Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Fipi | FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 939055-18-2. Molecular formula: C23H24FN5O2. Mole weight: 421.47. Purity: 0.9982. Canonical SMILES: O=C(C(N1)=CC2=C1C=CC(F)=C2)NCCN3CCC(N4C5=CC=CC=C5NC4=O)CC3. Product ID: ACM939055182. Alfa Chemistry ISO 9001:2015 Certified. Categories: FIPIMA. |  |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Synonyms: 5-Fluoro-2-Indolyl des-Chlorohalopemide; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide; 5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide. Grades: >98 %. CAS No. 939055-18-2. Molecular formula: C23H24FN5O2. Mole weight: 421.47. |  |
| FIPI | FIPI. Group: Biochemicals. Grades: Purified. CAS No. 939055-18-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| FIPI hydrochloride | FIPI hydrochloride is an inhibitor of phospholipase D (PLD) (IC50 values of 20-25 nM for both PLD1 and PLD2), which is an enzyme catalyzing the hydrolysis of phosphatidylcholine to form phosphatidic acid. FIPI blocks in vivo phosphatidic acid (PA) production with subnanomolar potency. FIPI is a candidate therapeutic for autoimmunity and cancer metastasis. Uses: Potential treatment of autoimmunity and cancer metastasis. Synonyms: AOB33782; AKOS024457709; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride; 5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1781834-93-2. Molecular formula: C23H24FN5O2.HCl. Mole weight: 457.93. | |
| FIPI hydrochloride hydrate | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| PLD Inhibitor, FIPI | A cell-permeable, PLD1/2 inhibitor (IC50=1nM and 10nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50=20nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic b-cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 421.2. US Biological Life Sciences. | Worldwide |
| PLD Inhibitor, FIPI | The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications. Group: Fluorescence/luminescence spectroscopy. | |
Our database is helping our users find suppliers everyday.
