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| Product | Description | |
|---|---|---|
| GSK-3 inhibitor 1 | GSK-3 inhibitor 1 is a potent GSK-3 inhibitor. Grade: >98%. CAS No. 603272-51-1. Molecular formula: C22H17ClFN5O2. Mole weight: 437.85. |  |
| GSK-3 inhibitor 3 | GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3 , with IC 50 s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimers disease model, with IC 50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2227279-84-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-154851. |  |
| GSK-3 Inhibitor, AR-A014418, (N-[(4-Methoxyphenyl)methyl]-N-(5-nitro-2-thiazolyl)urea) | Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104nm). Inhibition is competitive with respect to ATP (Ki = 38nm). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 =um) and over 26 other kinases. Inhibits b-amyloid-mediated neurodegeneration in hippocampal slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. |  Worldwide |
| GSK-3 Inhibitor IX ((2Z,3E)-6-Bromoindirubin-3-oxime) | A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50=5nM). Its specificity has been tested against various Cdk's (IC50=83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50≥10uM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| GSK-3 Inhibitor IX - CAS 667463-62-9 | BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3?/? (IC?? = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells. Group: Fluorescence/luminescence spectroscopy. |  |
| GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 | The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3 Inhibitor X - CAS 740841-15-0 | The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3 Inhibitor XIII | An inhibitor of GSK-3. Synonyms: (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine. Grade: >98%. CAS No. 404828-14-4. Molecular formula: C18H15N5. Mole weight: 301.3. | |
| GSK-3 Inhibitor XIII - CAS 404828-08-6 | The GSK-3 Inhibitor XIII, also referenced under CAS 404828-08-6, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3 Inhibitor XV | The GSK-3 Inhibitor XV controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3 Inhibitor XVI - CAS 252917-06-9 | GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC?? = 10 and 6.7 nM against GSK-3? and GSK-3?, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| Bikinin, Arabidopsis GSK-3 Inhibitor (4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic Acid) | Cell-permeable. A highly specific inhibitor for the 7 Arabidopsis GSK-3 like kinase that activates brassinosteroid (BR) signaling downstream of the BR receptor. Bikinin directly binds the GSK3 BIN2 and acts as an ATP-competitive inhibitor. Furthermore, bikinin inhibits the activity of six other Arabidopsis GSK3s. Group: Biochemicals. Grades: Highly Purified. CAS No. 188011-69-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| (E/Z)-GSK-3β inhibitor 1 | (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-(2-Pyridinylmethylene)-indolin-2-one; 3-(2-Pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-. Grade: ≥98%. CAS No. 3367-88-2. Molecular formula: C14H10N2O. Mole weight: 222.24. | |
| GSK-3β inhibitor 1 | GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-[(Z)-(2-Pyridinyl)methylene]indoline-2-one; (3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(pyridin-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-. Grade: ≥95%. CAS No. 187325-53-7. Molecular formula: C14H10N2O. Mole weight: 222.24. | |
| GSK-3β inhibitor 11 | GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β ( GSK-3β ) inhibitor ( IC 50 =10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 536731-65-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148132. | |
| GSK-3β inhibitor 12 | GSK-3β inhibitor 12 is an inhibitor of GSK-3β, an enzyme playing an essential function in T cell differentiation and proliferation. Synonyms: GSK-3beta inhibitor 12; 2-(1H-Indol-3-yl)-N-(5-methylthiazol-2-yl)acetamide. CAS No. 784170-07-6. Molecular formula: C14H13N3OS. Mole weight: 271.34. | |
| GSK-3β inhibitor 2 | GSK-3β inhibitor 2 is a potent, selective and orally active GSK-3β inhibitor (IC50 = 1.1 nM) that can cross the blood-brain barrier and has the potential to treat Alzheimer's disease. Synonyms: 2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide; 2-{2-[(Cyclopropylcarbonyl)amino]-4-pyridinyl}-4-methoxy-1,3-thiazole-5-carboxamide; 5-Thiazolecarboxamide, 2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-. Grade: ≥98%. CAS No. 1702428-31-6. Molecular formula: C14H14N4O3S. Mole weight: 318.35. | |
| GSK-3β inhibitor 3 | GSK-3β inhibitor 3, a potent, selective, irreversible and covalent glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 6.6 μM), is used in the study of acute promyelocytic leukemia. Synonyms: 5-Acryloyl-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one; 5-Acryloyl-2-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one; 1,5-Benzothiazepin-4(5H)-one, 2-(4-fluorophenyl)-2,3-dihydro-5-(1-oxo-2-propen-1-yl)-; 5-Acryloyl-2,3-dihydro-2-(4-fluorophenyl)-1,5-benzothiazepin-4(5H)-one. Grade: ≥95%. CAS No. 1448990-73-5. Molecular formula: C18H14FNO2S. Mole weight: 327.37. | |
