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| Product | Description | |
|---|---|---|
| GMQ | GMQ is a ASIC (acid-sensing ion) channel activator with an EC 50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5361-15-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107757. |  |
| GMQ hydrochloride | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| GMQ hydrochloride | GMQ hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 5361-15-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| GMQ hydrochloride | GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. It alters the pH dependence of ASIC1a and ASIC1b with no effect on the activation curve of ASIC2a. Synonyms: GMQ monohydrochloride; GMQ HCl; NSC-403387 hydrochloride; NSC 403387 hydrochloride; NSC403387 hydrochloride; NSC-403387 HCl; NSC 403387 HCl; NSC403387 HCl; N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride; 1-(4-Methylquinazolin-2-yl)guanidine hydrochloride. Grades: ≥98% by HPLC. CAS No. 5361-15-9. Molecular formula: C10H11N5.HCl. Mole weight: 237.69. |  |
| ASIC Channel Modulator II, GMQ (2-guanidine-4-methylquinazoline, Acid-sensing Ion Channel Modulator II) | A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH (4.4% of pH 5-induced peak current with 1mM GMQ at pH 7.4), which is inhibitable by Amiloride. Intraplantar paw injection (10ul 100uM) is reported to elicit a pain response in asic3+/+, but not asic3-/-, mice in vivo. GMQ targeting area appears to overlap with Amiloride binding site in the pore region, but is distinct from ASIC calcium binding site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
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