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| Product | Description | |
|---|---|---|
| Gilteritinib | Gilteritinib, also known as (ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. In invitro, among the 78 tyrosine kinases tested, ASP2215 inhibited FLT3, LTK, ALK, and AXL kinases by over 50% at 1 nM with an IC50 value of 0.29 nM for FLT3, approximately 800-fold more potent than for c-KIT, the inhibition of which is linked to a potential risk of myelosuppression. ASP2215 inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. ASP2215 decreased tumor burden in bone marrow and prolonged the survival of mice intravenously transplanted with MV4-11 cells. ASP2215 may have potential use in treating AML. Synonyms: Gilteritinib; ASP2215; ASP-2215; ASP 2215. CAS No. 1254053-43-4. Molecular formula: C29H44N8O3. Mole weight: 552.724. |  |
| Gilteritinib | Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3 / AXL inhibitor with IC 50 s of 0.29 nM/0.73 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASP2215. CAS No. 1254053-43-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12432. |  |
| Gilteritinib hemifumarate | Gilteritinib hemifumarate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1254053-84-3. Molecular formula: C33H48N8O7. Mole weight: 668.8. Catalog: APB1254053843. |  |
| 6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide | 6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide. Uses: Designed for use in research and industrial production. Product Category: Pyrazines. Appearance: White Powder. CAS No. 1254053-43-4. Molecular formula: C29H44N8O3. Mole weight: 552.7. Purity: 0.95. Product ID: ACM1254053434. Alfa Chemistry ISO 9001:2015 Certified. Categories: Gilteritinib. |  |
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