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| Product | Description | |
|---|---|---|
| Bifunctional Chimeras of Glutamylcysteine Synthetase and Glutathione Synthetase (Crude Enzyme) | GSH, and by extension GCL, is critical to cell survival. Nearly every eukaryotic cell, from plants to yeast to humans, expresses a form of the GCL protein for the purpose of synthesizing GSH. To further highlight the critical nature of this enzyme, genetic knockdown of GCL results in embryonic lethality. Furthermore, dysregulation of GCL enzymatic function and activity is known to be involved in the vast majority of human diseases, such as diabetes, Parkinson's disease, Alzheimers disease, COPD, HIV/AIDS, and cancer. This typically involves impaired function leading to decreased GSH biosynthesis, reduced cellular antioxidant capacity, and the in.se forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Agriculture; medicine; synthesis; biotechnology; pharmacology. Group: Enzymes. Enzyme Commission Number: EC 6.3.2.2/ 6.3.2.3. CAS No. 9023-64-7/9023-62-5. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. Bifunctional Chimeras of Glutamylcysteine Synthetase and Glutathione Synthetase; Glutamylcysteine Synthetase; Glutathione Synthetase. Pack: 100ml. Cat No: NATE-1859. |  |
| Bis(2-aminoethylthio)methane | Bis(2-aminoethylthio)methane is a potential inhibitor of γ-glutamylcysteine synthetase, the first enzyme in the glutathione biosynthesis pathway. Group: Biochemicals. Alternative Names: 2, 2'-[Methylenebis (thio)]bisethanamine. Grades: Highly Purified. CAS No. 22907-27-3. Pack Sizes: 2.5g. US Biological Life Sciences. |  Worldwide |
| Bis(2-aminoethylthio)methane Dihydrochloride | Bis(2-aminoethylthio)methane is a potential inhibitor of γ-glutamylcysteine synthetase, the first enzyme in the glutathione biosynthesis pathway. Group: Biochemicals. Alternative Names: 2, 2'-[Methylenebis (thio)]bisethanamine Dihydrochloride. Grades: Highly Purified. CAS No. 22965-82-8. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| Gamma-L-glutamyl-L-cysteine (γ-Glu-Cys) | γ-L-Glutamyl-L-cysteine (γ-Glu-Cys) is a substrate used for the biosynthesis of L-glutathione by glutathione synthetase(s). γ-Glu-Cys is generated by the cleavage of the Cys-Gly peptide bond of glutathione. It is also essential for the formation of phytochelatins, which are cysteine-rich thiol-reactive peptides. Group: Biochemicals. Alternative Names: γ-Glu-Cys; γ-L-Glutamyl-L-cysteine, des-Gly-glutathione reduced. Grades: Purified. CAS No. 636-58-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C8H14N2O5S, Molecular Weight: 250.27. US Biological Life Sciences. | Worldwide |
| Glutathione EP Impurity D | Glutathione EP Impurity D is a substrate used for the biosynthesis of L-glutathione by glutathione synthetase. It is used to study the active sites and kinetics of glutathione synthestase(s). It is also used in biological studies for the detection of thiols. Synonyms: γ-L-Glutamyl-L-cysteine; des-Gly-glutathione reduced form; γ-Glu-Cys; N-L-γ-glutamyl-; γ-Glutamylcysteine; N-(1-Carboxy-2-mercaptoethyl)-glutamine; L-gamma-Glutamyl-L-cysteine. Grade: > 95%. CAS No. 636-58-8. Molecular formula: C8H14N2O5S. Mole weight: 250.28. |  |
| glutathione synthase | This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). This enzyme participates in glutamate metabolism and glutathione metabolism. Group: Enzymes. Synonyms: glutathione synthetase; GSH synthetase. Enzyme Commission Number: EC 6.3.2.3. CAS No. 9023-62-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5746; glutathione synthase; EC 6.3.2.3; 9023-62-5; glutathione synthetase; GSH synthetase. Cat No: EXWM-5746. | |
| Glutathione Synthase 1 (Crude Enzyme) | This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). This product with the indicated enzyme activity was briefly purified from engineered E.coli. Applications: Biotechnology; analysis; synthesis. Group: Enzymes. Synonyms: glutathione synthetase; GSH synthetase. Enzyme Commission Number: EC 6.3.2.3. CAS No. 9023-62-5. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. glutathione synthetase; GSH synthetase. Pack: 100ml. Cat No: NATE-1860. | |
| Glutathione Synthase 2 (Crude Enzyme) | This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). This product with the indicated enzyme activity was briefly purified from engineered E.coli. Applications: Biotechnology; analysis; synthesis. Group: Enzymes. Synonyms: glutathione synthetase; GSH synthetase. Enzyme Commission Number: EC 6.3.2.3. CAS No. 9023-62-5. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. glutathione synthetase; GSH synthetase. Pack: 100ml. Cat No: NATE-1861. | |
