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| Product | Description | |
|---|---|---|
| Go6976 | Go6976 is a Protein Kinase C ( PKC ) inhibitor, with an IC 50 of 20 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 136194-77-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10183. |  |
| GO? 6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, Go6976, PD 406976) | Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC50 = 7.9nM). In vitro, discriminates between Ca2+- dependent and -independent isoforms of PKC; selectively inhibits PKC alpha and PKC beta1 (IC50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Group: Biochemicals. Alternative Names: 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]py-rrolo[3,4-c]carbazole-12-propanenitrile; Go6976; PD 406976. Grades: Highly Purified. CAS No. 136194-77-9. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| GO-6976 | GO 6976, also known as PD-406976, is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. Gö 6976 blocked neurotrophin-induced signaling and autophosphorylation of neurotrophin-specific tyrosine kinase (Trk) receptors, either Trk B in cortical neurons or Trk A in GT1-1-trk9 cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GO6976; GO-6976; GO 6976; PD406976; PD 406976; PD-406976. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 136194-77-9. Molecular formula: C24H18N4O. Mole weight: 378.44. Purity: >98%. IUPACName: 3-(13-methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile. Canonical SMILES: N#CCCN(C1=C2C(CNC3=O)=C3C4=C1N(C)C5=C4C=CC=C5)C6=C2C=CC=C6. Product ID: ACM136194779. Alfa Chemistry ISO 9001:2015 Certified. |  |
| GO-6976 | Go6976 is a potent PKC inhibitor with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively). Synonyms: GO-6976; GO 6976; PD-406976; PD 406976; PD406976. Grades: >98%. CAS No. 136194-77-9. Molecular formula: C24H18N4O. Mole weight: 378.435. |  |
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