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| Product | Description | |
|---|---|---|
| glutamate decarboxylase | A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate. Group: Enzymes. Synonyms: L-glutamic acid decarboxylase; L-glutamic decarboxylase; cysteic acid decarboxylase; L-glutamate α-decarboxylase; aspartate 1-decarboxylase; aspartic α-decarboxylase; L-aspartate-α-decarboxylase; γ-glutamate decarboxylase; L-glutamate 1-carboxy-lyase. Enzyme Commission Number: EC 4.1.1.15. CAS No. 9024-58-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4759; glutamate decarboxylase; EC 4.1.1.15; 9024-58-2; L-glutamic acid decarboxylase; L-glutamic decarboxylase; cysteic acid decarboxylase; L-glutamate α-decarboxylase; aspartate 1-decarboxylase; aspartic α-decarboxylase; L-aspartate-α-decarboxylase; γ-glutamate decarboxylase; L-glutamate 1-carboxy-lyase. Cat No: EXWM-4759. |  |
| hydroxyglutamate decarboxylase | A pyridoxal-phosphate protein. Group: Enzymes. Synonyms: 3-hydroxy-L-glutamate 1-carboxy-lyase. Enzyme Commission Number: EC 4.1.1.16. CAS No. 9024-59-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4760; hydroxyglutamate decarboxylase; EC 4.1.1.16; 9024-59-3; 3-hydroxy-L-glutamate 1-carboxy-lyase. Cat No: EXWM-4760. | |
| L-Glutamate Decarboxylase (Crude Enzyme) | Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO 2. In mammals, GAD exists in two isoforms encoded by two different genes - GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD1 and GAD2 are expressed in the brain where GABA is used as a neurotransmitter, GAD2 is also expressed in the pancreas. At least two more forms, GAD25 and GAD44 (embryonic; EGAD) are described in the developing brain. They are coded by the alternative transcripts of GAD1, I-80 and I-86: GAD25 is coded by both, GAD44 - only by I-80.This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Medicine; synthesis; diagnostics; food industry. Group: Enzymes. Synonyms: L-glutamic acid. Enzyme Commission Number: EC 4.1.1.15. CAS No. 9024-58-2. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. L-glutamic acid decarboxylase; L-glutamic decarboxylase; cysteic acid decarboxylase; L-glutamate α-decarboxylase; aspartate 1-decarboxylase; aspartic α-decarboxylase; L-aspartate-α-decarboxylase; γ-glutamate decarboxylase; L-glutamate 1-carboxy-lyase. Pack: 100ml. Cat No: NATE-1846. | |
| 4-Deoxypyridoxine 5'-phosphate | 4-Deoxypyridoxine 5'-phosphate, a pyridoxal 5'-phosphate analogue, is a sphingosine 1-phosphate (S1P) inhibitor that inhibits ornithine decarboxylase activity with a Ki of 60 μM. It is a competitive inhibitor of the activation of glutamate apodecarboxylase by pyridoxal 5'-phosphate (Ki = 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase. Synonyms: 5-hydroxy-4,6-dimethyl-3-pyridinemethanol, 3-(dihydrogen phosphate); NSC 29870; 5-(Phosphonooxymethyl)-2,4-dimethyl-3-pyridinol; (5-hydroxy-4,6-dimethyl-3-pyridinyl)methyl dihydrogen phosphate; 3-Pyridinemethanol, 5-hydroxy-4,6-dimethyl-, α-(dihydrogen phosphate); Deoxypyridoxine-P. Grade: ≥98%. CAS No. 883-84-1. Molecular formula: C8H12NO5P. Mole weight: 233.16. |  |
| [butirosin acyl-carrier protein]-L-glutamate ligase | Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC 4.1.1.95, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second L-glutamate molecule.Requires Mg2+ or Mn2+, and activity is enhanced in the presence of Mn2+. Group: Enzymes. Synonyms: [BtrI acyl-carrier protein]-L-glutamate ligase; BtrJ. Enzyme Commission Number: EC 6.2.1.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5697; [butirosin acyl-carrier protein]-L-glutamate ligase; EC 6.2.1.39; [BtrI acyl-carrier protein]-L-glutamate ligase; BtrJ. Cat No: EXWM-5697. | |
| Chelidamic acid | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a K i of 33 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 138-60-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W016349. |  |
| Chelidamic Acid | Chelidamic Acid is considered as one of the most potent "conformationally restricted glutamate analogs" as an inhibitor of glutamate decarboxylase. Group: Biochemicals. Alternative Names: 1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic Acid; 4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic Acid; NSC 3983; Chelidamic Acid; 4-Hydroxypyridine-2,6-dicarboxylic acid, Hydrate. Grades: Highly Purified. CAS No. 138-60-3. Pack Sizes: 10g, 25g, 50g. Molecular Formula: C?H?NO?, Molecular Weight: 183.12 (anhy). US Biological Life Sciences. |  Worldwide |
| Chelidonic acid | Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 [1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K i of 1.2 μM [2]. Uses: Scientific research. Group: Natural products. CAS No. 99-32-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W041489. | |
| Chelidonic Acid | Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-oxopyran-2,6-dicarboxylic acid. Product Category: Inhibitors. CAS No. 99-32-1. Molecular formula: C7H4O6. Mole weight: 184.1. Purity: 0.97. IUPACName: 4-oxopyran-2,6-dicarboxylic acid. Canonical SMILES: C1=C(OC(=CC1=O)C(=O)O)C(=O)O. Density: 1.821 g/cm³. ECNumber: 202-749-0. Product ID: ACM99321. Alfa Chemistry ISO 9001:2015 Certified. |  |
| DL-Allylglycine | DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: 2-Aminopent-4-enoic acid. CAS No. 7685-44-1. Pack Sizes: 5 g; 10 g; 25 g; 100 g. Product ID: HY-W023493. | |
