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| Product | Description | |
|---|---|---|
| Gedunin | Gedunin Inhibitor. Uses: Scientific use. Product Category: T21883. CAS No. 2753-30-2. |  |
| Gedunin | Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research [3]. Uses: Scientific research. Group: Natural products. CAS No. 2753-30-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107577. |  |
| Gedunin | Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 2753-30-2. Molecular formula: C28H34O7. Mole weight: 482.57. Purity: 0.98. Product ID: ACM2753302. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Gedunin | Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). It also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively). Grades: >98%. CAS No. 2753-30-2. Molecular formula: C28H34O7. Mole weight: 482.57. |  |
| Gedunin | Method for Determining Identity: Group: Biochemicals. Alternative Names: (1S, 3aS, 4aR, 4bS, 5R, 6aR, 10aR, 10bR, 12aS) -5- (Acetyloxy) -1- (3-furanyl) -1, 5, 6, 6a, 7, 10a, 10b, 11, 12, 12a, decahydro-4b, 7, 7, 10a, 12a, -pentamethyloxireno [c]phenanthro [1, 2-d]pyran-3, 8 (3aH, 4bH) -dione. Grades: Purified. CAS No. 2753-30-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) | A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome / pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
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