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| Product | Description | |
|---|---|---|
| Genz-123346 | Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. It does not inhibit α-glucosidase or glucocerebrosidase. It lowered glucose and A1C levels and improved glucose tolerance in the Zucker diabetic fatty rat. Synonyms: Genz-123346; Genz123346; Genz 123346. Grades: >98%. CAS No. 943344-58-9. Molecular formula: C52H82N4O14. Mole weight: 987.23. |  |
| Genz-123346 Free base | Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function. Synonyms: Genz-123346; Genz123346; Genz 123346. CAS No. 491833-30-8. Molecular formula: C24H38N2O4. Mole weight: 418.57. | |
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