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| Product | Description | |
|---|---|---|
| GDC-0927 | GDC-0927 (SRN-927) is a potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SRN-927. CAS No. 1642297-01-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111484. |  |
| GDC-0927 | GDC-0927 (SRN-927) is a selective oral estrogen receptor degrader (SERD) in a phase I clinical trial for the treatment of postmenopausal women with locally advanced or metastatic estrogen receptor positive breast cancer. Study shows well tolerability and clinical effect. Uses: The potential therapy of breast cancer caused by estrogen disorder. Synonyms: SRN-927; SRN 927; SRN927; GDC-0927; GDC 0927; GDC0927. CAS No. 1642297-01-5. Molecular formula: C28H28FNO4. Mole weight: 461.52. |  |
| GDC-0927 Racemate | GDC-0927 Racemate is an estrogen receptor degrader, which can effectively inhibit ER-α activity with an IC50 of 0.2 nM. It is used to study ER-related diseases. Synonyms: SRN-927 Racemate; 2H-1-Benzopyran-6-ol, 2-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-. Grade: ≥95%. CAS No. 1443983-36-5. Molecular formula: C28H28FNO4. Mole weight: 461.52. | |
| GNE-274 | GNE-274, a non-degrader structurally related to GDC-0927 (ER degrader), does not induce ER turnover and acts as a partial ER agonist in breast cancer cell lines. It increases chromatin accessibility of ER-DNA binding sites, while GDAC-0927 does not. It is a potent ER ligand-binding domain (LBD) inhibitor and can be used for the study of cancer. Synonyms: 2H-1-Benzopyran-6-ol, 3-(3-hydroxyphenyl)-4-methyl-2-[4-[(1-propyl-3-azetidinyl)methoxy]phenyl]-, (2S)-. CAS No. 2369048-69-9. Molecular formula: C29H31NO4. Mole weight: 457.56. | |
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