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| Product | Description | |
|---|---|---|
| Gabexate mesylate | Gabexate is a serine protease inhibitor that inhibits trypsin (IC50= 9.4μM), plasmin (IC50= 30μM), plasma kallikrein (IC50= 41μM) and thrombin (IC50= 110μM). It is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. Synonyms: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate; Gabexate; Gabexate mesylate; gabexate mesilate. Arodate; Megacart; Megacert; Mesyl Gabexate; Arodate. CAS No. 56974-61-9. Molecular formula: C17H27N3O7S. Mole weight: 417.48. |  |
| Gabexate mesylate | Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K i s of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K i s of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FOY. CAS No. 56974-61-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0385. |  |
| Gabexate Mesylate | Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Group: Biochemicals. Alternative Names: 4-[[6-[ (Aminoiminomethyl) amino]-1-oxohexyl]oxy]benzoic Acid Ethyl Ester Monomethanesulfonate; Arodate; FOY; FOY 007; FOY-S 983; Gabexate Mesilate; Gabexate Monomethanesulfonate; Megacert; Mesyl Gabexate. Grades: Highly Purified. CAS No. 56974-61-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Gabexate | Gabexate mesylate is a serine protease inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis. Uses: Serine protease inhibitor. Synonyms: GABEXATE; GabexateMesylateBase; [N'-[5- (4-ethoxycarbonylphenoxy) carbonylpentyl]carbamimidoyl]azanium methanesulfonate;4-[(6-Guanidinohexanoyl)oxy]benzoic acid ethyl ester;4-[[6-[[Amino(imino)methyl]amino]-1-oxohexyl]oxy]benzoic acid ethyl ester. Grades: ≥98%. CAS No. 39492-01-8. Molecular formula: C16H23N3O4. Mole weight: 321.375. | |
| Camostat Mesylate | Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor. Camostat mesilate is a serine protease inhibitor that inhibits plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. It reduces weight gain and improves metabolism in obese rodent models. It is in clinical use (in Japan) for pancreatitis. Camostat has been found to inhibit influenza virus replication in human tracheal epithelial cells and is also a direct prostasin inhibitor which may be useful in reducing sodium transport in cystic fibrosis. Additionally it has been shown to reduce infection of Calu-3 lung cells by SARS-CoV-2 (the coronavirus responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming. Group: Biochemicals. Alternative Names: 4- [ [4- [ (Aminoiminomethyl) amino] benzoyl] oxy] benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate; FOY 305; FOY-S 980; Foipan. Grades: Highly Purified. CAS No. 59721-29-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
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