| Gabazine (SR-95531, 2- (3-Carboxypropyl) -3-amino-6- (4-methoxyphenyl) pyridazinium ) | A specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites. Group: Biochemicals. Alternative Names: SR-95531, 2- (3-Carboxypropyl) -3-amino-6- (4-methoxyphenyl) pyridazinium. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| L-Allylglycine | L-Allylglycine is a glycine derivative that acts as an inhibitor of glutamate decarboxylase. L-Allylglycine blocks the synthesis of GABA, inducing panic-like responses in rat models. Synonyms: (S)-2-aminopent-4-enoic acid; (S)-(-)-2-Amino-4-pentenoic acid. Grade: ≥ 98% (HPLC, Chiral purity). CAS No. 16338-48-0. Molecular formula: C5H9NO2. Mole weight: 115.1. | |
| L-Asparagine Monohydrate | L-Asparagine is used in cell culture media and is a component of MEM non-essential amino acids solution. L-Asparagine has been shown to enhance ornithine decarboxylase activity in cultured human colon adenocarcinoma Caco-2 cells and in cultured IEC-6 intestinal epithelial cells. Spore germination in Bacillus subtilis has been increased in the presence of L-asparagine. L-Asparagine, a proteinogenic amino acid, from non-animal source is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies. It has also been used as a component of LHC basal media for the culture of human airway epithelial cells.The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated to give a terminal amine group. This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamine, in the reaction of aspartate and glutamine in the presence of ATP to yield asparagine and glutamate. In vivo, asparagine is hydrolyzed to aspartate and NH4+ by asparaginase. Asparagine is also an important amino acid in glycopeptide bonds, via N-glycosyl linkages to the sugar rings. Group: Biochemicals. Alternative Names: (S)-2-Aminosuccinic acid 4-amide; (S)-(+)-2-Aminosuccinamic acid; L-Aspartic acid 4-amide; L-Asn-OH·H2O. Grades: Cell Culture Grade. CAS No. 5794-13-8. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula: C4H8N2O3 H2O, Molecular Weight: 150.13. US Biological Life Sciences. | Worldwide |
| Maleic Acid | Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Kyselina maleinova. Product Category: Inhibitors. Appearance: White solid. CAS No. 110-16-7. Molecular formula: C4H4O4. Mole weight: 116.07. Purity: 0.99. IUPACName: (Z)-But-2-enedioic acid. Canonical SMILES: C(=CC(=O)O)C(=O)O. Density: 1.59 g/mL at 25 °C(lit.). Product ID: ACM110167. Alfa Chemistry ISO 9001:2015 Certified. | |
| Maleic Acid | Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes. Uses: Scientific research. Group: Natural products. CAS No. 110-16-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-Y0367. | |
| NMDA Antagonist XI, N1-dansyl-spermine (NMDA Channel Blocker, N1-dansyl-spermine, N1-DnsSpm) | An N-sulfonyl-polyamine that acts as a potent and more specific antagonist ofnMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13uM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58uM) and diminishes the induction of ornithine decarboxylase. At higher concentration (100uM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Thiothiamine | Thiothiamine is an impurity of Thiamine. Thiothiamine inhibits the activity of glutamate decarboxylase and decreases the concentration of GABA in brain tissue. Thiamine Impurity A. Group: Biochemicals. Alternative Names: 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-2(3H)-thiazolethione; SB; Thiamin Thiothiazolone; Thiothiamin; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-4-thiazoline-2-thione; Thioxothiamine; Thiamine Impurity A. Grades: Highly Purified. CAS No. 299-35-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Anti-Glutamic Acid Decarboxylase 65 (514-530) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. |  |
| Anti-Glutamic Acid Decarboxylase 65 (5-22) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Glutamic Acid Decarboxylase 65/67 antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Dimethyl dicarbonate | Dimethyl dicarbonate (DMDC) is an organic compound which is a Colorless liquid with a sharp odor at room temperature. It is primarily used as a beverage preservative, processing aid, or sterilant (INS No. 242), and acts by inhibiting the enzymes acetate kinase and L-glutamic acid decarboxylase. It has also been proposed that DMDC inhibits the enzymes alcohol dehydrogenase and glyceraldehyde 3-phosphate dehydrogenase by causing the methoxycarbonylation of their histidine components. Uses: Designed for use in research and industrial production. Additional or Alternative Names: methoxycarbonyl methyl carbonate;DMPC Dimethyl pyrocarbonate Pyrocarbonic acid dimethyl ester. Product Category: Heterocyclic Organic Compound. CAS No. 4525-33-1. Molecular formula: C4H6O5. Mole weight: 134.09. IUPACName: methoxycarbonyl methyl carbonate. Canonical SMILES: COC(=O)OC(=O)OC. Density: 1.242 g/cm³. Product ID: ACM4525331. Alfa Chemistry ISO 9001:2015 Certified. | |
| L-glutamyl-[BtrI acyl-carrier protein] decarboxylase | Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein. Group: Enzymes. Synonyms: btrK (gene name). Enzyme Commission Number: EC 4.1.1.95. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4845; L-glutamyl-[BtrI acyl-carrier protein] decarboxylase; EC 4.1.1.95; btrK (gene name). Cat No: EXWM-4845. | |
| Monoclonal Anti-Glutamic Acid Decarboxylase 65 antibody produced in mouse | clone GAD-6, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Glutamic Acid Decarboxylase 67 (GAD67) antibody produced in mouse | clone K-87, purified antibody. Group: Fluorescence/luminescence spectroscopy. | |
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