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| Product | Description | |
|---|---|---|
| GSK126 | GSK126 Inhibitor. Uses: Scientific use. Product Category: T2079. CAS No. 1346574-57-9. |  |
| GSK126 | GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Group: Biochemicals. Alternative Names: N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-Indole-4-carboxamide; N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide. Grades: Highly Purified. CAS No. 1346574-57-9. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| GSK126 | GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Synonyms: GSK2816126; GSK-2816126; GSK 2816126; GSK-126; GSK 126; (S)-1-(sec-Butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide. Grades: 98%. CAS No. 1346574-57-9. Molecular formula: C31H38N6O2. Mole weight: 526.69. |  |
| Cabotegravir (GSK744, GSK1265744) | Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2. Uses: Hiv integrase inhibitors. Synonyms: S/GSK1265744; S/GSK 1265744; S/GSK-1265744; GSK744; GSK-744; GSK 744; Cabotegravir. Grades: >98%. CAS No. 1051375-10-0. Molecular formula: C19H17F2N3O5. Mole weight: 405.35. | |
| GSK-1268992 | GSK-1268992 is one of a metabolite of Pazopanib which is a selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. Synonyms: GSK-1268992; GSK1268992; GSK 1268992; Pazopanib metabolite M24;5-((4-((3-(Hydroxymethyl)-2-methyl-indazol-6-yl)-methyl-amino)pyrimidin-2-yl)amino)-2-methyl-benzenesulfonamide. Grades: 98%. CAS No. 1414375-49-7. Molecular formula: C21H23N7O3S. Mole weight: 453.52. | |
| GSK-1268997 | GSK-1268997 is one of a metabolite of Pazopanib which is a selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. Synonyms: GSK-1268997; GSK1268997; GSK 1268997; Pazopanib metabolite M26; 5-((4-((2,3-Dimethylindazol-6-yl)-methyl-amino)pyrimidin-2-yl)amino)-2-(hydroxymethyl)benzenesulfonamide. Grades: 98%. CAS No. 1414375-50-0. Molecular formula: C21H23N7O3S. Mole weight: 453.52. | |
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