-4- (cyclohexylamino) benzoate) | A cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5mM; 3h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus; [Fer-1] = 2uM, added 0.5h prior to Glutamate) and Erastin- (50uM; 24h) induced HT-1080 death (EC50 = 60nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5uM in 10uM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- induced necrosis, STS-induced apoptosis, or Iron-independent oxidative death by Rotenone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| ZZW-115 | ZZW-115 is a potent NUPR1 inhibitor. ZZW-115 induces ferroptosis in a mitochondria-dependent manner. ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents. In addition, ZZW-115-treatment increases the accumulation of hydroperoxided lipids in these cells. ZZW-115-induced mitochondrial morphological changes, compatible with the ferroptotic process, as well as mitochondrial network disorganization and strong mitochondrial metabolic dysfunction, which are rescued by both Fer-1 and N-acetylcysteine (NAC). Of note, the expression of TFAM, a key regulator of mitochondrial biogenesis, is downregulated by ZZW-115. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ZZW-115; ZZW 115; ZZW115. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 801991-87-7. Molecular formula: C24H31F3N4S. Mole weight: 464.6. Purity: >98%. IUPACName: N,N-dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine. Canonical SMILES: FC(C(C=C1N2CCCN3CCN(CCN(C)C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F. Product ID: ACM801991877. Alfa Chemistry ISO 9001:2015 Certified. |  |
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