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| Product | Description | |
|---|---|---|
| GW 1100 | GW 1100 is a selective G protein-coupled receptor GPR40 antagonist. GW 1100 has been shown to reverse the effects GPR40 agonists which induce glucose-stimulated insulin secretion. Group: Biochemicals. Alternative Names: 4-[5-[ (2-Ethoxy-5-pyrimidinyl) methyl]-2-[[ (4-fluorophenyl) methyl]thio]-4-oxo-1 (4H) -pyrimidinyl]benzoic Acid Ethyl Ester; 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone) | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GW-1100 | A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Synonyms: GW 1100; GW-1100; GW1100. Grades: >98%. CAS No. 306974-70-9. Molecular formula: C27H25FN4O4S. Mole weight: 520.58. |  |
| GW405833 hydrochloride | GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB 1 antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242 hydrochloride. CAS No. 1202865-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110036A. |  |
| GW 7647 | GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPAR&delta. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPAR&alpha. GW 7647 exhibits lipid-lowering and anti-inflammatory effects. Synonyms: GW-7647; GW 7647; GW7647. 2-[[4-[2-[[ (Cyclohexylamino) carbonyl] (4-cyclohexylbutyl) amino]ethyl]phenyl]thio]-2-methylpropanoic acid. Grades: ≥99% by HPLC. CAS No. 265129-71-3. Molecular formula: C29H46N2O3S. Mole weight: 502.75. | |
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