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| Product | Description | |
|---|---|---|
| G-5555 | G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648863-90-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-19635. |  |
| G-5555 | G-5555 is a selective PAK1 Inhibitor (Ki=3.7 nM) with low clearance (CLp = 3.4 mL/min/kg) and high oral bioavailability (F = 72%). IC50: PAK2= 11 nM, SIK2= 9 mM, KHS1= 10 mM. Synonyms: G - 5555; G 5555; G5555; 8-[(5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one59T8-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7. CAS No. 1648863-90-4. Molecular formula: C25H25ClN6O3. Mole weight: 492.96. |  |
| G-5555 hydrochloride | G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2319590-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-19635A. | |
| G-5555 hydrochloride | G-5555 hydrochloride is the hydrochloride salt of G-5555 which is a potent and selective p21-activated kinase 1 (PAK1) inhibitor (Ki = 3.7 nM). G-5555 was potent, showing good activity in the pMEK cellular assay, had improved permeability, and importantly, displayed low hERG channel activity (<50% inhibition at 10 μM). Synonyms: 8-[(5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one;hydrochloride; G-5555 (hydrochloride); G 5555 (hydrochloride); G5555 (hydrochloride). Molecular formula: C25H26Cl2N6O3. Mole weight: 529.42. | |
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