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| Product | Description | |
|---|---|---|
| Fructose-1,6-bisphosphatase-1 Inhibitor | Fructose-1,6-bisphosphatase-1 (FBPase-1) inhibitor is a cell-permeable benzoxazolo-sulfonamide compound functioning by blocking human FBPase-1 enzymatic activity with an IC50 value of 3.4 μM (Ki = 1.1 μM). Synonyms: F1,6BPase-1 Inhibitor; FBP1 Inhibitor; FBPase-1 Inhibitor; 2,5-dichloro-N-(5-chloro-2-benzoxazolyl)-benzenesulfonamide. Grades: ≥98%. CAS No. 883973-99-7. Molecular formula: C13H7Cl3N2O3S. Mole weight: 377.6. |  |
| Fructose 1,6-bisphosphatase from Human, Recombinant | Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) is an enzyme in the liver that converts fructose-1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis. Fructose bisphosphatase catalyses the reverse of the reaction which is catalysed by phosphofructokinase, which is involved in the process of glycolysis. These enzymes only catalyse the reaction in one direction each, and are regulated by metabolites such as fructose 2,6-bisphosphate so that high activity of one of the two enzymes is accompanied by low activity of the other. It is involved in many different metabolic pathways and found in most organisms. FBPase requires metal ions for catalysis (Mg2+ and Mn2+ being preferred) and the enzyme is potently inhibited by Li+. Group: Enzymes. Synonyms: Fructose-bisphosphatase; EC 3.1.3.11; FBPase; Hexose diphosphatase. Enzyme Commission Number: EC 3.1.3.11. Purity: > 90% (densitometry). FBPase. Mole weight: 36.8 kDa. Activity: 1525 pmol/min/ug. Storage: Stable for > 6 months at -80°C. Form: Liquid. Storage Buffer: 50 mM potassium phosphate pH-7.4, 50 mM sodium chloride, 0.5 mM ethylenediaminetetraaceticacid, and 2.5% glycerol. Source: E. coli. Species: Human. Fructose-bisphosphatase; EC 3.1.3.11; FBPase; Hexose diphosphatase. Cat No: NATE-1576. |  |
| fructose-bisphosphatase | The animal enzyme also acts on sedoheptulose 1,7-bisphosphate. Group: Enzymes. Synonyms: hexose diphosphatase; FBPase; fructose 1,6-diphosphatase; fructose 1,6-diphosphate phosphatase; D-fructose 1,6-diphosphatase; fructose 1,6-bisphosphatase; fructose diphosphatase; fructose diphosphate phosphatase; fructose bisphosphate phosphatase; fructose 1,6-bisphosphate 1-phosphatase; fructose 1,6-bisphosphate phosphatase; hexose bisphosphatase; D-fructose-1,6-bisphosphate phosphatase. Enzyme Commission Number: EC 3.1.3.11. CAS No. 9001-52-9. FBPase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3614; fructose-bisphosphatase; EC 3.1.3.11; 9001-52-9; hexose diphosphatase; FBPase; fructose 1,6-diphosphatase; fructose 1,6-diphosphate phosphatase; D-fructose 1,6-diphosphatase; fructose 1,6-bisphosphatase; fructose diphosphatase; fructose diphosphate phosphatase; fructose bisphosphate phosphatase; fructose 1,6-bisphosphate 1-phosphatase; fructose 1,6-bisphosphate phosphatase; hexose bisphosphatase; D-fructose-1,6-bisphosphate phosphatase. Cat No: EXWM-3614. | |
| PFKFB3 Inhibitor, 3PO (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one) | A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| 1,6-Dichloro-1,6-dideoxy-D-fructose | 1,6-Dichloro-1,6-dideoxy-D-fructose, a chemical compound extensively utilized in the biomedical sphere, manifests enzymatic inhibitory properties against fructose-1,6-bisphosphatase, a vital enzyme involved in gluconeogenesis. Epidemiological evidence suggests its potential effectiveness as a therapeutic agent to combat debilitating ailments such as Type 2 diabetes and other closely related metabolic dysfunctions. | |
| D-Fructose-1,6-diphosphate trisodium salt octahydrate | UsesCardioprotectant for ischemic disorders.;UsesD-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Synonyms: D-Fructose-1,6-bisphosphate trisodium salt octahydrate. CAS No. 81028-91-3. Molecular formula: C6H11Na3O12P2 8H2O. Mole weight: 550.18. | |
| D-Fructose-6-phosphate disodium | D-Fructose 6-phosphate disodium is an endogenous metabolite. D-Fructose 6-phosphate disodium can be obtained by hydrolysis of Fructose-1,6-bisphosphatase ( FBPase ). D-Fructose-6-phosphate disodium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose-6-phosphate disodium can be used to detect glucosamine-6-phosphate synthase and TAL activities. D-Fructose 6-phosphate can be used to study Lewy body dementia. Uses: Scientific research. Group: Natural products. CAS No. 26177-86-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-113407A. |  |
