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| Product | Description | |
|---|---|---|
| GANT61 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| GANT61 | GANT61 is a cell-permeable hexahydropyrimidine compound. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC?? = 5uM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 500579-04-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C27H35N5. US Biological Life Sciences. |  Worldwide |
| GANT61 | GANT61 is a small-molecule inhibitor of glioma-associated oncogene 1 (GLI1)- and GLI2-mediated transcription at the nuclear level that exerts its effect by preventing DNA binding. It has been demonstrated to induce cell death against Ewing's sarcoma family tumor (ESFT) cell lines in a dose-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GANT61; GANT-61; GANT 61; NSC 136476. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 500579-04-4. Molecular formula: C27H35N5. Mole weight: 429.6. Purity: >98%. IUPACName: 2,2'-((2-(pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene))bis(N,N-dimethylaniline). Canonical SMILES: CN(C)C1=CC=CC=C1CN2C(C3=CC=NC=C3)N(CC4=CC=CC=C4N(C)C)CCC2. Product ID: ACM500579044. Alfa Chemistry ISO 9001:2015 Certified. |  |
| GANT-61 | GANT 61 is a GLI antagonist that inhibits GLI1 activation of gene expression with an IC50 value of 5 μM. Synonyms: GANT61; GANT-61; GANT 61; NSC 136476; NSC136476; NSC-136476; 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline. Grades: >98%. CAS No. 500579-04-4. Molecular formula: C27H35N5. Mole weight: 429.612. |  |
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