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| Product | Description | |
|---|---|---|
| Filanesib | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grade: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. |  |
| Filanesib | Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein ( KSP ) inhibitor, with an IC 50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-520. CAS No. 885060-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15187. |  |
| Filanesib TFA | Filanesib TFA is a selective inhibitor of kinesin spindle protein (KSP) (IC50 = 6 nM for human KSP), with potent anti-proliferative activity. It induces cell death by apoptosis in vitro. Synonyms: ARRY-520 TFA; (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate; Acetic acid, 2,2,2-trifluoro-, compd. with (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (1:1). CAS No. 1781834-99-8. Molecular formula: C22H23F5N4O4S. Mole weight: 534.50. | |
| ARRY 520 hydrochloride | ARRY 520 hydrochloride is a kinesin spindle protein (Ksp) inhibitor with potential antineoplastic activity. Synonyms: Filanesib hydrochloride; (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, hydrochloride (1:1), (2S)-; ARRY-520 hydrochloride. Grade: 95%. CAS No. 1385020-40-5. Molecular formula: C20H23ClF2N4O2S. Mole weight: 456.94. | |
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