| homoglutathione synthase | Not identical with EC 6.3.2.3 glutathione synthase. Group: Enzymes. Synonyms: homoglutathione synthetase; β-alanine specific hGSH synthetase. Enzyme Commission Number: EC 6.3.2.23. CAS No. 113875-72-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5741; homoglutathione synthase; EC 6.3.2.23; 113875-72-2; homoglutathione synthetase; β-alanine specific hGSH synthetase. Cat No: EXWM-5741. | |
| L-Buthionine-(S,R)-sulfoximine | L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 ?M, 8.6 ?M, and 29 ?M, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-Buthionine sulfoximine; L-BSO. CAS No. 83730-53-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-106376A. |  |
| L- Buthionine Sulfoximine | A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29uM in melanoma, breast, and ovarian tumor cells, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 83730-53-4. Pack Sizes: 100mg. Molecular Formula: C?H??N?O?S. US Biological Life Sciences. | Worldwide |
| leukotriene-C4 synthase | The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase. Group: Enzymes. Synonyms: leukotriene C4 synthetase; LTC4 synthase; LTC4 synthetase; leukotriene A4:glutathione S-leukotrienyltransferase; (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathioneleukotriene-transferase (epoxide-ring-opening); (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). Enzyme Commission Number: EC 4.4.1.20. CAS No. 90698-32-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5322; leukotriene-C4 synthase; EC 4.4.1.20; 90698-32-1; leukotriene C4 synthetase; LTC4 synthase; LTC4 synthetase; leukotriene A4:glutathione S-leukotrienyltransferase; (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathioneleukotriene-transferase (epoxide-ring-opening); (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). Cat No: EXWM-5322. | |
| Native Baker's yeast (S. cerevisiae) S-Acetyl-coenzyme A synthetase | Acetyl-coenzyme A synthetase catalyzes the production of acetyl-CoA. It is involved in histone acetylation in the nucleus. It may be involved in the growth of nonfermentable carbon sources such as glycerol. Acetyl-coenzyme A synthetase is induced by acetate, acetaldehyde and ethanol. Applications: S-acetyl-coenzyme a synthetase may be used to study various metabolic pathways, such as glycolysis, gluconeogenesis, pyruvate metabolism and co fixation. it may also be used in gene expression studies. Group: Enzymes. Synonyms: acetyl-CoA synthetase; acetyl activating enzyme; acetate thiokinase; acyl-activating enzyme; acetyl coenzyme A synthetase; acetic thiokinase; acetyl CoA ligase; acetyl C. Enzyme Commission Number: EC 6.2.1.1. CAS No. 9012-31-1. ACS. Activity: > 3 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing stabilizers as potassium phosphate, sucrose, and reduced glutathione. Source: Baker's yeast (S. cerevisiae). acetyl-CoA synthetase; acetyl activating enzyme; acetate thiokinase; acyl-activating enzyme; acetyl coenzyme A synthetase; acetic thiokinase; acetyl CoA ligase; acetyl CoA synthase; acetyl-coenzyme A synthase; short chain fatty acyl-CoA synthetase; short-chain acyl-coenzyme A synthetase; ACS; EC 6.2.1.1; 9012-31-1. Pack: Package size based on protein content. Cat No: NATE-0026. | |
| prostaglandin-D synthase | Brings about the opening of the epidioxy bridge. Some enzymes require glutathione. Group: Enzymes. Synonyms: prostaglandin-H2 Δ-isomerase; prostaglandin-R-prostaglandin D isomerase; PGH-PGD isomerase(5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate Δ-isomerase (incorrect); (5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase; prostaglandin endoperoxide Δ-isomerase; prostaglandin D synthetase. Enzyme Commission Number: EC 5.3.99.2. CAS No. 65802-85-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5510; prostaglandin-D synthase; EC 5.3.99.2; 65802-85-9; prostaglandin-H2 Δ-isomerase; prostaglandin-R-prostaglandin D isomerase; PGH-PGD isomerase(5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate Δ-isomerase (incorrect); (5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase; prostaglandin endoperoxide Δ-isomerase; prostaglandin D synthetase. Cat No: EXWM-5510. | |
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