| GSK-3β inhibitor 3 | GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) , with an IC 50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448990-73-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141480. | |
| GSK-3 beta Inhibitor XXVII (3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl) | A cell-permeable pyridinyl pyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3b (Ki=4.9nM) with ~110-fold greater selectivity over Cdk2 (Ki=540nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3b-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50=76nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GSK-3? Inhibitor I - CAS 327036-89-5 | The GSK-3? Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor II - CAS 478482-75-6 | The GSK-3? Inhibitor II, also referenced under CAS 478482-75-6, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor VI - CAS 62673-69-2 | The GSK-3? Inhibitor VI, also referenced under CAS 62673-69-2, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor VIII - CAS 487021-52-3 | The GSK-3? Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor XI - CAS 626604-39-5 | The GSK-3? Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor XII, TWS119 - CAS 601514-19-6 | The GSK-3? Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor XVIII - CAS 1139875-74-3 | The GSK-3? Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor XXIV - CAS 1005201-24-0 | The GSK-3? Inhibitor XXIV, also referenced under CAS 1005201-24-0, controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor XXV | The GSK-3? Inhibitor XXV controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Inhibitor XXVII | The GSK-3? Inhibitor XXVII controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| GSK-3? Peptide Inhibitor, Cell-permeable | The GSK-3? Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution GSK-3 Inhibitor IX - CAS 667463-62-9 | The GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| InSolution GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9 | GSK-3 Inhibitor XVI, CHIR99021, CAS 252917-06-9, is a 25 mM solution in DMSO. A cell-permeable, ATP-competitive inhibitor of GSK-3 (IC?? = 10 & 6.7 nM for GSK-3? and GSK-3?, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| TWS119 (3-[[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol, GSK-3 Inhibitor) | A potent inhibitor of GSK-3 β (Glycogen synthase kinase-3 β) (IC50 = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation. Group: Biochemicals. Alternative Names: 3-[[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol. Grades: Highly Purified. CAS No. 601514-19-6. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| 10Z-Hymenialdisine | 10Z-Hymenialdisine is a pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα, respectively). 10Z-Hymenialdisine inhibits NF-κB activation and suppresses inflammatory gene expression. Synonyms: Hymenialdisine; (Z)-Hymenialdisine; 4-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one. Grade: ≥97% by HPLC. CAS No. 82005-12-7. Molecular formula: C11H10BrN5O2. Mole weight: 324.13. | |
| 1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride | 1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3) for the study of stem cell differentiation, tumors and neurodegenerative diseases. Synonyms: N-(7-Carbamimidamidoheptyl)guanidine dihydrochloride; N1,N7-Bisguanyl-1,7-diaminoheptane dihydrochloride; 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride. Grade: 95%. CAS No. 2193061-39-9. Molecular formula: C9H24Cl2N6. Mole weight: 287.23. | |
| 1-Azakenpaullone | 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β) , with an IC 50 value of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Akp. CAS No. 676596-65-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-59090. | |
| 1-Azakenpaullone - CAS 676596-65-9 | A Kenpaullone analog that acts as a potent and ATP-competitive inhibitor of GSK-3?. Group: Fluorescence/luminescence spectroscopy. | |
| 1-Benzyl-3-naphthalen-1-yl-urea | 1-Benzyl-3-naphthalen-1-yl-urea is an impurity of Tideglusib (T438700); a compound used in the treatment of brain atrophy and movement disorder issues. 1-Benzyl-3-naphthalen-1-yl-urea is also a potential glycogen synthase kinase 3 β (GSK-3) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 13256-79-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C18H16N2O, Molecular Weight: 276.33. US Biological Life Sciences. | Worldwide |
| 1-Benzyl-3-naphthalen-1-yl-urea-d7 | 1-Benzyl-3-naphthalen-1-yl-urea-d7 is the isotope labelled analog of 1-Benzyl-3-naphthalen-1-yl-urea (B285055); an impurity of Tideglusib (T438700) which is a compound used in the treatment of brain atrophy and movement disorder issues. 1-Benzyl-3-naphthalen-1-yl-urea is also a potential glycogen synthase kinase 3 β (GSK-3) inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg. Molecular Formula: C18H9D7N2O, Molecular Weight: 283.38. US Biological Life Sciences. | Worldwide |
