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GS-441524 is an analog nucleotide inhibitor against feline infectious peritonitis virus (FIPV). EC50 is 0.78?uM. GS-441524 is also a metabolite and intermediate of Remdesivir. Synonyms: 2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile; Remdesivir metabolite GS-441524; GS 441524; GS441524; (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile. Grade: 97%. CAS No. 1191237-69-0. Molecular formula: C12H13N5O4. Mole weight: 291.26.
GS-441524
GS-441524, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC 50 of 0.78 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1191237-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103586.
2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GS-441524. Appearance: Solid. CAS No. 1191237-69-0. Molecular formula: C12H13N5O4. Mole weight: 291.26. Purity: 0.98. IUPACName: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile. Canonical SMILES: C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N. Product ID: ACM1191237690. Alfa Chemistry ISO 9001:2015 Certified.
GS-443902
GS-443902 is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. Uses: Antiviral agents. Synonyms: GS-441524 triphosphate; Remdesivir metabolite; RDV-TP. Grade: 99.87%. CAS No. 1355149-45-9. Molecular formula: C12H16N5O13P3. Mole weight: 531.20.
GS-443902 trisodium
GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 ?M, 5 ?M for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium. CAS No. 1355050-21-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126303C.
GS-443902 trisodium
GS-443902 trisodium is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. Synonyms: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium. Grade: 99%. CAS No. 1355050-21-3. Molecular formula: C12H12N5Na4O13P3. Mole weight: 619.13.
GS-621763
GS-621763 is an orally bioavailable prodrug of GS-441524. The nucleoside metabolite of remdesivir, GS-441524 displays potent anti-SARS-CoV-2 efficacy, and is being evaluated in clinical as an oral antiviral therapeutic for COVID-19. Synonyms: GS-441524 prodrug. Grade: 98%. CAS No. 2647442-13-3. Molecular formula: C24H31N5O7. Mole weight: 501.53.
Obeldesivir
Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATV006. CAS No. 2647441-36-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145994.
Remdesivir
A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults. It has a role as an antiviral drug, a prodrug and an anticoronaviral agent. It is a carboxylic ester, a pyrrolotriazine, a nitrile, a phosphoramidate ester, a C-nucleoside and an aromatic amine. It is functionally related to a GS-441524. Alternative Names: 3QKI37EEHE. GS 5734. GS 5734 [WHO-DD]. GS-5734. CAS No. 1809249-37-3. Product ID: API1809249373. Molecular formula: C27H35N6O8P. Mole weight: 602.6. EINECS: 852-825-8. SMILES: CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4. Appearance: Off-white to yellow (Solid). Category: Antivirus APIs.
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