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| Product | Description | |
|---|---|---|
| FPS-ZM1 | FPS-ZM1 is a high-affinity RAGE inhibitor with a K i of 25 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 945714-67-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19370. |  |
| FPS-ZM1 | FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. It binds exclusively to RAGE and inhibits β-secretase activity and Aβ production. It also suppresses microglia activation and the neuroinflammatory response in brain. It penetrates the blood-brain barrier and binds to RAGE, thus reducing the protein levels of various cytokines. It inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. It is not toxic to mice and can easily cross the blood-brain barrier in vivo. It might be a novel therapeutic agent to treat AD patients. Uses: Fps-zm1 might be a novel therapeutic agent to treat ad patients. Synonyms: FPS-ZM1; FPS ZM1; FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1; N-benzyl-4-chloro-N-cyclohexylbenzaMide;4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide. Grades: >98 %. CAS No. 945714-67-0. Molecular formula: C20H22ClNO. Mole weight: 327.85. |  |
| RAGE Antagonist, FPS-ZM1 | A blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230nM, respectively, against Ab40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Ab40 and Ab42 into the brain. Also shown to suppress Ab-RAGE induced NF-kB activation and NF-kB-dependent transcription of b-secretase. Daily treatment of APPsw/0 murine AD model (1mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.CAS No:945714-67-0. Group: Biochemicals. Grades: Highly Purified. CAS No. 945714-67-0. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| RAGE Antagonist, FPS-ZM1 | RAGE Antagonist, FPS-ZM1, is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively, against A?40, HMGB1 & S100B, binding to sRAGE). Group: Fluorescence/luminescence spectroscopy. |  |
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