| FBPase-IN-1 | FBPase-IN-1 is a potent FBPase (Fructose-1,6-bisphosphatase) inhibitor for Type 2 diabetes (T2D) study with an IC 50 of 0.22 μM. FBPase-IN-1 can reduce blood glucose levels and ameliorate glucose tolerance. FBPase-IN-1 modifies the C128 site, regulates the N125-S124-S123 allosteric pathway of FBPase and affects the catalytic activity of FBPase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 20362-54-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146725. | |
| ferredoxin:thioredoxin reductase | The enzyme contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11 (fructose-bisphosphatase), EC 3.1.3.37(sedoheptulose-bisphosphatase) and EC 2.7.1.19 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction. Group: Enzymes. Enzyme Commission Number: EC 1.8.7.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1681; ferredoxin:thioredoxin reductase; EC 1.8.7.2. Cat No: EXWM-1681. | |
| fructose-2,6-bisphosphate 2-phosphatase | The enzyme copurifies with EC 2.7.1.105 6-phosphofructo-2-kinase. (cf. EC 3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase). Group: Enzymes. Synonyms: fructose-2,6-bisphosphatase; D-fructose-2,6-bisphosphate 2-phosphohydrolase. Enzyme Commission Number: EC 3.1.3.46. CAS No. 81611-75-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3650; fructose-2,6-bisphosphate 2-phosphatase; EC 3.1.3.46; 81611-75-8; fructose-2,6-bisphosphatase; D-fructose-2,6-bisphosphate 2-phosphohydrolase. Cat No: EXWM-3650. | |
| Native Bacillus stearothermophilus Fructose-6-phosphate Kinase | Fructose-1,6-bisphosphatase (FBP) is an important enzyme in glucose metabolism. It catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate. Fructose-6-phosphate kinase converts fructose-6-phosphate into fructose 1,6-bisphophate in the rate limiting step of the glycolysis cycle. Bacillus stearothermophilus phosphofructokinase (bspfk) is a homotetramer that is allosterically inhibited by phosphoenolpyruvate (pep), which binds along one dimer-dimer interface. Applications: Fructose-6-phosphate kinase from bacillus stearothermophilus was shown to interact with neuronal nitric oxide synthase (nnos) causing a defect in glycolytic metabolism and increased fatigability in dystrophic muscle. Group: Enzymes. Sy. Enzyme Commission Number: EC 2.7.1.11. CAS No. 9001-80-3. FBP. Activity: > 50 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing phosphate buffer salt. Source: Bacillus stearothermophilus. EC 2.7.1.11; phosphohexokinase; phosphofructokinase I; phosphofructokinase (phosphorylating); 6-phosphofructose 1-kinase; ATP-dependent phosphofructokinase; D-fructose-6-phosphate 1-phosphotransferase; fructose 6-phosphate kinase; fructose 6-phosphokinase; nucleotide triphosphate-dependent phosphofructokinase; phospho-1,6-fructokinase; PFK; 9001-80-3. Cat No: NATE-0252. | |
| Native Propionibacterium freudenreichii (shermanII) Fructose-6-phosphate Kinase, Pyrophosphate-dependent | Fructose-1,6-bisphosphatase (FBP) is an important enzyme in glucose metabolism. It catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate. Fructose-6-phosphate kinase converts fructose-6-phosphate into fructose 1,6-bisphophate in the rate limiting step of the glycolysis cycle. Applications: Fbp was used to study the kinetic mechanism of pyrophosphate-dependent phosphofructokinase from propionibacterium freudenreichii. Group: Enzymes. Synonyms: EC 2.7.1.90; 6-phosphofructokinase (pyrophosphate); pyrophosphate-fructose 6-phosphate 1-phosphotransferase; inorganic pyrophosphate-dependent phosphofructokinase; inorganic pyrophosphate-phosphofructokinase; pyrophospha. Enzyme Commission Number: EC 2.7.1.90. CAS No. 55326-40-4. FBP. Activity: 4.0-8.0 units/mg protein. Storage: -20°C. Form: lyophilized powder; Contains imidazole salts and stabilizer. Source: Propionibacterium freudenreichii (shermanII). EC 2.7.1.90; 6-phosphofructokinase (pyrophosphate); pyrophosphate-fructose 6-phosphate 1-phosphotransferase; inorganic pyrophosphate-dependent phosphofructokinase; inorganic pyrophosphate-phosphofructokinase; pyrophosphate-dependent phosphofructo-1-kinase; pyrophosphate-fructose 6-phosphate phosphotransferase; 55326-40-4. Cat No: NATE-0253. | |
| PFK-158 | PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells. Synonyms: PFK158; PFK 158; PFK158; ACTPFK158. Grades: >98%. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29. | |
| Sulfur trioxide N,N-dimethylformamide Complex | Sulfur trioxide N,N-dimethylformamide Complex is a reagent used to prepare aminopyridines which are inhibitors of tetrameric fructose-1,6-bisphosphatase. Group: Biochemicals. Grades: Highly Purified. CAS No. 29584-42-7. Pack Sizes: 1g, 10 g. Molecular Formula: C3H7NO4S, Molecular Weight: 153.16. US Biological Life Sciences. | Worldwide |
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