| 2-(2-Cyclobuten-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | 2-(2-Cyclobuten-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 847158-88-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H17BO2. US Biological Life Sciences. | Worldwide |
| 2,2-Dichloro-3-(dimethylphenylsilyl)-cyclobutanone | 2,2-Dichloro-3-(dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 847158-94-5. Pack Sizes: 500mg, 1g. Molecular Formula: C12H14Cl2OSi. US Biological Life Sciences. | Worldwide |
| 2,3,5-Tri-O-benzyl-1,4-dideoxy-1,4-epithio-D-arabinitol | 2,3,5-Tri-O-benzyl-1,4-dideoxy-1,4-epithio-D-arabinitol, a promising therapeutic compound for diabetes mellitus, manifests an intricate mechanism of action. Acting as a reversible and competitive glycogen synthase kinase-3 (GSK-3) inhibitor, it regulates glucose metabolism robustly. In addition, the anti-proliferative impacts on cancer cells have rendered it a potential anti-cancer treatment candidate. Synonyms: (2R,3S,4S)-3,4-Bis(benzyloxy)-2-((benzyloxy)methyl)tetrahydrothiophene. CAS No. 187590-77-8. Molecular formula: C26H28O3S. Mole weight: 420.6. | |
| 2,3'-Dichloroacetophenone | 2,3'-Dichloroacetophenone is used as a reagent in the synthesis of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3 β (GSK-3 β). Also used as a reagent in the synthesis of benzimidazolyl pyridinones as insulin-like growth factor I (IGF-1R) kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 21886-56-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H6Cl2O. US Biological Life Sciences. | Worldwide |
| (2-Cyclobuten-1-yldimethylsilyl) benzene | (2-Cyclobuten-1-yldimethylsilyl) benzene is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 847158-86-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H16Si. US Biological Life Sciences. | Worldwide |
| (2-Cyclobuten-1-ylseleno)-benzene | (2-Cyclobuten-1-ylseleno)-benzene is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 847158-87-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C10H10Se. US Biological Life Sciences. | Worldwide |
| 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol | 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol. Group: Biochemicals. Alternative Names: GSK 3B Inhibitor XII; GSK-3 β Inhibitor XII; TWS 119. Grades: Highly Purified. CAS No. 601514-19-6. Pack Sizes: 5mg. Molecular Formula: C18H14N4O2, Molecular Weight: 318.33. US Biological Life Sciences. | Worldwide |
| 3-(Dimethylphenylsilyl)-cyclobutanone | 3-(Dimethylphenylsilyl)-cyclobutanone is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 847158-84-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H16OSi. US Biological Life Sciences. | Worldwide |
| 3-Methylthienyl-carbonyl-JNJ-7706621 | 3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective cyclin-dependent kinase (CDK) inhibitor, with IC50s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. It also has strong inhibitory effect on GSK-3 (IC50 = 0.041 μM) and modest potency against CDK4, VEGF-R2 and FGF-R2 with IC50s of 0.11, 0.13 and 0.22 μM, respectively. It can be used in cancer research. Synonyms: 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f; 4-({5-amino-1-[(3-methylthiophen-2-yl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide. CAS No. 443798-09-2. Molecular formula: C14H14N6O3S2. Mole weight: 378.43. | |
| 4- (2-Bromoacetyl) benzonitrile | 4- (2-Bromoacetyl) benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalo methyl ketones can be used in the study of novel GSK-3 inhibitors. Group: Biochemicals. Alternative Names: 2-Bromo-1-(4-cyanophenyl)ethanone; 2-Bromo-4'-cyanoacetophenone; 2-Bromo-p-cyanoacetophenone; 4- (2-Bromoacetyl) benzonitrile; 4- (2'-Bromoacetyl) benzonitrile; 4- (Bromoacetyl) benzonitrile; 4-Cyanophenacyl Bromide; NSC 157569; p-Cyano-α-bromoacetophenone; p-Cyano-ω-bromoacetophenone; p-Cyanophenacyl Bromide; α-Bromo-4-cyanoacetophenone. Grades: Highly Purified. CAS No. 20099-89-2. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4- (2-Bromoacetyl) benzonitrile-d4 | Useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalo methyl ketones can be used in the study of novel GSK-3 inhibitors. Group: Biochemicals. Alternative Names: 2-Bromo-1-(4-cyanophenyl)ethanone-d4; 2-Bromo-4'-cyanoacetophenone-d4; 2-Bromo-p-cyanoacetophenone-d4; 4- (2-Bromoacetyl) benzonitrile-d4; 4- (2'-Bromoacetyl) benzonitrile-d4; 4- (Bromoacetyl) benzonitrile-d4; 4-Cyanophenacyl-d4 bromide; NSC 157569-d4; p-Cyano-α-bromoacetophenone-d4; p-Cyano-ω-bromoacetophenone-d4; p-Cyanophenacyl-d4 Bromide; α-Bromo-4-cyanoacetophenone-d4. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 5-Bromoindole | 5-Bromoindole is a chemical intermediate that can be used for the synthesis of GSK-3 inhibitors and anti-cancer agents [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 10075-50-0. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g; 25 g. Product ID: HY-30236. | |
