Fructose Bisphosphatase Suppliers USA
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Product | Description | |
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Fructose-1,6-bisphosphatase-1 Inhibitor Quick inquiry Where to buy Suppliers range | Fructose-1,6-bisphosphatase-1 (FBPase-1) inhibitor is a cell-permeable benzoxazolo-sulfonamide compound functioning by blocking human FBPase-1 enzymatic activity with an IC50 value of 3.4 μM (Ki = 1.1 μM). Synonyms: F1,6BPase-1 Inhibitor; FBP1 Inhibitor; FBPase-1 Inhibitor; 2,5-dichloro-N-(5-chloro-2-benzoxazolyl)-benzenesulfonamide. Grades: ≥98%. CAS No. 883973-99-7. Molecular formula: C13H7Cl3N2O3S. Mole weight: 377.6. | |
1,6-Dichloro-1,6-dideoxy-D-fructose Quick inquiry Where to buy Suppliers range | 1,6-Dichloro-1,6-dideoxy-D-fructose, a chemical compound extensively utilized in the biomedical sphere, manifests enzymatic inhibitory properties against fructose-1,6-bisphosphatase, a vital enzyme involved in gluconeogenesis. Epidemiological evidence suggests its potential effectiveness as a therapeutic agent to combat debilitating ailments such as Type 2 diabetes and other closely related metabolic dysfunctions. | |
D-Fructose-1,6-diphosphate trisodium salt octahydrate Quick inquiry Where to buy Suppliers range | UsesCardioprotectant for ischemic disorders.;UsesD-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Synonyms: D-Fructose-1,6-bisphosphate trisodium salt octahydrate. CAS No. 81028-91-3. Molecular formula: C6H11Na3O12P2 8H2O. Mole weight: 550.18. | |
PFK-158 Quick inquiry Where to buy Suppliers range | PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells. Synonyms: PFK158; PFK 158; PFK158; ACTPFK158. Grades: >98%. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29. | |
PFKFB3 Inhibitor, 3PO (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one) Quick inquiry Where to buy Suppliers range | A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Sulfur trioxide N,N-dimethylformamide Complex Quick inquiry Where to buy Suppliers range | Sulfur trioxide N,N-dimethylformamide Complex is a reagent used to prepare aminopyridines which are inhibitors of tetrameric fructose-1,6-bisphosphatase. Group: Biochemicals. Grades: Highly Purified. CAS No. 29584-42-7. Pack Sizes: 1g, 10 g. Molecular Formula: C3H7NO4S, Molecular Weight: 153.16. US Biological Life Sciences. | Worldwide |