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| Product | Description | |
|---|---|---|
| Gue1654 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Gue1654 | Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα(I)-βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 397290-30-1. Pack Sizes: 1 mg. Product ID: HY-110114. |  |
| OXE-R-Gbg Coupling Modulator, Gue1654 (7- (Methylthio) -2- ( (2, 2-diphenylacetyl) amino) benzo[1, 2-d: 4, 3-d]bisthiazole, N-(7-(Methylsulfanyl)[1, 3]thiazolo[4, 5-g][1, 3]benzothiazol-2-yl)-2, 2-diphenylacetamide) | A membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-G-beta-gamma coupling upon receptor stimulation via direct OXE-R interaction, without affecting preexisting OXE-R-Galpha-beta interaction. Selectively inhibits OXE-R-G-beta-gamma coupling-mediated, but not OXE-R-G-alpha-mediated, downstream cellular signalings (Effective Conc. 1 to 30uM), displaying no inhibitory activity against cellular functions mediated by G-alpha or G-beta-gamma when coupled to other GPCRs. Comparing to Gallein, Gue1654 does not exert its activity via direct G-beta-gamma interaction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?OS?. US Biological Life Sciences. |  Worldwide |
| Gue 1654 | Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator selectively inhibiting Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue 1654 was shown to inhibit Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells. Synonyms: Gue1654; Gue 1654; Gue-1654. N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide. Grades: ≥97% by HPLC. CAS No. 397290-30-1. Molecular formula: C23H17N3OS3. Mole weight: 447.6. |  |
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