| 5-Bromoindole | A potential inhibitor of GSK-3. Group: Biochemicals. Alternative Names: 5-Bromo-. Grades: Highly Purified. CAS No. 10075-50-0. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 5-Chloro-2-oxindole | 5-Chloro-2-oxindole is used in the preparation of novel GSK-3 β inhibitors as anticancer agents. Group: Biochemicals. Alternative Names: 5-Chloro-1,3-dihydro-2H-indol-2-one; 5-Chloro-1,3-dihydroindol-2-one; 5-Chloro-2,3-dihydroindol-2-one; 5-Chloro-2-indolinone; 5-Chloro-2-oxindole; 5-Chloro-2-oxoindoline; 5-Chloroindol-2-one; 5-Chlorooxindole. Grades: Highly Purified. CAS No. 17630-75-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 5-Iodo-indirubin-3'-monoxime | 5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25 and CDK1/cyclin B that competes with ATP to bind to the catalytic site of the kinase with IC50s of 9, 20 and 25 nM, respectively. Synonyms: 2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-5-iodo-; 3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-5-iodo-1,3-dihydro-2H-indol-2-one. Grade: ≥95%. CAS No. 331467-03-9. Molecular formula: C16H10IN3O2. Mole weight: 403.17. | |
| 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione. | A GSK-3 inhibitor; use. Group: Biochemicals. Grades: Highly Purified. CAS No. 676596-64-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 9-ing-41 | 9-ING-41 is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3). 9-ING-41 induces cell cycle arrest, autophagy and apoptosis in bladder cancer cells. Synonyms: elraglusib. CAS No. 1034895-42-5. Molecular formula: C22H13FN2O5. Mole weight: 404.35. | |
| 9-ING-41 | 9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC 50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Elraglusib. CAS No. 1034895-42-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113914. | |
| A 1070722 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders. Uses: Potential treatment of neurodegenerative disorders. Synonyms: A 1070722; A1070722; A-1070722; 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea. Grade: ≥99% by HPLC. CAS No. 1384424-80-9. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. | |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Synonyms: ABC1183; ABC 1183; NSC797769; NSC-797769. Grade: > 99% by HPLC. CAS No. 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. | |
| Acetoacetamide | A building block that has been used in the preparation of glycogen synthase kinase 3 (GSK-3) inhibitors. Synonyms: 3-Oxobutanamide; 3-Oxobutyramide; Acetoacetic acid amide. Grade: > 95%. CAS No. 5977-14-0. Molecular formula: C4H7NO2. Mole weight: 101.11. | |
| ADW742 | NVP-ADW742 is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 μmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells. Synonyms: NVP-ADW742; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A. Grade: 0.98. CAS No. 475488-23-4. Molecular formula: C28H31N5O. Mole weight: 453.59. | |
| Aloisine A | Aloisine a is a cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Uses: A potent and selective cdk and gsk-3 inhibitor. Synonyms: Aloisine A; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol. Grade: ≥98%. CAS No. 496864-16-5. Molecular formula: C16H17N3O. Mole weight: 267.33. | |
| Aloisine B | Aloisine B is a potent and selective CDK and GSK-3 inhibitor with highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50=750.0 nM). Uses: A potent and selective cdk and gsk-3 inhibitor. Synonyms: 6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine; 6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 37; 6-(4-chlorophenyl)-7-isopropyl-5H-pyrrolo[2,3-b]pyrazine. Grade: ≥98%. CAS No. 496864-14-3. Molecular formula: C15H14ClN3. Mole weight: 271.75. | |
| Aloisine RP106 | A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk1/cyclin B, Cdk5/p35, and GSK-3 (IC50 = 700nM, 1.5 uM, and 920 nM, respectively). It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs. Synonyms: RP106; 7-n-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine. Grade: ≥98%. CAS No. 496864-15-4. Molecular formula: C17H19N3O. Mole weight: 281.4. | |
| Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 | A cell-permeable and reversible Alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3?. Group: Fluorescence/luminescence spectroscopy. | |
| Alsterpaullone - CAS 237430-03-4 | A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3? (IC?? = 4 nM) and Cdk1/cyclin B (IC?? = 35 nM). Group: Fluorescence/luminescence spectroscopy. | |
| amyloid P-IN-1 | Amyloid P-IN-1 is an orally available small molecule inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils for the depletion of serum amyloid-P (SAP) component from the circulation. Synonyms: GSK-3039294; GSK 3039294. Grade: 99%. CAS No. 1819986-22-5. Molecular formula: C30H44N2O14. Mole weight: 656.68. | |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Synonyms: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. Grade: ≥ 98%. CAS No. 487021-52-3. Molecular formula: C12H12N4O4S. Mole weight: 308.312. | |
| AR-AO 14418 | Glycogen Synthase Kinase 3 β (GSK-3 β) inhibitor. Group: Biochemicals. Alternative Names: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AR 0133418; GSK 3B Inhibitor VIII. Grades: Highly Purified. CAS No. 487021-52-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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