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| Product | Description | |
|---|---|---|
| Flumatinib mesylate | Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC 50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HHGV678 mesylate. CAS No. 895519-91-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13905. |  |
| Flumatinib Mesylate | Flumatinib mesylate, a derivative of imatinib, is a multi-kinase inhibitor for c-Abl, PDGFRβ and c-Kit. It is currently in Phase I and II clinical trials in China for the treatment of chronic myelogenous leukemia (CML). It effectively overcomes drug resistance of certain KIT mutants. It can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. Synonyms: HH-GV-678 mesylate. Grades: >98%. CAS No. 895519-91-2. Molecular formula: C30H33F3N8O4S. Mole weight: 658.69. |  |
| Flumatinib Mesylate Impurity 1 | Flumatinib Mesylate Impurity 1 is an impurity of Flumatinib Mesylate, a targeted therapy drug employed to treat chronic myeloid leukemia (CML). Synonyms: 4-((4-Methylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)benzoic acid. Grades: > 95%. CAS No. 859027-02-4. Molecular formula: C14H17F3N2O2. Mole weight: 302.30. | |
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