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| Product | Description | |
|---|---|---|
| Furamidine dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Furamidine dihydrochloride | Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC 50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC 50 s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DB75 dihydrochloride; NSC 305831 dihydrochloride. CAS No. 55368-40-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110137. |  |
| Furamidine dihydrochloride | Furamidine dihydrochloride is a protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM) in the class of antimicrobial and antiparasitic agents. It was shown to inhibit cell proliferation in leukemia cell lines. Synonyms: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 55368-40-6. Molecular formula: C18H16N4O.2HCl. Mole weight: 377.27. |  |
| Furamidine Dihydrochloride | Furamidine is a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines. Group: Biochemicals. Alternative Names: 4, 4'- (2, 5-Furandiyl) bis Benzene carboximidamide Dihydrochloride; 2,5-Bis(4-amidinophenyl)furan Dihydrochloride; 2,5-Bis(4-guanylphenyl)furan Dihydrochloride; WR 199385. Grades: Highly Purified. CAS No. 55368-40-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Pafuramidine | DB289 (pafuramidine maleate; 2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) is a prodrug of DB75 (furamidine dihydrochloride; 2,5-bis(4-guanylphenyl)furan dihydrochloride), an aromatic dication related to pentamidine that has demonstrated good efficacy against African trypanosomiasis, Pneumocystis carinii pneumonia, and malaria, but lacks adequate oral availability. Synonyms: DB289; DB-289; DB 289; Pafuramidine. Grades: >98%. CAS No. 186953-56-0. Molecular formula: C20H20N4O3. Mole weight: 364.4. | |
| 4,4'-(2,5-Furandiyl)bis-Benzenecarboximidic Acid Diethyl Ester Dihydrochloride | Used in the preparation of Furamidine an antimicrobial and antiparasitic agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 261778-65-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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