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Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 [1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GCA. CAS No. 1139889-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100540.
Golgicide A
Golgicide A. Group: Biochemicals. Grades: Purified. CAS No. 1139889-93-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Golgicide A
Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1. Golgicide A inhibited HSV-1 entry via beta-galactosidase reporter assay and impaired incoming virus transport to the nuclear periphery. Synonyms: GCA; (3aR,9bS)-rel-6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-. Grade: ≥98%. CAS No. 1139889-93-2. Molecular formula: C17H14F2N2. Mole weight: 284.30.
Golgicide A
Golgicide A is a Potent, selective and reversible inhibitor of GBF1 ArfGEF. Golgicide A inhibited HSV-1 entry via beta-galactosidase reporter assay and impaired incoming virus transport to the nuclear periphery. Inhibition of GBF1 via golgicide A can result in rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Golgicide A; GCA. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1139889-93-2. Molecular formula: C17H14F2N2. Mole weight: 284.31. Purity: >98%. IUPACName: (3aR,9bS)-6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline. Canonical SMILES: FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1. Product ID: ACM1139889932. Alfa Chemistry ISO 9001:2015 Certified.
Golgicide A-1
Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GCA-1. CAS No. 1394285-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100540C.
Golgicide A-2
Golgicide A-2, a Golgicide A (GCA) derivative, is the most active stereoisomer of golgicide A. Golgicide A-2 is a cis-Golgi ArfGEF GBF inhibitor with high selectivity and efficiency in killing An. stephensi larvae. It can be used for research on dengue virus-related diseases. Synonyms: GCA-2; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aS,4R,9bR)-; (3aS,4R,9bR)-golgicide A; (3aS,4R,9bR)-6,8-Difluoro-4-(3-pyridinyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline. Grade: ≥95%. CAS No. 1394285-50-7. Molecular formula: C17H14F2N2. Mole weight: 284.30.
(Rac)-Golgicide A
(Rac)-Golgicide A is a racemate of Golgicide A, which is a potent, highly specific and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1. Synonyms: (Rac)-GCA; 6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-. Grade: 95%. CAS No. 1005036-73-6. Molecular formula: C17H14F2N2. Mole weight: 284.30.
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